The Application and Molecular Mechanisms of Mitochondria-Targeted Antioxidants in Chemotherapy-Induced Cardiac Injury DOI Creative Commons

Chih-Jen Liu,

Lu‐Kai Wang, Fu‐Ming Tsai

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 176 - 176

Published: March 7, 2025

Chemotherapeutic agents play a crucial role in cancer treatment. However, their use is often associated with significant adverse effects, particularly cardiotoxicity. Drugs such as anthracyclines (e.g., doxorubicin) and platinum-based cisplatin) cause mitochondrial damage, which one of the main mechanisms underlying These drugs induce oxidative stress, leading to an increase reactive oxygen species (ROS), turn damage mitochondria cardiomyocytes, resulting impaired cardiac function heart failure. Mitochondria-targeted antioxidants (MTAs) have emerged promising cardioprotective strategy, offering potential solution. efficiently scavenge ROS within mitochondria, protecting cardiomyocytes from damage. Recent studies shown that MTAs, elamipretide, SkQ1, CoQ10, melatonin, significantly mitigate chemotherapy-induced not only reduce but also help maintain structure function, stabilize membrane potential, prevent excessive opening permeability transition pore, thus preventing apoptosis dysfunction. In this review, we integrate recent findings elucidate cardiotoxicity highlight substantial therapeutic MTAs reducing are expected offer safer more effective treatment options for patients clinical practice.

Language: Английский

The Application and Molecular Mechanisms of Mitochondria-Targeted Antioxidants in Chemotherapy-Induced Cardiac Injury DOI Creative Commons

Chih-Jen Liu,

Lu‐Kai Wang, Fu‐Ming Tsai

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 176 - 176

Published: March 7, 2025

Chemotherapeutic agents play a crucial role in cancer treatment. However, their use is often associated with significant adverse effects, particularly cardiotoxicity. Drugs such as anthracyclines (e.g., doxorubicin) and platinum-based cisplatin) cause mitochondrial damage, which one of the main mechanisms underlying These drugs induce oxidative stress, leading to an increase reactive oxygen species (ROS), turn damage mitochondria cardiomyocytes, resulting impaired cardiac function heart failure. Mitochondria-targeted antioxidants (MTAs) have emerged promising cardioprotective strategy, offering potential solution. efficiently scavenge ROS within mitochondria, protecting cardiomyocytes from damage. Recent studies shown that MTAs, elamipretide, SkQ1, CoQ10, melatonin, significantly mitigate chemotherapy-induced not only reduce but also help maintain structure function, stabilize membrane potential, prevent excessive opening permeability transition pore, thus preventing apoptosis dysfunction. In this review, we integrate recent findings elucidate cardiotoxicity highlight substantial therapeutic MTAs reducing are expected offer safer more effective treatment options for patients clinical practice.

Language: Английский

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