Molecular Engineering of NIR-II Excitable Phototheranostic for Mitochondria-Targeted Cancer Photoimmunotherapy DOI
Qiang Kang, Fen Liu, Senyou Tan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The advancement of mitochondria-targeted near-infrared-II (NIR-II) excitable phototheranostics constitutes a promising strategy for improving fluorescence-image-guided cancer phototherapy. However, developing phototheranostic agents that simultaneously combine high-contrast NIR-II fluorescence imaging with effective multimodal therapeutic techniques remains substantial challenge. Herein, we reported shielding-donor-acceptor-donor-shielding structured (FCD-T) by molecular engineering strategy, followed self-assembly glutathione-responsive copolymer to form FCD-T nanoparticles. introduction functional bithiophene endows significant electron-donating properties and reduces intermolecular π-π stacking interactions. robust π-conjugation fluorene good rigidity would enhance the intramolecular charge transfer capability. Therefore, NPs exhibited an absorption peak at 1075 nm emission 1280 nm. Upon light excitation, such nanoparticles could generate excellent photothermal photodynamic performances biocompatibility. Moreover, phototherapy further facilitated mitochondrial apoptosis-related pathways, activating antitumor immunity inhibiting tumor growth single irradiation low doses.

Language: Английский

Molecular Engineering of NIR-II Excitable Phototheranostic for Mitochondria-Targeted Cancer Photoimmunotherapy DOI
Qiang Kang, Fen Liu, Senyou Tan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The advancement of mitochondria-targeted near-infrared-II (NIR-II) excitable phototheranostics constitutes a promising strategy for improving fluorescence-image-guided cancer phototherapy. However, developing phototheranostic agents that simultaneously combine high-contrast NIR-II fluorescence imaging with effective multimodal therapeutic techniques remains substantial challenge. Herein, we reported shielding-donor-acceptor-donor-shielding structured (FCD-T) by molecular engineering strategy, followed self-assembly glutathione-responsive copolymer to form FCD-T nanoparticles. introduction functional bithiophene endows significant electron-donating properties and reduces intermolecular π-π stacking interactions. robust π-conjugation fluorene good rigidity would enhance the intramolecular charge transfer capability. Therefore, NPs exhibited an absorption peak at 1075 nm emission 1280 nm. Upon light excitation, such nanoparticles could generate excellent photothermal photodynamic performances biocompatibility. Moreover, phototherapy further facilitated mitochondrial apoptosis-related pathways, activating antitumor immunity inhibiting tumor growth single irradiation low doses.

Language: Английский

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