Trends and Characteristics during 17 Years of Naloxone Distribution and Administration through a Harm Reduction Program in Pittsburgh, Pennsylvania DOI Creative Commons
Nabarun Dasgupta,

Alice Bell,

Malcolm Visnich

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

ABSTRACT Objective Describe time trends during 17.6 years of community-based naloxone distribution. Methods Analysis administrative records from a harm reduction program in Pittsburgh, Pennsylvania, USA, collected encounters for overdose education, dispensing and refills. Monthly were analyzed using segmented regression. Programmatic context aided interpretation quantitative findings. We also evaluated impacts 2014 state legislation loosening prescribing requirements providing Good Samaritan protections. Results From July 2005 to January 2023 there 16,904 service by 7,582 unique participants, resulting 70,234 doses dispensed, with 5,521 response events (OREs), utilizing 8,756 doses. After legislation, new participants increased 10.4 65.9 per month. New tended be older (46 vs. 37 years), female (58% 35%), White race, more likely family/friends as opposed people who use drugs themselves. Consequently, ORE participant fell 1.46 0.47 the year after enactment. On average, 1.63 (95% CI: 1.60, 1.65) administered ORE, which did not change substantially over 17 ( χ 2 =0.28, 3 df, p =0.60) evolution prescription opioids, heroin, illicitly manufactured fentanyl. In 98.0% OREs person experienced “was okay”, i.e., survived. Emergency medical services called 16% overall, but <7% since 2019. There 106 emesis 1,000 4mg nasal spray compared intramuscular injection; 48 reports anger. Titration was associated lower rates adverse events. Conclusions While created environment expansion, reaching previously underserved communities required intentional programmatic development outreach. Long-term consistency <2 high survival rate, robust utilization all lend confidence prioritizing distribution directly their social networks.

Language: Английский

Pre-Exposure Prophylaxis Awareness and Demand Creation: Overlooked Populations and Opportunities to Move Forward DOI
Katryna McCoy, Joanne E. Mantell, Robert Deiss

et al.

JAIDS Journal of Acquired Immune Deficiency Syndromes, Journal Year: 2025, Volume and Issue: 98(5S), P. e170 - e180

Published: March 31, 2025

Background: Pre-exposure prophylaxis (PrEP) for HIV prevention has been available since 2012, but uptake remains disappointing and inequitable. Furthermore, there is little evidence on the effectiveness of interventions to increase PrEP demand among priority populations in United States. The objectives this article were describe how consumer perceptions vary by distinct population groups identify gaps awareness, knowledge, interest. Methods: We synthesized evidence-based improve heavily burdened HIV. focus centered factors, people's awareness PrEP, especially people who are likely benefit, influences uptake. Results: Awareness equity use vulnerable States remain low because both demand-side obstacles accessibility challenges. Designing an effective package involves integrating strategies that address interest/motivation, access. Conclusions: underutilization 1.2 million individuals could benefit from it highlights need creation reduce disparities. To effectively benefits requires consideration characteristics target structural inequalities contribute PrEP-related Demand activities can correct misconceptions, provide help decide whether a good fit them. utilization implementation science frameworks essential generation supply-side barriers use.

Language: Английский

Citations

0
Safe Injection Self-Efficacy is associated with HCV and HIV seropositivity among people who inject drugs in the San Diego-Tijuana border region DOI Creative Commons
Katie Bailey, Daniela Abramovitz, Gudelia Rangel

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Safe injection self-efficacy (SISE) is negatively associated with risk behaviors among people who inject drugs (PWID) but has not been examined in differing environments. We compared responses to a validated SISE scale between PWID San Diego, California and Tijuana, Mexico, examine correlates of Tijuana.

Language: Английский

Citations

1
Safe Injection Self-Efficacy is Associated with HCV and HIV Seropositivity Among People Who Inject Drugs in the San Diego–Tijuana Border Region DOI
Katie Bailey, Daniela Abramovitz, Gudelia Rangel

et al.

AIDS and Behavior, Journal Year: 2024, Volume and Issue: 28(11), P. 3629 - 3642

Published: July 26, 2024

Language: Английский

Citations

1
Trends and Characteristics during 17 Years of Naloxone Distribution and Administration through a Harm Reduction Program in Pittsburgh, Pennsylvania DOI Creative Commons
Nabarun Dasgupta,

Alice Bell,

Malcolm Visnich

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

ABSTRACT Objective Describe time trends during 17.6 years of community-based naloxone distribution. Methods Analysis administrative records from a harm reduction program in Pittsburgh, Pennsylvania, USA, collected encounters for overdose education, dispensing and refills. Monthly were analyzed using segmented regression. Programmatic context aided interpretation quantitative findings. We also evaluated impacts 2014 state legislation loosening prescribing requirements providing Good Samaritan protections. Results From July 2005 to January 2023 there 16,904 service by 7,582 unique participants, resulting 70,234 doses dispensed, with 5,521 response events (OREs), utilizing 8,756 doses. After legislation, new participants increased 10.4 65.9 per month. New tended be older (46 vs. 37 years), female (58% 35%), White race, more likely family/friends as opposed people who use drugs themselves. Consequently, ORE participant fell 1.46 0.47 the year after enactment. On average, 1.63 (95% CI: 1.60, 1.65) administered ORE, which did not change substantially over 17 ( χ 2 =0.28, 3 df, p =0.60) evolution prescription opioids, heroin, illicitly manufactured fentanyl. In 98.0% OREs person experienced “was okay”, i.e., survived. Emergency medical services called 16% overall, but <7% since 2019. There 106 emesis 1,000 4mg nasal spray compared intramuscular injection; 48 reports anger. Titration was associated lower rates adverse events. Conclusions While created environment expansion, reaching previously underserved communities required intentional programmatic development outreach. Long-term consistency <2 high survival rate, robust utilization all lend confidence prioritizing distribution directly their social networks.

Language: Английский

Citations

0