Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Dec. 8, 2022

Abstract Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various activities, including clearance aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target development cancer medications recent years. However, because tumor show avoidance apoptosis, which causes treatment resistance recurrence, numerous studies been devoted alternative mortality processes, namely necroptosis, pyroptosis, ferroptosis, cuproptosis; these modalities extensively studied shown be crucial therapy effectiveness. Furthermore, evidence suggests that undergoing may alter immunogenicity microenvironment (TME) some extent, rendering it more suitable inhibiting progression metastasis. In addition, other components TME undergo abovementioned forms induce immune attacks on cells, resulting enhanced antitumor responses. Hence, this review discusses molecular processes features cuproptosis effects novel proliferation Importantly, introduces complex affect biology. It also summarizes potential agents nanoparticles or inhibit their therapeutic based from vivo vitro reports clinical trials inducers evaluated treatments patients. Lastly, we summarized impact modulating drug advantages adding modulators over conventional treatments.

Language: Английский

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Cuproptosis: mechanisms and links with cancers

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: March 7, 2023

Abstract Cuproptosis was a copper-dependent and unique kind of cell death that separate from existing other forms death. The last decade has witnessed considerable increase in investigations programmed death, whether copper induced an independent form long been argued until mechanism cuproptosis revealed. After that, increasing number researchers attempted to identify the relationship between process cancer. Thus, this review, we systematically detailed systemic cellular metabolic processes copper-related tumor signaling pathways. Moreover, not only focus on discovery its mechanism, but also outline association cancers. Finally, further highlight possible therapeutic direction employing ion ionophores with cuproptosis-inducing functions combination small molecule drugs for targeted therapy treat specific

Language: Английский

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MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154991 - 154991

Published: Nov. 30, 2023

Language: Английский

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lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

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Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 15, 2025

Language: Английский

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The Role of Copper Ions in Mediating the Anti‐Cancer Effects Using Nanomaterials

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Copper plays a pivotal role in human physiology, particularly oncology, acting both as facilitator of progression and also potential avenue for advanced therapeutic approaches. Maintaining copper homeostasis is crucial. The dysregulation implicated tumor growth through its involvement critical processes angiogenesis, proliferation, metastasis. elevation level the microenvironment (TME) activates oncogenic pathways to drive neovascularization sustained malignancies. However, same reliance on offers unique weakness that can be leveraged innovative interventions. recent advances nanomedicine enable synthesis nanostructures help modulate with precision offering multifaceted approaches copper‐based cancer therapy controlled release mechanism, optimized structures induce cuproptosis, selective eradication cells minimum systemic toxicity. This review explores dual biology, emphasizing contribution tumors emerging application targeted therapy. highlights harnessing therapies their transformative from bench bed side novel, highly effective, clinical safety.

Language: Английский

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Identification of cuproptosis-related miRNAs in triple-negative breast cancer and analysis of the miRNA–mRNA regulatory network

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28242 - e28242

Published: March 27, 2024

The close association between cuproptosis and tumor immunity in triple-negative breast cancer (TNBC) allows its monitoring for predicting the prognosis of patients with TNBC. Nevertheless, biological function prognostic value cuproptosis-related miRNAs their target genes have not been reported.

Language: Английский

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Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1083 - 1083

Published: June 22, 2024

Regulated cell death, a regulatory form of demise, has been extensively studied in multicellular organisms. It plays pivotal role maintaining organismal homeostasis under normal and pathological conditions. Although alterations various regulated death modes are hallmark features tumorigenesis, they can have divergent effects on cancer cells. Consequently, there is growing interest targeting these mechanisms using small-molecule compounds for therapeutic purposes, with substantial progress observed across human cancers. This review focuses summarizing key signaling pathways associated apoptotic autophagy-dependent death. Additionally, it explores crucial related to other the context cancer. The discussion delves into current understanding processes their implications treatment, aiming illuminate novel strategies combat therapy resistance enhance overall therapy.

Language: Английский

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Identification of cuproptosis-related lncRNAs with the significance in prognosis and immunotherapy of oral squamous cell carcinoma

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 171, P. 108198 - 108198

Published: Feb. 21, 2024

Language: Английский

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Heterogeneity of cancer-associated fibroblast subpopulations in prostate cancer: Implications for prognosis and immunotherapy

Translational Oncology, Journal Year: 2024, Volume and Issue: 52, P. 102255 - 102255

Published: Dec. 24, 2024

Language: Английский

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