COVID-19 infection may reduce serum testosterone levels and increase the risk of erectile dysfunction: A two-sample Mendelian randomization study
Ting Wang,
No information about this author
Chao Li,
No information about this author
Jinbo Song
No information about this author
et al.
Investigative and Clinical Urology,
Journal Year:
2025,
Volume and Issue:
66(2), P. 152 - 152
Published: Jan. 1, 2025
Coronavirus
disease
2019
(COVID-19)
infection
may
affect
serum
hormones
levels
and
male
sexual
function.
This
study
aims
to
provide
evidence
for
the
causal
relationship
between
COVID-19
infection,
testosterone
risk
of
erectile
dysfunction
(ED)
using
a
two-sample
Mendelian
randomization
(MR)
approach.
Summary-level
data
(199,569
samples
12,321,875
single
nucleotide
polymorphisms
[SNPs])
were
obtained
from
Rebecca's
study,
while
ED
(6,175
cases
217,630
controls)
sourced
Bovijn's
study.
Genetic
variations
linked
used
as
instrumental
variables
(IVs)
in
meta-analyses
genome-wide
association
studies
(GWASs)
involving
6,406
902,088
controls
Host
Genetics
Initiative.
The
inverse-variance
weighted
(IVW)
method
was
primarily
employed
evaluate
potential
associations
levels,
ED.
mode,
weighted-median
simple-median
sensitivity.
Heterogeneity
pleiotropic
outlier
assessed
Cochran's
Q
test
MR-Egger
regression.
MR
analysis
demonstrated
that
associated
with
reduced
(odds
ratio
[OR]
0.966,
95%
confidence
interval
[CI]
0.938-0.993,
p=0.016)
an
increased
(OR
1.205,
CI
1.063-1.367,
p=0.004)
when
IVW
methods.
Sensitivity
analyses
utilizing
various
IV
sets
approach
remained
consistent.
is
decrease
Male
patients
recovering
need
pay
special
attention
their
sex
hormone
health.
Language: Английский
Infertility: A common target of antivaccine misinformation campaigns
Vaccine,
Journal Year:
2024,
Volume and Issue:
42(4), P. 924 - 929
Published: Jan. 21, 2024
Misinformation,
disinformation,
and
conspiracy
theories
about
vaccines
are
key
drivers
of
vaccine
hesitancy.
A
repeated
false
claim
COVID-19
is
that
the
cause
female
infertility.
Dating
back
decades,
various
have
linked
vaccination
programs
with
infertility
thus
harmed
in
Africa,
Asia,
Central
America,
particularly
against
polio
tetanus.
In
United
States,
Europe,
Australia,
human
papilloma
virus
(HPV)
been
falsely
blamed
for
primary
ovarian
insufficiency
(POI).
After
distribution
began
December
2020,
almost
immediately
there
arose
claiming
these
menstrual
irregularities,
miscarriages,
infertility,
promoted
by
noted
antivaccine
activists
Robert
F.
Kennedy,
Jr.
Andrew
Wakefield
among
others.
Here
we
will
explore
history
this
narrative,
how
it
has
promulgated
past
repurposed
to
vaccines,
strategies
counter
it.
Language: Английский
Evaluating male sexual function and reproductive health during Omicron outbreak in China
Jiatong Xiao,
No information about this author
Bolong Liu,
No information about this author
Juliet Matsika
No information about this author
et al.
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(11), P. e0310145 - e0310145
Published: Nov. 7, 2024
There
are
currently
no
studies
exploring
omicron
infection
and
male
sexual
function
semen
quality.
Our
aim
was
to
estimate
changes
in
quality
men
recovering
from
since
the
COVID-19
Omicron
pandemic
started
China
late
2022.
We
collected
1540
questionnaires
assessed
before
acute
phase
after
by
using
International
Index
of
Erectile
Function-5,
Premature
Ejaculation
Diagnostic
Tool,
Arizona
Sexual
Experience
Scale.
also
analysis
results
247
patients.
During
infection,
proportion
erectile
dysfunction
significantly
higher
than
but
ejaculatory
not
altered;
In
addition,
showed
significant
difference
concentration,
activity
PR
a+b
sperm
forward
movement
compared
pre-infection.:
can
affect
as
well
experience
patients
phase.
Decreased
due
may
be
related
body
temperature
anxiety
during
infection.
Language: Английский
The impact of COVID-19 vaccination on the sexual health of male healthcare professionals
The Journal of Infection in Developing Countries,
Journal Year:
2023,
Volume and Issue:
17(12), P. 1700 - 1705
Published: Dec. 31, 2023
Introduction:
The
coronavirus
disease
2019
(COVID-19)
pandemic
negatively
affected
the
mental
and
sexual
health
of
individuals,
especially
healthcare
professionals.
In
this
study,
we
aimed
to
investigate
changes
in
anxiety
activity
male
professionals
following
vaccination.
Methodology:
This
prospective
cross-sectional
descriptive
online
survey
was
conducted
between
July
1,
2021
November
2021,
involving
a
total
170
Socio-demographic
characteristics,
pre-
post-vaccination
levels
participants
were
compared.
Results:
There
significant
increase
only
intercourse
times
post
vaccination
(p
=
0.034).
Beck
inventory
score
decreased
from
median:
19
(minimum
(min):
16,
maximum
(max):
47)
before
17,
(min:
10,
max:
43)
after
<
0.001).
Likewise,
Arizona
Sexual
Experiences
Scale
(ASEX)
scores
(median:
min:
5,
20)
compared
12,
18)
International
Index
Erectile
Function
(IIEF)
also
increased
(25.49
±
6.50)
(24.71
7.10)
Orgasmic
function,
desire,
satisfaction
overall
improved
0.013,
p
0.001,
0.027,
Conclusions:
Mental
disorders
with
COVID-19
pandemic.
addition
immunity,
vaccine
had
positive
effects
on
activity.
Language: Английский
Updates in the pathophysiology of COVID-19 infection in male reproductive and sexual health: a literature review
Meshari A. Alzahrani,
No information about this author
Khalid Alkhani,
No information about this author
Abdullah M. Alassaf
No information about this author
et al.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
14
Published: Feb. 26, 2024
This
extensive
comprehensive
review
explores
the
impact
of
Coronavirus
disease
2019
(COVID-19)
pandemic
on
men’s
sexual
and
reproductive
health.
We
conducted
a
literature
focusing
possible
pathophysiology
by
which
severe
acute
respiratory
syndrome
corona
virus
2
(SARS-CoV-2)
affects
systems.
reviewed
most
studies
that
reported
SARS-CoV-2
infection
Testicular,
Epididymal,
Prostatic,
Penile
tissue.
Also,
we
focused
evaluating
semen
parameters
male
hormones.
Finally,
COVID-19
vaccine’s
effect
Findings
revealed
adverse
consequences
at
cellular
organ
levels
genital
tract.
However,
data
are
still
controversial.
The
initial
regarding
vaccination
was
promising
promoted
safety
for
conclude
this
paper
offering
recommendations
to
address
these
potentially
improve
health
among
men
in
post-COVID-19
era.
Language: Английский
Novel Insight into the Cellular and Molecular Signaling Pathways of Costus speciosus in the Treatment of COVID-19: A Review
Nature Cell and Science,
Journal Year:
2024,
Volume and Issue:
2(1), P. 42 - 58
Published: March 30, 2024
Costus
speciosus
(C.speciosus)
Koen.ex
Retz.
is
a
perennial
herb
with
tuberous
horizontal
rhizome
and
spirally
arranged
simple
leaves
bisexual
flowers.
5It
exhibits
multiple
cytotypes,
occurs
worldwide,
6
grows
wild
in
shady
places
of
mixed
deciduous
forests
India.
7Rhizomes
Language: Английский
Development of a Risk Predictive Model for Erectile Dysfunction at 12 Months after COVID-19 Recovery: A Prospective Observational Study
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(19), P. 5757 - 5757
Published: Sept. 27, 2024
Objectives:
To
develop
a
risk
prediction
model
for
the
identification
of
features
involved
in
erectile
dysfunction
(ED)
at
12
months
following
COVID-19
recovery.
Methods:
We
performed
an
observational
prospective
multicentre
study.
Participants
were
classified
according
to
their
history
COVID-19:
(I)
patients
with
past
and
(II)
without
previous
microbiological
diagnosis
COVID-19.
A
total
361
(past
COVID-19,
n
=
166;
no
195)
assessed
from
January
2022
March
2023.
Patients
The
primary
outcome
measure
was
ED,
through
5-item
International
Index
Erectile
Function
(IIEF-5).
Data
concerning
epidemiologic
variables,
comorbidities
active
treatment
also
collected.
binary
logistic
regression
predictive
model.
Among
models
developed,
we
selected
one
higher
Area
Under
Curve
(AUC).
Results:
median
age
55
years
both
groups.
ED
prevalence
55.9%
44.1%
those
best
developed
comprised
40
variables
had
AUC
0.8.
Conclusions:
after
application
our
tool
community
setting
could
eventually
prevent
adverse
effects
on
cardiovascular
health
associated
unfavourable
economic
impact.
Language: Английский
Regional burden of vaccine-associated menstrual disorders and sexual dysfunction: a retrospective study
Jinyoung Jeong,
No information about this author
Hyesu Jo,
No information about this author
Jaeyu Park
No information about this author
et al.
Life Cycle,
Journal Year:
2024,
Volume and Issue:
4
Published: Dec. 28, 2024
Language: Английский
Evaluating male sexual function and reproductive health during Omicron outbreak in China: A cross-sectional study
Jinbo Chen,
No information about this author
Jiatong Xiao,
No information about this author
Bolong Liu
No information about this author
et al.
Authorea (Authorea),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 27, 2023
Our
aim
was
to
estimate
changes
in
sexual
function
and
semen
quality
men
recovering
from
infection
since
the
Omicron
pandemic
started
China
late
2022.
We
collected
1540
questionnaires
assessed
male
before
acute
phase
after
by
using
International
Index
of
Erectile
Function-5,
Premature
Ejaculation
Diagnostic
Tool,
Arizona
Sexual
Experience
Scale.
also
analysis
results
247
patients.
During
infection,
proportion
erectile
dysfunction
significantly
higher
than
but
ejaculatory
not
altered;
In
addition,
showed
significant
difference
concentration,
activity
PR
a+b
sperm
forward
movement
compared
pre-infection.
can
affect
as
well
experience
patients
phase.
The
risk
factors
for
decreased
due
included
body
temperature
anxiety
during
infection.
Language: Английский
Evaluating male sexual function and reproductive health during Omicron outbreak in China
Jiatong Xiao,
No information about this author
Bolong Liu,
No information about this author
Juliet Matsika
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 18, 2023
Abstract
Background
There
are
currently
no
studies
exploring
omicron
infection
and
male
sexual
function
semen
quality.
Our
aim
was
to
estimate
changes
in
quality
men
recovering
from
since
the
Omicron
pandemic
started
China
late
2022.
Methods
We
collected
1540
questionnaires
assessed
before
acute
phase
after
by
using
International
Index
of
Erectile
Function-5,
Premature
Ejaculation
Diagnostic
Tool,
Arizona
Sexual
Experience
Scale.
also
analysis
results
247
patients.
Results
During
infection,
proportion
erectile
dysfunction
significantly
higher
than
but
ejaculatory
not
altered;
In
addition,
showed
significant
difference
concentration,
activity
PR
a
+
b
sperm
forward
movement
compared
pre-infection.
Conclusions
can
affect
as
well
experience
patients
phase.
The
risk
factors
for
decreased
due
included
body
temperature
anxiety
during
infection.
Trial
registration:
study
registered
with
ClinicalTrials.gov
approved
Ethics
Committee
Xiangya
Medical
College.
Language: Английский