Etiology of Male Infertility: an Update

Reproductive Sciences, Journal Year: 2023, Volume and Issue: 31(4), P. 942 - 965

Published: Nov. 30, 2023

Language: Английский

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Elderberry diet improves sperm quality and histological parameters of testicular tissue in adult male rats exposed to methamphetamine

Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102732 - 102732

Published: Jan. 13, 2025

Language: Английский

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Promethazine induces testicular and epididymal toxicity via the upregulation of xanthine oxidase/uric acid-mediated oxidative stress signaling

Comparative Clinical Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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Histopathological evaluation of infertility: Lessons from laboratory rodents.

PubMed, Journal Year: 2024, Volume and Issue: 39(6), P. 671 - 690

Published: June 1, 2024

Infertility is a growing challenge globally with emerging risk factors. There are effective laboratory tests to evaluate infertility in humans, nevertheless, some measures, especially histopathological evaluations, invasive due the pain inflicted when accessing reproductive organs and obtaining samples; hence, their relevance may be limited humans. However, these evaluations provide essential information on etiopathogenesis of likely mechanisms action potential therapeutic candidates. Also, non-invasive methods available, such as assay testosterone blood semen analysis, both which predictors testicular functions. This review provides detailed available investigations infertility, qualitative quantitative assessments gonadal tissues, specific cell counts, sperm morphology characterization, focus procedures, interpretation, pathophysiological basis. Data from literature revealed that examinations organs, well spermatozoa, useful understanding pathogenesis incident infertility. Histopathological evaluation range basic hematoxylin eosin stains special stains. findings (such spermatogenic cells planimetric variables, like seminiferous tubule diameter theca corpus luteum thickness) quantified analyzed for comparison. Some skill required investigations, limiting factor; however, they important tools translational medicine.

Language: Английский

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Ureaplasma urealyticum upregulates seminal fluid leukocytes and lowers human semen quality: a systematic review and meta-analysis

Basic and Clinical Andrology, Journal Year: 2025, Volume and Issue: 35(1)

Published: April 17, 2025

Abstract Background Ureaplasma urealyticum belongs to the class Mollicutes and causes non-gonococcal urethritis, an inflammation of urethra that is linked with impaired semen quality. However, some reports are contradictory, reported effect U. on specific sperm variables not consistent. Thus, this study synthesized findings from published primary data provides a robust reliable inference impact associated mechanisms Methods A systematic search was conducted until 31st May, 2024, Cochrane, Google Scholar, Pubmed. The Population, Exposure, Comparator/Comparison, Outcomes, Study Design (PECOS) model adopted. populations were male in their reproductive ages who infected confirmed positive versus control age-matched non-infected or treated, while outcomes included conventional parameters, seminal fluid leucocyte count, interleukin-6 (IL-6) concentrations, studies either cross-sectional longitudinal. Results When compared control, quantitative analysis demonstrated significantly reduced ejaculate volume (SMD 0.33 [95% CI: 0.15, 0.52] p = 0.0004), concentration 0.47 0.31, 0.64] < 0.00001), total motility 0.73 0.43, 1.02] motile count 0.21 0.17, 0.26] normal morphology 0.88 0.42, 1.35] 0.0002), but increased leukocyte -0.82 -1.61, -0.02] 0.04). In addition, qualitative revealed urealyticum- subjects had higher levels IL-1β, IL-6, IL-8, TNF-α, peroxidase, leukocytes , neutrophils, CD4 + T cells, CD8 cells when control. Furthermore, DNA fragmentation apoptotic observed Conclusions These lowers quality via upregulation leukocytes, elastase, pro-inflammatory cytokines, fragmentation. further required elucidate underlying association between decline develop effective therapies for condition.

Language: Английский

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Engineered nanoparticles potentials in male reproduction

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Abstract Background The escalating prevalence of fertility problems in the aging population necessitates a comprehensive exploration contributing factors, extending beyond environmental concerns, work‐related stress, and unhealthy lifestyles. Among these, rising incidence testicular disorders emerges as pivotal determinant issues. Current treatment challenges are underscored by limitations high‐dose frequent drug administration, coupled with substantial side effects irreversible trauma inflicted surgical interventions on tissue. Material methods formidable barrier posed blood–testis compounds complexities treating diseases, presenting significant therapeutic obstacle. advent nanocarriers, their distinctive attributes, holds promise overcoming this impediment. These nanocarriers exhibit exceptional biocompatibility, membrane penetration capabilities, can strategically target through surface ligand modification, thereby augmenting bioavailability enhancing efficacy. Results discussion This review concentrates transformative potential delivery agents to By summarizing key applications, we illuminate strides made utilizing novel avenue effectively treat diseases. Conclusions Nanocarriers critical delivering

Language: Английский

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Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Seminal oxidative stress has been shown to be a key factor in the development of male infertility. However, benefits infertility treatments with antioxidants such as coenzyme Q10 (CoQ10) remains controversial. The aim present study was assess effects CoQ10 supplementation on semen quality, i.e., volume, total sperm number, concentration, motility, percentage progressive motility and morphology. In addition, circulating testosterone, luteinizing hormone (LH), follicle-stimulating (FSH), inhibin B levels were evaluated. A systematic review meta-analysis randomized controlled trials (RCTs) performed quality serum reproductive hormones. We conducted strategic literature search Cochrane, EMBASE, PubMed/MEDLINE, Scopus, Web Science databases collected only RCTs. data RCTs then meta-analyzed according PRISMA guidelines. Out 2,144 studies, eight classified eligible. studies included 877 subjects; 462 CoQ10-treated 415 untreated/placebo-treated. found significantly higher counts (SMD -13.38 [95% CI: -16.33, -10.43] P< 0.0001), -7.26 -10.15, -4.36] 0.00001) -6.386 -10.04, -2.73] P= 0.0006), normally formed -1.96 -3.29, -0.62] 0.004) subjects compared untreated/placebo-treated subjects. Nonetheless, there significant inter-study heterogeneity these studies. Moreover, testosterone -0.59 -0.79, -0.40] -0.92 -1.47, -0.37] 0.001) recorded lowered LH 1.77 1.26, 2.28] FSH concentrations 1.60 1.38, 1.81] 0.00001). Interestingly, no hormonal had effect volume 0.12 -0.13, 0.37] 0.34) concentration -6.69 -16.28, 2.90] 0.17). Our shows that increases count, proportion association levels. therefore supports view beneficial use treatment. further well-designed sufficiently large numbers are required reach final conclusion.

Language: Английский

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Vitamin D3 Supplementation Improve Sexual Behaviors of Male Wistar Rats Treated with Flunitrazepam

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100028 - 100028

Published: Jan. 1, 2025

Language: Английский

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Synthetic Cathinones Induce Developmental Arrest, Reduce Reproductive Capacity, and Shorten Lifespan in the C. elegans Model

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 33 - 33

Published: Feb. 18, 2025

Drug abuse presents a significant global health challenge as the illicit drug market progresses from classic drugs to growing prevalence of New Psychoactive Substances (NPS), particularly synthetic cathinones, which, although illegal, are often falsely marketed safe and legal alternatives. The rapid increase in use these complicates assessment their safety effects on human health. However, they pose unique toxicological concerns that remain largely uncharacterized. This study investigated toxic three namely, methylone, pentedrone, 4-methylethcathinone (4-MEC), using model organism C. elegans. We assessed impact substances animal survival, development, reproductive behavior, longevity. Our results showed short-term exposure (24 h) concentrations 5.0 mM or higher significantly reduced survival rates, while prolonged (72 led more pronounced toxicity, reducing rates at low 1.0 mM. Moreover, sublethal resulted developmental arrest. Additionally, pentedrone impaired capacity, 4-MEC shortened elegans lifespan. These findings highlight urgent need for further investigation into implications cathinone through vivo models continues rise.

Language: Английский

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Cytotoxicity of methamphetamine exposure on Sertoli cells: a pilot study with implications for male infertility

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 4, 2025

Methamphetamine (Meth), a psychoactive drug, has been shown to reduce testicular weight and decrease sperm count, indicating its potential role in contributing male infertility. We therefore assessed Meth's effects (0.1–100 μM) on TM4 Sertoli cell viability, toxicity, proliferation (trypan blue exclusion assay), mitochondrial activity (MA) (XTT while transepithelial electrical resistance (TEER) was used examine monolayer permeability. The acute study (only 24-hour Meth exposure) mimics recreational users the chronic study, addicts who require daily doses (24–96 hours). Acute treatment had minimal impact viability exposure resulted reduced increased toxicity dose-related manner. suppressed division at 72 hours, both 96 hours. Long-term suppression of MA observed for (20 µM 100 µM). Both affected permeability across blood–testis barrier (BTB), which persisted up Given pivotal cells spermatogenesis, our findings provide two-pronged mechanism Meth-induced infertility indicate that short-term may have long-term germinal epithelium.

Language: Английский

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