Melatonin Interplay in Physiology and Disease—The Fountain of Eternal Youth Revisited DOI Creative Commons
Cándido Ortiz-Placín, Ginés M. Salido, Antonio González

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 682 - 682

Published: May 8, 2025

Melatonin (N-acetyl-5-methoxytryptamine) is a hormone associated with the regulation of biological rhythms. The indoleamine secreted by pineal gland during night, following circadian rhythm. highest plasmatic levels are reached whereas lowest achieved day. In addition to gland, other organs and tissues also produce melatonin, like, for example, retina, Harderian glands, gut, ovaries, testes, skin, leukocytes, or bone marrow. list extensive, including cerebellum, airway epithelium, liver, kidney, adrenals, thymus, thyroid, pancreas, carotid body, placenta, endometrium. At all these locations, availability melatonin intended local use. Interestingly, decline amplitude secretion occurs in old subjects comparison that found younger subjects. Moreover, genetic environmental factors primary causes diseases, oxidative stress key contributor most pathologies. Numerous studies exist show interesting effects different models disease. Impairment its might have deleterious consequences cellular physiology. this regard, natural compound carrier not yet completely known potential deserves consideration. Thus, has emerged as helpful ally could be considered guard powerful tools orchestrate homeostasis majorly based on antioxidant effects. review, we provide an overview widespread actions against diseases preferentially affecting elderly.

Language: Английский

Ovarian Endometrioma Disrupts Oocyte‐Cumulus Communication and Mitochondrial Function, With Melatonin Mitigating the Effects DOI Creative Commons
Lei Ge, Yali Yang,

Yuqing Gao

et al.

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

ABSTRACT Ovarian endometrioma (OEM), a particularly severe form of endometriosis, is an oestrogen‐dependent condition often associated with pain and infertility. The mechanisms by which OEM impairs fertility, through its direct impact on oocyte‐cumulus cell (CC) communication related pathways, remain poorly understood. This study investigates the oocyte‐CC explores melatonin's therapeutic potential. We used mouse model employed ovarian transcriptome gene set enrichment analyses to identify disrupted alongside phalloidin staining for cytoskeletal analysis, gap junction coupling analysis intercellular communication, mitochondrial function assessments cellular metabolism. Our results showed that significantly steroidogenesis cumulus function, leading increased apoptosis, transzonal projections (TZPs), impaired antioxidant transfer oocytes. culminates in oxidative stress, dysfunction, compromised ATP production. oocytes also exhibited abnormalities, including DNA damage, maturation defects, spindle assembly disruptions, aneuploidy. identifies TZPs as key pathological feature highlights potential restore mitigate improve reproductive outcomes.

Language: Английский

Citations

1
Melatonin Interplay in Physiology and Disease—The Fountain of Eternal Youth Revisited DOI Creative Commons
Cándido Ortiz-Placín, Ginés M. Salido, Antonio González

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 682 - 682

Published: May 8, 2025

Melatonin (N-acetyl-5-methoxytryptamine) is a hormone associated with the regulation of biological rhythms. The indoleamine secreted by pineal gland during night, following circadian rhythm. highest plasmatic levels are reached whereas lowest achieved day. In addition to gland, other organs and tissues also produce melatonin, like, for example, retina, Harderian glands, gut, ovaries, testes, skin, leukocytes, or bone marrow. list extensive, including cerebellum, airway epithelium, liver, kidney, adrenals, thymus, thyroid, pancreas, carotid body, placenta, endometrium. At all these locations, availability melatonin intended local use. Interestingly, decline amplitude secretion occurs in old subjects comparison that found younger subjects. Moreover, genetic environmental factors primary causes diseases, oxidative stress key contributor most pathologies. Numerous studies exist show interesting effects different models disease. Impairment its might have deleterious consequences cellular physiology. this regard, natural compound carrier not yet completely known potential deserves consideration. Thus, has emerged as helpful ally could be considered guard powerful tools orchestrate homeostasis majorly based on antioxidant effects. review, we provide an overview widespread actions against diseases preferentially affecting elderly.

Language: Английский

Citations

0