Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 29, 2023
Abstract
Background:
Evidence
synthesis
is
used
by
decision-makers
in
various
ways,
such
as
developing
evidence-based
recommendations
for
clinical
guidelines.
Clinical
guideline
development
groups
(GDGs)
typically
discuss
evidence
findings
a
multidisciplinary
group,
including
patients,
healthcare
providers,
policymakers,
etc.
A
recent
mixed
methods
systematic
review
(MMSR)
identified
no
gold
standard
format
optimally
presenting
to
these
groups.
However,
it
provided
94
help
produce
more
effective
summary
formats
general
syntheses
(e.g.,
reviews).
To
refine
the
MMSR
create
actionable
guidance
producers,
we
aimed
explore
with
participants
involved
and
development.
Methods:
We
conducted
descriptive
qualitative
study
using
online
focus
group
workshops
February
March
2023.
These
participatory
co-design
approach
interactive
voting
activities
identify
preferences
format's
essential
content
style.
created
topic
guide
focused
on
from
support,
≥3
supporting
studies,
those
prioritised
an
expert
advisory
via
pragmatic
prioritisation
exercise
MoSCoW
method
(Must,
Should,
Could,
Will
not
haves).
Eligible
must
be/have
been
GDGs
and/or
synthesis.
Groups
were
recorded
transcribed.
Two
independent
researchers
analysed
transcripts
directed
analysis
pre-defined
codes
MMSR.
Results:
Thirty
individuals
participated
six
coded
79
of
codes.
Participants
suggested
“less
more”
structured
that
minimises
methodological
steps
statistical
data,
promoting
accessibility
all
audiences
judicious
use
links
further
information
full
report.
They
emphasised
concise,
consistently-presented
which
highlight
key
messages,
flag
readers
indicators
trust
producers
(i.e.,
logos,
websites,
conflict
interest
statements),
certainty
(without
extenuating
details).
Conclusions:
This
based
developers
about
summaries
support
decision-making.
Next
involve
user-testing
prototype
through
one-on-one
semi-structured
interviews
optimise
BMC Public Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 23, 2024
Abstract
Background
Monkeypox
(Mpox)
virus
infection
is
a
topic
of
growing
interest
today
because
its
potential
public
health
impact
and
concern
about
possible
outbreaks.
Reliable
up-to-date
sources
information
that
provide
accurate
data
on
transmission,
symptoms,
prevention,
treatment
are
essential
for
understanding
effectively
addressing
this
disease.
Therefore,
the
aim
present
study
to
determine
prevalence
Mpox
infection.
Methods
An
exhaustive
systematic
review
meta-analysis
was
carried
out
using
available
in
PubMed,
Scopus,
Web
Science,
Embase,
ScienceDirect
databases
up
August
3,
2023.
The
were
analyzed
R
software
version
4.2.3.
quality
cross-sectional
studies
formed
part
assessed
Joanna
Briggs
Institute
Meta-Analysis
Statistics
Assessment
Review
Instrument
(JBI-MAStARI)
tool.
In
addition,
subgroup
analysis
performed
based
populations.
Results
Through
electronic
searches
five
databases,
total
1833
identified.
Twenty-four
articles
included,
with
sample
35,959
participants
from
34
countries.
pooled
each
included
was:
social
networks
reached
59%
(95%
CI:
50–68%;
29,146
participants;
22
studies;
I
2
=
100%;
p
<
0.01);
Internet
61%
44–77%;
14,002
5
0.01),
radio
10%
07–13%;
8917
4
93%;
television
accounted
24%
09–43%;
14,896
8
combination
45%
31–60%;
4207
7
99%;
newspapers,
it
15%
05–27%;
2841
6
friends
relatives
19%
12–28%;
28,470
19
World
Health
Organization
(WHO)
17%
07–29%;
1656
3
97%;
Centers
Disease
Control
Prevention
(CDC)
03–21%;
2378
98%;
WHO
CDC
websites
60%
48–72%;
1828
96%;
finally,
scientific
journals
16–33%;
16,775
13
0.01).
Conclusion
suggests
people
access
variety
gain
knowledge
infection,
strong
emphasis
online
such
as
Internet.
However,
important
note
accuracy
these
can
vary,
underscoring
need
promote
reliable
disease
ensure
health.
Salud Ciencia y Tecnología,
Journal Year:
2025,
Volume and Issue:
5, P. 1467 - 1467
Published: Feb. 22, 2025
Introduction:
The
article
addresses
the
issue
of
state
policy
aimed
at
comprehensive
psychological
support
and
rehabilitation
population
in
context
sustainable
development.
Methods:
research
was
conducted
based
on
empirical
experience
effective
management
decisions
Ukraine
over
past
three
years
Russian-Ukrainian
war,
using
a
approach
involving
analysis,
synthesis,
descriptive,
(survey
method),
structural
methods.Results:
study
measured
stress
levels
different
age
categories
before
after
group
training
sessions
(duration
–
2
months)
to
assess
effectiveness
for
internally
displaced
persons
PSM-25
Lemyr-Tessier-Fillion
measurement
methodology.
Resilience
Centre
(Ivano-Frankivsk)
as
shelter
during
2023-2024
covered
120
people
from
various
groups
persons.
results
obtained
method
indicate
significant
all
groups.
As
statistics
show,
high
level
respondents
decreased
by
7%,
low
6%.
Conclusions:
Thus,
31%
reported
high-stress
completing
sessions,
lowest
figure
compared
percentage
with
medium
low-stress
levels.
highest
indicator,
37%,
observed
adolescent
(15-22
years),
which
is
quite
logical,
this
age,
there
reduced
capacity
self-regulation
emotional
background.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Abstract
Large
language
models
(LLMs)
are
used
to
seek
health
information.
We
investigate
the
prompt-dependent
compliance
of
LLMs
with
evidence-based
communication
guidelines
and
evaluate
efficacy
a
minimal
behavioral
intervention
for
boosting
laypeople’s
prompting.
Study
1
systematically
varied
prompt
informedness,
topic,
LLM
compliance.
2
randomized
300
UK
participants
interact
under
standard
or
boosted
prompting
conditions.
Independent
blinded
raters
assessed
response
instruments.
found
that
failed
standards,
even
informed
The
quality
responses
was
be
contingent
upon
informedness.
revealed
laypeople
frequently
generated
poor-quality
responses;
however,
simple
boost
improved
quality,
though
it
remained
below
optimal
standards.
These
findings
underscore
inadequacy
as
standalone
tool.
It
is
imperative
enhance
interfaces,
integrate
them
frameworks,
teach
engineering.
Study
Registration:
German
Clinical
Trials
Register
(DRKS)
(Reg.
No.:
DRKS00035228)
Ethical
Approval:
Ethics
Committee
University
Potsdam
(Approval
No.
52/2024)
Egyptian Journal of Medical Human Genetics,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: April 3, 2025
Abstract
Background
Puerperal
fever
is
a
major
cause
of
maternal
morbidity,
traditionally
associated
with
bacterial
infections.
However,
the
role
viral
pathogens
and
genetic
factors
remains
inadequately
studied,
particularly
in
low-
middle-income
countries
(LMICs).
Objective
This
study
aimed
to
investigate
prevalence
infections,
pathogens,
variants
postpartum
women
diagnosed
puerperal
at
Edo
State
University
Teaching
Hospital,
Auchi,
Nigeria.
Methods
A
cross-sectional
involving
300
(200
100
controls)
was
conducted
from
April
2021
May
2022.
Blood
samples
were
analyzed
for
antibodies
DNA/RNA
using
Bio-Rad
ELISA
kits
polymerase
chain
reaction
(PCR).
PCR–RFLP
real-time
PCR
TaqMan
probes
used
genotyping.
Bacterial
identified
through
culture
techniques.
Genetic
polymorphisms
immune-regulatory
genes
(IL-6,
TNF-α,
TLR4,
HLA
Class
I
II)
PCR-based
methods.
Statistical
analysis
employed
SPSS
version
25,
Chi-square
tests,
multivariate
logistic
regression,
corrections
multiple
comparisons.
Results
The
group
showed
significantly
higher
rates
Cytomegalovirus
(CMV)
(40%
vs.
10%,
p
<
0.001),
Herpes
Simplex
Virus
(HSV-1:
35%
15%,
=
0.002;
HSV-2:
28%
14%,
0.01),
Epstein-Barr
(EBV)
(30%
12%,
0.005).
confirmed
presence
group:
CMV
(30%),
HSV-1
(25%),
HSV-2
(20%),
EBV
(22%),
compared
controls
(5%,
8%,
6%,
4%,
respectively).
infections
more
prevalent
group,
Streptococcus
pyogenes
(32%
0.001)
Escherichia
coli
(25%
0.002)
being
notable
contributors.
Additionally,
IL-6
(rs1800795)
TNF-α
(rs1800629)
an
increased
risk
(
0.05).
controlled
confounding
variables
such
as
socioeconomic
health
status.
Conclusion
highlights
dual
well
factors,
fever.
findings
underscore
need
integrated
diagnostic
approaches,
including
screening
testing,
enhance
outcomes
LMICs.
Health Research Policy and Systems,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Dec. 6, 2023
An
estimated
85%
of
research
resources
are
wasted
worldwide,
while
there
is
growing
demand
for
context-based
evidence-informed
health
policymaking.
In
low-
and
middle-income
countries
(LMICs),
uptake
policymaking
practice
even
lower,
little
known
about
the
barriers
to
translation
evidence
policy
local
implementation.
We
aimed
compile
current
on
in
LMICs
using
scoping
review.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(7), P. e28871 - e28871
Published: March 29, 2024
The
dissemination
and
implementation
of
evidence
in
health
contexts
have
been
a
concern
several
international
organizations
responsible
for
recommending
actions
to
policymakers.
World
Health
Organization
has
advocating
an
ecosystem
improve
clinical
practice
professional
education.
Thus,
this
article,
we
address
the
challenges
developing
from
point
view
education,
considering
teaching,
focused
on
knowledge
translation.
There
are
three
pivotal
challenges:
producing
qualified
knowledge;
adequate
communication
synthesized
evidence;
institutional
policy
sustain
implemented
continuous
updated
flow.
helps
understand
these
flows
between
production
knowledge,
based
capacity
resources
different
systems.
It
needs
be
developed
field
feedback
contribute
third-generation
being
used
by
users
services.
BMJ Nutrition Prevention & Health,
Journal Year:
2024,
Volume and Issue:
7(2), P. 415 - 425
Published: Aug. 29, 2024
This
article
continues
from
a
prior
commentary
on
evaluating
the
risk
of
bias
in
randomised
controlled
trials
addressing
nutritional
interventions.
Having
provided
synopsis
issues,
we
now
address
how
to
understand
trial
results,
including
interpretation
best
estimates
effect
and
corresponding
precision
(eg,
95%
CIs),
as
well
applicability
evidence
patients
based
their
unique
circumstances
patients'
values
preferences
when
trading
off
potential
desirable
undesirable
health
outcomes
indicators
cholesterol),
burden
cost
an
intervention).
Authors
can
express
for
relative
terms
(relative
risks,
reductions,
OR
or
HRs)-measures
that
are
generally
consistent
across
populations-and
absolute
(risk
differences)-measures
more
intuitive
clinicians
patients.
CIs,
range
which
true
plausibly
lies,
capture
estimates.
To
apply
results
patients,
should
consider
extent
study
participants
were
similar
interventions
evaluated
applicable
if
all
patient-important
benefit
harm
reported.
Subsequently,
with
respect
balance
benefits,
harms
burdens
(and
possibly
costs)
making
decisions
about
dietary
Systematic Reviews,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: March 27, 2024
Abstract
Background
Evidence
synthesis
is
used
by
decision-makers
in
various
ways,
such
as
developing
evidence-based
recommendations
for
clinical
guidelines.
Clinical
guideline
development
groups
(GDGs)
typically
discuss
evidence
findings
a
multidisciplinary
group,
including
patients,
healthcare
providers,
policymakers,
etc.
A
recent
mixed
methods
systematic
review
(MMSR)
identified
no
gold
standard
format
optimally
presenting
to
these
groups.
However,
it
provided
94
help
produce
more
effective
summary
formats
general
syntheses
(e.g.,
reviews).
To
refine
the
MMSR
create
actionable
guidance
producers,
we
aimed
explore
with
participants
involved
and
development.
Methods
We
conducted
descriptive
qualitative
study
using
online
focus
group
workshops
February
March
2023.
These
participatory
co-design
approach
interactive
voting
activities
identify
preferences
format's
essential
content
style.
created
topic
guide
focused
on
from
support,
≥
3
supporting
studies,
those
prioritized
an
expert
advisory
via
pragmatic
prioritization
exercise
MoSCoW
method
(Must,
Should,
Could,
Will
not
haves).
Eligible
must
be/have
been
GDGs
and/or
synthesis.
Groups
were
recorded
transcribed.
Two
independent
researchers
analyzed
transcripts
directed
analysis
pre-defined
codes
MMSR.
Results
Thirty
individuals
participated
six
coded
79
of
codes.
Participants
suggested
“less
more”
structured
that
minimizes
methodological
steps
statistical
data,
promoting
accessibility
all
audiences
judicious
use
links
further
information
full
report.
They
emphasized
concise,
consistently
presented
highlight
key
messages,
flag
readers
indicators
trust
producers
(i.e.,
logos,
websites,
conflict
interest
statements),
certainty
(without
extenuating
details).
Conclusions
This
based
developers
about
summaries
support
decision-making.
The
next
involve
user-testing
prototype
through
one-on-one
semi-structured
interviews
optimize
CADERNOS IBERO-AMERICANOS DE DIREITO SANITÁRIO,
Journal Year:
2024,
Volume and Issue:
13(3), P. 12 - 25
Published: Sept. 30, 2024
Objective:
The
main
objective
of
this
study
is
to
report
on
the
implementation
and
results
“Supporting
Health-Related
Judicial
Decisions
in
Brazil”
project
conducted
at
Health
Technology
Assessment
Center,
Hospital
Sírio-Libanês
through
“Programa
de
Apoio
ao
Desenvolvimento
Institucional
do
Sistema
Único
Saúde”,
Brazil.
Methods:
This
an
experience
a
Sírio-Libanês.
Results:
activities
occurred
2023
included
two
online
training
courses
primary
studies
systematic
reviews,
11
one-day
workshops
with
technical-scientific
content
for
members
Technical
Support
Centers
Judiciary
(NATJus),
40
consultations
magistrates
digital
platform,
reports
addressing
most
legally
claimed
technologies
Brazil;
methodological
tools,
national
forum
(hybrid
event),
10
chat-based
mentorships
NATJus
members;
maintenance
open-access
blog,
by
publishing
news
relevant
topics
law
health.
Discussion
conclusion:
has
contributed
improvement
judicial
decision-making
process
providing
range
aimed
aiding
prioritization
health
that
are
clearly
effective
safe
over
those
ineffective,
harmful,
or
have
uncertain
effects.
Submission:
04/09/24|
Review:
06/29/24|
Approval:
08/18/24
