Copper bioavailability, uptake, toxicity and tolerance in plants: A comprehensive review

Chemosphere, Journal Year: 2020, Volume and Issue: 262, P. 127810 - 127810

Published: Aug. 1, 2020

Language: Английский

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Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper

Environmental Management, Journal Year: 2019, Volume and Issue: 65(1), P. 131 - 159

Published: Dec. 12, 2019

Abstract Decades of study indicate that copper oral exposures are typically not a human health concern. Ingesting high levels soluble salts can cause acute gastrointestinal symptoms and, in uncommon cases, liver toxicity susceptible individuals with repeated exposure. This focused toxicological review evaluated the current literature since last comprehensive reviews (2007–2010). Our identified limitations existing United States and international guidance for determining an reference dose (RfD) essential metals like copper. Instead, alternative method using categorical regression analysis to develop optimal considers deficiency, toxicity, integrates information from animal studies was reviewed interpreting RfD We also considered subchronic or chronic genetic susceptibility dysregulation leading rare occurrences other organ elevated Based on this approach, 0.04 mg Cu/kg/day would be protective adults children. is possible exposure allows background dietary exposures. intended patients disorders sensitivity within typical nutritional intake ranges, nor it those excessive supplement intake. Less mineral forms soil have reduced bioavailability as compared more water diet, which should risk assessments

Language: Английский

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Antimicrobial Nano-Agents: The Copper Age

ACS Nano, Journal Year: 2021, Volume and Issue: 15(4), P. 6008 - 6029

Published: April 1, 2021

The constant advent of major health threats such as antibacterial resistance or highly communicable viruses, together with a declining antimicrobial discovery, urgently requires the exploration innovative therapeutic approaches. Nowadays, strategies based on metal nanoparticle technology have demonstrated interesting outcomes due to their intrinsic features. In this scenario, there is an emerging and growing interest in copper-based nanoparticles (CuNPs). Indeed, pure metallic form, oxides, combination sulfur, CuNPs peculiar behaviors that result effective activity associated stimulation essential body functions. Here, we present critical review state art regarding vitro vivo evaluations absorption, distribution, metabolism, excretion, toxicity (ADMET) assessments. Considering potentiality treatments, within Review encounter need summarize provide expected perspectives contributions infectious disease management.

Language: Английский

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Copper Dyshomeostasis in Neurodegenerative Diseases—Therapeutic Implications

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(23), P. 9259 - 9259

Published: Dec. 4, 2020

Copper is one of the most abundant basic transition metals in human body. It takes part oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining integrity blood vessels, as well iron homeostasis, antioxidant defense, neurotransmitter synthesis. may also be involved cell signaling participate modulation membrane receptor-ligand interactions, control kinase related phosphatase functions, many cellular pathways. Its role important controlling gene expression nucleus. In nervous system particular, copper myelination, by modulating synaptic activity excitotoxic death cascades induced neurotrophic factors, for various neuronal functions. Current data suggest that both excess levels deficiency can harmful, careful homeostatic important. This knowledge opens up an new area potential therapeutic interventions based on supplementation or removal neurodegenerative diseases including Wilson’s disease (WD), Menkes (MD), Alzheimer’s (AD), Parkinson’s (PD), others. However, much remains to discovered, how regulate homeostasis prevent neurodegeneration, when chelate copper, supplement it.

Language: Английский

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AIE-based luminescence probes for metal ion detection

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 429, P. 213693 - 213693

Published: Dec. 17, 2020

Language: Английский

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The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy

Cancers, Journal Year: 2020, Volume and Issue: 12(12), P. 3594 - 3594

Published: Dec. 1, 2020

In the human body, copper (Cu) is a major and essential player in large number of cellular mechanisms signaling pathways. The involvement Cu oxidation-reduction reactions requires close regulation metabolism order to avoid toxic effects. many types cancer, variations protein levels have been demonstrated. These result increased concentrations intratumoral alterations systemic distribution copper. Such homeostasis may promote tumor growth or invasiveness even confer resistance treatments. Once characterized, dysregulated pinpointing several promising biomarkers for clinical use with prognostic predictive capabilities. altered cancer cells different responses are strongly supporting development treatments disrupt, deplete, increase tumors. metallic nature as chemical element key anticancer agents via synthesis nanoparticles copper-based complexes antineoplastic properties therapy. Finally, some these new therapeutic strategies such chelators ionophores shown results preclinical setting, others already clinic.

Language: Английский

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Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 20, 2023

Abstract Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying initiation, propagation, and ultimate execution of cuproptosis in tumors remain unknown. Here, we show that content significantly elevated gastric (GC), especially malignant tumors. Screening reveals METTL16, an atypical methyltransferase, critical mediator through m 6 A modification on FDX1 mRNA. Furthermore, stress promotes METTL16 lactylation at site K229 followed cuproptosis. The process inhibited SIRT2. Elevated improves therapeutic efficacy ionophore– elesclomol. Combining elesclomol with AGK2, SIRT2-specific inhibitor, induce vitro vivo. These results reveal significance non-histone protein Given lactate concentrations GC, induction becomes promising strategy for GC.

Language: Английский

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Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria

SAGE Open Medicine, Journal Year: 2021, Volume and Issue: 9

Published: Jan. 1, 2021

The COVID-19 is a pandemic caused by SARS-CoV-2 which has infected over 74 million people, killing more than 1,600,000 people around the world as of 17th December 2020. Accumulation free radicals coupled weakened antioxidant system leads to oxidative stress, will further worsen respiratory diseases, inclusive. This study aimed examine levels some antioxidants and stress markers in patients.

Language: Английский

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Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review

Frontiers in Surgery, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 5, 2022

Copper has been used as an antimicrobial agent long time ago. Nowadays, copper-containing nanoparticles (NPs) with properties have widely in all aspects of our daily life. Copper-containing NPs may also be incorporated or coated on the surface dental materials to inhibit oral pathogenic microorganisms. This review aims detail NPs’ mechanism, cytotoxic effect and their application dentistry.

Language: Английский

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The Role of Copper Homeostasis in Brain Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 13850 - 13850

Published: Nov. 10, 2022

In the human body, copper is an important trace element and a cofactor for several enzymes involved in energy production, iron metabolism, neuropeptide activation, connective tissue synthesis, neurotransmitter synthesis. Copper also necessary cellular processes, such as regulation of intracellular signal transduction, catecholamine balance, myelination neurons, efficient synaptic transmission central nervous system. naturally present some foods available dietary supplement. Only small amounts are typically stored body large amount excreted through bile urine. Given critical role breadth local concentrations distribution transporter proteins brain to maintain steady state internal environment. The dysfunction metabolism or regulatory pathways results imbalance homeostasis brain, which can lead myriad acute chronic pathological effects on neurological function. It suggests unique mechanism linking neuronal activation within This article explores relationship between impaired neuropathophysiological progress diseases.

Language: Английский

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