International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 945 - 964
Published: Jan. 1, 2024
Abstract:
The
active
metabolite
of
irinotecan
(CPT-11),
7-ethyl-10-hydroxycamptothecin
(SN38),
is
100–
1000
times
more
than
CPT-11
and
has
shown
inhibitory
effects
on
a
range
cancer
cells,
including
those
from
the
rectal,
small
cell
lung,
breast,
esophageal,
uterine,
ovarian
malignancies.
Despite
SN38's
potent
anticancer
properties,
its
hydrophobicity
pH
instability
have
caused
substantial
side
activity
loss,
which
make
it
difficult
to
use
in
clinical
settings.
To
solve
above
problems,
construction
SN38-based
drug
delivery
systems
one
most
feasible
methods
improve
solubility,
enhance
stability,
increase
targeting
ability,
bioavailability,
therapeutic
efficacy
reduce
adverse
reactions.
Therefore,
based
mechanism
systems,
this
paper
reviews
SN38
polymeric
micelles,
liposomal
nanoparticles,
protein
conjugated
targeted
by
aptamers
ligands,
antibody-drug
couplings,
magnetic
targeting,
photosensitive
redox-sensitive
multi-stimulus-responsive
co-loaded
systems.
focus
review
nanocarrier-based
We
hope
provide
reference
for
translation
application
novel
medications.
Keywords:
SN38,
system,
Cancer Cell,
Journal Year:
2022,
Volume and Issue:
40(9), P. 1044 - 1059.e8
Published: Sept. 1, 2022
Cisplatin-based
chemotherapy
remains
the
primary
treatment
for
unresectable
and
metastatic
muscle-invasive
bladder
cancers
(MIBCs).
However,
tumors
frequently
develop
chemoresistance.
Here,
we
established
a
orthotopic
MIBC
mouse
model
with
gene-edited
organoids
to
recapitulate
full
course
of
in
patients.
We
found
that
partial
squamous
differentiation,
called
semi-squamatization,
is
associated
acquired
chemoresistance
both
mice
human
MIBCs.
Multi-omics
analyses
showed
cathepsin
H
(CTSH)
correlated
semi-squamatization.
Cathepsin
inhibition
by
E64
induces
differentiation
pyroptosis,
thus
specifically
restrains
chemoresistant
Mechanistically,
activates
tumor
necrosis
factor
pathway,
which
required
terminal
pyroptosis
cells.
Our
study
revealed
semi-squamatization
type
lineage
plasticity
chemoresistance,
suggesting
via
targeting
CTSH
potential
therapeutic
strategy
Nano Letters,
Journal Year:
2023,
Volume and Issue:
23(5), P. 1989 - 1999
Published: Feb. 24, 2023
Cancer
stem-like
cells
(CSCs)
play
key
roles
in
chemoresistance,
tumor
metastasis,
and
clinical
relapse.
However,
current
CSC
inhibitors
lack
specificity,
efficacy,
applicability
to
different
cancers.
Herein,
we
introduce
a
nanomaterial-based
approach
photothermally
induce
the
differentiation
of
CSCs,
termed
"photothermal
differentiation",
leading
attenuation
cancer
cell
stemness,
metastasis.
MoS2
nanosheets
moderate
photothermal
treatment
were
applied
target
surface
receptor
(i.e.,
CD44)
modulate
its
downstream
signaling
pathway.
This
forces
more
lose
mesenchymal
phenotype
adopt
an
epithelial,
less
state,
which
shows
attenuated
self-renewal
capacity,
response
anticancer
drugs,
invasiveness.
could
be
applicable
various
cancers
due
broad
availability
CD44
biomarker.
The
concept
using
nanomaterials
regulate
specific
cellular
activities
driving
CSCs
offers
new
avenue
for
treating
refractory
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2023,
Volume and Issue:
42(1)
Published: May 23, 2023
Abstract
Cancer
stem
cells
(CSCs)
are
the
key
“seeds”
for
tumor
initiation
and
development,
metastasis,
recurrence.
Because
of
function
CSCs
in
development
progression,
research
this
field
has
intensified
viewed
as
a
new
therapeutic
target.
Exosomes
carrying
wide
range
DNA,
RNA,
lipids,
metabolites,
cytosolic
cell-surface
proteins
released
outside
originating
through
fusion
multivesicular
endosomes
or
bodies
with
plasma
membrane.
It
become
evident
that
CSC‐derived
exosomes
play
significant
role
almost
all
“hallmarks”
cancer.
For
example,
from
can
maintain
steady
state
self-renewal
microenvironment
regulate
microenvironmental
distant
to
help
cancer
escape
immune
surveillance
induce
tolerance.
However,
value
underlying
molecular
mechanisms
still
largely
undefined.
To
provide
an
overview
possible
targeting
strategies,
we
summarize
relevant
progress,
highlight
potential
impact
detecting
on
treatment,
discuss
opportunities
challenges
based
our
experience
insights
area.
A
more
thorough
understanding
characteristics
may
open
avenues
clinical
diagnostic/prognostic
tools
therapies
prevent
resistance
relapse.
Cancer and Metastasis Reviews,
Journal Year:
2024,
Volume and Issue:
43(1), P. 293 - 319
Published: March 1, 2024
Metabolic
reprogramming,
a
hallmark
of
cancer,
allows
cancer
cells
to
adapt
their
specific
energy
needs.
The
Warburg
effect
benefits
in
both
hypoxic
and
normoxic
conditions
is
well-studied
reprogramming
metabolism
cancer.
Interestingly,
the
alteration
other
metabolic
pathways,
especially
lipid
has
also
grabbed
attention
scientists
worldwide.
Lipids,
primarily
consisting
fatty
acids,
phospholipids
cholesterol,
play
essential
roles
as
structural
component
cell
membrane,
signalling
molecule
reserves.
This
involves
aberrations
uptake,
synthesis
breakdown
lipids,
thereby
contributing
survival,
proliferation,
invasion,
migration
metastasis
cells.
development
resistance
existing
treatment
modalities
poses
major
challenge
field
therapy.
Also,
plasticity
tumor
was
reported
be
factor
for
resistance.
A
number
studies
implicated
that
dysregulated
contributes
associated
drug
Therefore,
it
important
understand
intricate
In
this
review,
we
mainly
focused
on
implication
disturbed
events
inducing
plasticity-mediated
addition,
discussed
concept
peroxidation
its
crucial
role
phenotypic
switching
ferroptosis
Elucidating
relationship
between
metabolism,
emergence
will
open
new
opportunities
develop
innovative
strategies
combinatorial
approaches
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 945 - 964
Published: Jan. 1, 2024
Abstract:
The
active
metabolite
of
irinotecan
(CPT-11),
7-ethyl-10-hydroxycamptothecin
(SN38),
is
100–
1000
times
more
than
CPT-11
and
has
shown
inhibitory
effects
on
a
range
cancer
cells,
including
those
from
the
rectal,
small
cell
lung,
breast,
esophageal,
uterine,
ovarian
malignancies.
Despite
SN38's
potent
anticancer
properties,
its
hydrophobicity
pH
instability
have
caused
substantial
side
activity
loss,
which
make
it
difficult
to
use
in
clinical
settings.
To
solve
above
problems,
construction
SN38-based
drug
delivery
systems
one
most
feasible
methods
improve
solubility,
enhance
stability,
increase
targeting
ability,
bioavailability,
therapeutic
efficacy
reduce
adverse
reactions.
Therefore,
based
mechanism
systems,
this
paper
reviews
SN38
polymeric
micelles,
liposomal
nanoparticles,
protein
conjugated
targeted
by
aptamers
ligands,
antibody-drug
couplings,
magnetic
targeting,
photosensitive
redox-sensitive
multi-stimulus-responsive
co-loaded
systems.
focus
review
nanocarrier-based
We
hope
provide
reference
for
translation
application
novel
medications.
Keywords:
SN38,
system,
