Deciphering the Matrisome: Extracellular Matrix Remodeling in Liver Cirrhosis and Hepatocellular Carcinoma DOI Open Access
Ram Prasad Chaulagain,

Aadil Mushtaq Padder,

H.K. Shrestha

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Language: Английский

Viscoelastic Mechanics of Living Cells DOI
Hui Zhou,

R. S. Liu,

Yizhou Xu

et al.

Physics of Life Reviews, Journal Year: 2025, Volume and Issue: 53, P. 91 - 116

Published: March 1, 2025

Language: Английский

Citations

0
Cancer cells impact the microrheology of endothelial cells during physical contact or through paracrine signalling DOI Creative Commons

Georgia M. Kefala,

Daria Tsvirkun,

Valérie Laurent

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 8, 2025

During the process of metastasis, cancer cells transmigrate through endothelial barrier vascular walls. Cancer interact with cells, leading to changes their mechanical properties. While this interaction has been extensively studied from perspective (CCs), properties endothelium remain underexplored, even though they may play a crucial role in regulating process. In study, we used microrheology AFM-based approach demonstrate that (ECs) are altered when cultured either CC-conditioned medium or direct contact cells. We found viscoelasticity ECs decreased diluted medium. Furthermore, cell at short times (less than 30 min) also showed significantly lower stiffness and viscoelastic moduli. parallel, observed reduction quantity actin fibers clusters within EC cytoskeleton, resulting less structured network facilitate CC transmigration. Overall, our findings indicated rheological can be directly physical CCs indirectly via CC-secreted substances. This suggests actively responds presence rather serving only as passive barrier.

Language: Английский

Citations

0
1,3,4-Oxadiazole Based EGFR Inhibitors as Anticancer Therapeutics: SAR Study and Binding Mode of Interaction Analysis DOI Creative Commons
Ajeya Samanta, Avik Maji, Abhik Paul

et al.

European Journal of Medicinal Chemistry Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100265 - 100265

Published: April 1, 2025

Language: Английский

Citations

0
Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity DOI Creative Commons
MeiLu McDermott,

R.B. Mehta,

Evanthia T. Roussos Torres

et al.

npj Systems Biology and Applications, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 10, 2025

Language: Английский

Citations

0
Deciphering the Matrisome: Extracellular Matrix Remodeling in Liver Cirrhosis and Hepatocellular Carcinoma DOI Open Access
Ram Prasad Chaulagain,

Aadil Mushtaq Padder,

H.K. Shrestha

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Language: Английский

Citations

0