Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
22, P. 551 - 566
Published: Oct. 31, 2022
Cancer
therapy
is
undergoing
a
paradigm
shift
toward
immunotherapy
focusing
on
various
approaches
to
activate
the
host
immune
system.
As
research
identify
appropriate
cells
and
anti-tumor
immunity
continues
expand,
scientists
are
looking
at
microbial
sources
given
their
inherent
ability
elicit
an
response.
Bacterial
extracellular
vesicles
(BEVs)
actively
studied
control
systemic
humoral
cellular
responses
instead
of
using
whole
microorganisms
or
other
types
(EVs).
BEVs
also
provide
opportunity
as
versatile
drug
delivery
carriers.
Unlike
mammalian
EVs,
have
already
made
it
clinic
with
meningococcal
vaccine
(Bexsero®).
However,
there
still
many
unanswered
questions
in
use
BEVs,
especially
for
chronic
systemically
administered
immunotherapies.
In
this
review,
we
address
opportunities
challenges
cancer
outlook
towards
development
BEV
products
that
can
ultimately
translate
clinic.
Cell Communication and Signaling,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: April 13, 2023
Abstract
Extracellular
vesicles
(EVs)
are
small,
membrane-bound
structures
that
released
from
cells
into
the
surrounding
environment.
These
can
be
categorized
as
exosomes,
microvesicles,
or
apoptotic
vesicles,
and
they
play
an
essential
role
in
intercellular
communication.
attracting
significant
clinical
interest
offer
potential
for
drug
delivery,
disease
diagnosis,
therapeutic
intervention.
To
fully
understand
regulation
of
communication
through
EVs,
it
is
to
investigate
underlying
mechanisms.
This
review
aims
provide
a
summary
current
knowledge
on
communications
involved
EV
targeting,
binding,
uptake,
well
factors
influence
these
interactions.
include
properties
cellular
environment,
recipient
cell.
As
field
EV-related
continues
expand
techniques
improve,
we
expect
uncover
more
information
about
this
complex
area,
despite
limitations
our
knowledge.
Journal of Extracellular Vesicles,
Journal Year:
2022,
Volume and Issue:
11(12)
Published: Dec. 1, 2022
Abstract
Extracellular
vesicles
(EVs)
represent
a
diverse
class
of
lipid
bilayer
membrane
released
by
both
animal
and
plant
cells.
These
ubiquitous
are
involved
in
intercellular
communication
transport
various
biological
cargos,
including
proteins,
lipids,
nucleic
acids.
In
recent
years,
interest
plant‐derived
EVs
has
increased
tremendously,
as
they
serve
scalable
sustainable
alternative
to
derived
from
mammalian
sources.
vitro
vivo
findings
have
demonstrated
that
these
(PDVs)
possess
intrinsic
therapeutic
activities
can
potentially
treat
diseases
improve
human
health.
addition,
PDVs
also
act
efficient
biocompatible
drug
carriers.
While
preclinical
studies
shown
promising
results,
there
still
several
challenges
knowledge
gaps
be
addressed
for
the
successful
translation
into
clinical
applications,
especially
view
lack
standardised
protocols
material
handling
PDV
isolation
This
review
provides
readers
with
quick
overview
current
understanding
research
on
PDVs,
critically
analysing
highlighting
immense
potential
novel
therapeutics
diseases.
It
is
expected
this
work
will
guide
scientists
address
currently
associated
promote
new
advances
plant‐based
solutions.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 4987 - 5009
Published: Sept. 1, 2023
Abstract:
Exosomes
are
small
extracellular
vesicles,
ranging
in
size
from
30–
150nm,
which
can
be
derived
various
types
of
cells.
In
recent
years,
mammalian-derived
exosomes
have
been
extensively
studied
and
found
to
play
a
crucial
role
regulating
intercellular
communication,
thereby
influencing
the
development
progression
numerous
diseases.
Traditional
Chinese
medicine
has
employed
plant-based
remedies
for
thousands
an
increasing
body
evidence
suggests
that
plant-derived
exosome-like
nanovesicles
(PELNs)
share
similarities
with
terms
their
structure
function.
this
review,
we
provide
overview
advances
study
PELNs
potential
implications
human
health.
Specifically,
summarize
roles
respiratory,
digestive,
circulatory,
other
Furthermore,
investigated
shortcomings
challenges
current
research
regarding
mechanism
action,
safety,
administration
routes,
isolation
extraction
methods,
characterization
identification
techniques,
as
well
drug-loading
capabilities.
Based
on
these
considerations,
propose
recommendations
future
directions.
Overall,
our
review
highlights
promising
area
research,
broad
treatment
We
anticipate
continued
interest
hope
summary
findings
will
stimulate
further
exploration
into
Keywords:
exosomes,
nanocarriers,
nanotherapeutics,
plants,
vesicles
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(5), P. 839 - 839
Published: May 15, 2023
Plant
cells
release
tiny
membranous
vesicles
called
extracellular
(EVs),
which
are
rich
in
lipids,
proteins,
nucleic
acids,
and
pharmacologically
active
compounds.
These
plant-derived
EVs
(PDEVs)
safe
easily
extractable
have
been
shown
to
therapeutic
effects
against
inflammation,
cancer,
bacteria,
aging.
They
promise
preventing
or
treating
colitis,
alcoholic
liver
disease,
even
COVID-19.
PDEVs
can
also
be
used
as
natural
carriers
for
small-molecule
drugs
acids
through
various
administration
routes
such
oral,
transdermal,
injection.
The
unique
advantages
of
make
them
highly
competitive
clinical
applications
preventive
healthcare
products
the
future.
This
review
covers
latest
methods
isolating
characterizing
PDEVs,
their
disease
prevention
treatment,
potential
a
new
drug
carrier,
with
special
attention
commercial
viability
toxicological
profile,
future
nanomedicine
therapeutics.
champions
formation
task
force
specializing
address
global
need
rigor
standardization
PDEV
research.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: March 29, 2023
Abstract
Background
The
past
few
years
have
witnessed
a
significant
increase
in
research
related
to
plant-derived
extracellular
vesicles
(PDEVs)
biological
and
medical
applications.
Using
biochemical
technologies,
multiple
independent
groups
demonstrated
the
important
roles
of
PDEVs
as
potential
mediators
involved
cell-cell
communication
exchange
bio-information
between
species.
Recently,
several
contents
been
well
identified
PDEVs,
including
nucleic
acids,
proteins,
lipids,
other
active
substances.
These
cargoes
carried
by
could
be
transferred
into
recipient
cells
remarkably
influence
their
behaviors
associated
with
human
diseases,
such
cancers
inflammatory
diseases.
Main
body
abstract
This
review
summarizes
latest
updates
regarding
focuses
on
its
role
nanomedicine
applications,
drug
delivery
strategies
develop
diagnostic
therapeutic
agents
for
clinical
management
especially
like
cancers.
Conclusion
Considering
unique
advantages,
high
stability,
intrinsic
bioactivity
easy
absorption,
further
elaboration
molecular
mechanisms
factors
driving
function
will
provide
new
horizons
treatment
disease.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(4), P. 1053 - 1053
Published: March 29, 2023
Plant-derived
exosome-like
nanoparticles
(PDENs)
comprise
various
bioactive
biomolecules.
As
an
alternative
cell-free
therapeutic
approach,
they
have
the
potential
to
deliver
nano-bioactive
compounds
human
body,
and
thus
lead
anti-inflammatory,
antioxidant,
anti-tumor
benefits.
Moreover,
it
is
known
that
Indonesia
one
of
herbal
centers
world,
with
abundance
unexplored
sources
PDENs.
This
encouraged
further
research
in
biomedical
science
develop
natural
richness
plants
as
a
source
for
welfare.
study
aims
verify
PDENs
purposes,
especially
regenerative
therapy
applications,
by
collecting
analyzing
data
from
latest
relevant
developments.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2236 - 2252
Published: Jan. 1, 2024
Plant-derived
exosomes
(PDEs)
show
promising
potential
to
be
developed
as
a
therapeutic
agent
against
cancer,
owing
their
multiple
advantages
such
low
toxicity,
biocompatibility,
availability,
affordability,
etc.
Materials Advances,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
pursuit
of
effective
drug
delivery
systems
is
critical
in
advancing
cancer
therapies,
particularly
the
realms
chemotherapy,
radiotherapy
and
immunotherapy.
Future Science OA,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Feb. 7, 2025
Aim
This
study
aims
to
explore
a
sustainable
and
scalable
approach
using
tomato
fruit-derived
sEVs
(TsEVs)
deliver
calcitriol
for
enhanced
anticancer
effects,
addressing
challenges
of
low
yield
high
costs
associated
with
mammalian
cell-derived
sEVs.
