Plant Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 211, P. 108674 - 108674
Published: April 30, 2024
Language: Английский
Citations
29Hydrazide-hydrazone/hydrazone as enabling linkers in anti-cancer drug discovery: A comprehensive review
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1307, P. 138012 - 138012
Published: March 11, 2024
Language: Английский
Citations
23Molecular crosstalk between polyphenols and gut microbiota in cancer prevention
Nutrition Research, Journal Year: 2024, Volume and Issue: 124, P. 21 - 42
Published: Jan. 27, 2024
Language: Английский
Citations
17Anticancer properties of sulforaphane: current insights at the molecular level
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: June 16, 2023
Sulforaphane (SFN) is an isothiocyanate with multiple biomedical applications. can be extracted from the plants of genus Brassica . However, broccoli sprouts are chief source sulforaphane and 20 to 50 times richer than mature as they contain 1,153 mg/100 g. SFN a secondary metabolite that produced result hydrolysis glucoraphanin (a glucosinolate) by enzyme myrosinase. This review paper aims summarize understand mechanisms behind anticancer potential sulforaphane. The data was collected searching PubMed/MedLine, Scopus, Web Science, Google Scholar. concludes provides cancer protection through alteration various epigenetic non-epigenetic pathways. It potent phytochemical safe consume minimal side effects. there still need for further research regarding development standard dose.
Language: Английский
Citations
30Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: Jan. 18, 2024
Abstract Venetoclax, an inhibitor that selectively targets B cell lymphoma-2 (BCL-2) has been approved for treating adult acute myeloid leukemia (AML) in combination with hypomethylating agents. However, its short duration of response and emergence resistance are significant issues. In this study, we found the sensitivity AML cells to venetoclax was considerably enhanced by ML385, ferroptosis factor nuclear transcription erythroid 2-related 2 (NRF2). Using samples, verified NRF2 target gene ferritin heavy chain 1 (FTH1) were highly expressed patients correlated poor prognosis. Downregulation could inhibit FTH1 expression significantly enhance venetoclax-induced labile iron pool lipid peroxidation. By contrast, overexpression or administration reactive oxygen species N-acetylcysteine vitamin E effectively suppress anti-AML effects ML385+venetoclax. Furthermore, inducer erastin increased venetoclax. Our study demonstrated inhibition death induced via pathway. Thus, ML385 may offer a favorable strategy treatment.
Language: Английский
Citations
13Synergistic therapeutic strategies and engineered nanoparticles for anti-vascular endothelial growth factor therapy in cancer
Life Sciences, Journal Year: 2024, Volume and Issue: 341, P. 122499 - 122499
Published: Feb. 10, 2024
Language: Английский
Citations
12A review on the composition, extraction and applications of phenolic compounds
Deleted Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
12Anti-inflammatory and antioxidant properties of Camellia sinensis L. extract as a potential therapeutic for atopic dermatitis through NF-κB pathway inhibition
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 18, 2025
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by immune dysregulation and excessive cytokine production. This study aimed to explore the potential of Camellia sinensis L. water extract (CSE) as treatment for AD impact CSE on responses in keratinocytes, particularly concerning production cytokines modulation signaling pathways relevant pathogenesis. was obtained via hot extraction from Ultra-high-performance liquid chromatography (UPLC) analyzed catechin caffeine content. Cell viability assessed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), polyphenol flavonoid content were determined. 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay measured antioxidant activity. Enzyme-Linked Immunosorbent Assay (ELISA), western blotting, Immunofluorescence (IF) assays examined cytokines, pathways, protein localization, respectively. Molecular docking compound binding inflammation-related proteins. UPLC identified six components including epigallocatechin (EGC) epicatechin (EC), (CF), (C), gallate (EGCG), (ECG). demonstrated significant reduction interleukin (IL)-2 IL-6 TNF-α/IFN-γ activated keratinocytes. Treatment inhibited mitogen-activated kinase (MAPK) pathway, which resulted decreased phosphorylation p38, Jun N-terminal (JNK), extracellular signal-regulated (ERK). Exposure TNF-α/IFN-γ- stimulated human keratinocytes (HaCaT) cells 200 µg/mL dependent inhibition p65 signal transducer activator transcription 1 (STAT-1) translocation cytosol nucleus, confirmed through immunofluorescence staining. simulations provided insights into underlying mechanisms action, supported its therapeutic agent AD. might be candidate efficacy conditions like Thus, based this evidence, authors suggest that should studied further anti-inflammatory activities topical application
Language: Английский
Citations
1A state-of-the-art review on the NRF2 in Hepatitis virus-associated liver cancer
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Nov. 9, 2023
Abstract According to a paper released and submitted WHO by IARC scientists, there would be 905,700 new cases of liver cancer diagnosed globally in 2020, with 830,200 deaths expected as direct result. Hepatitis B virus (HBV) hepatitis C (HCV), D (HDV) all play critical roles the pathogenesis hepatocellular carcinoma (HCC), despite rising prevalence HCC due non-infectious causes. Liver cirrhosis are devastating consequences HBV HCV infections, which widespread worldwide. Associated high mortality rate, these infections cause about 1.3 million annually primary globally. In addition causing insertional mutations viral gene integration, epigenetic alterations inducing chronic immunological dysfunction methods viruses turn hepatocytes into cancerous ones. While expanding our knowledge illness, identifying pathways also give possibilities for novel diagnostic treatment methods. Nuclear factor erythroid 2-related 2 (NRF2) activation is gaining popularity option oxidative stress (OS), inflammation, metabolic abnormalities. Numerous studies have shown that elevated Nrf2 expression linked HCC, providing more evidence HCC. This aberrant signaling drives cell proliferation, initiates angiogenesis invasion, imparts drug resistance. As result, this master regulator may promising target addition, common effect contributes pathogenesis, development, chronicity infection. However, certain suppress activity, helpful maintaining cellular homeostasis. paper, we discussed influence deregulation on life cycle associated HCV. We summed up mechanisms modulation deregulated viruses. Moreover, describe molecular mechanism modulated cancer, stem cells (LCSCs), caused
Language: Английский
Citations
18Melon peel flour: utilization as a functional ingredient in bakery products
Food & Function, Journal Year: 2024, Volume and Issue: 15(4), P. 1899 - 1908
Published: Jan. 1, 2024
Food by-products are a major concern with direct impact on the economy, society, and environment.
Language: Английский
Citations
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