Inflammasomes and autophagy in cancer: unlocking targeted therapies DOI
Jitendra Gupta, Mohammed H. Mohammed, Tawfeeq Alghazali

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Oncogenic potential of SARS-CoV-2—targeting hallmarks of cancer pathways DOI Creative Commons
Aishwarya Jaiswal,

Sanah Shrivastav,

Hemant R. Kushwaha

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 26, 2024

Language: Английский

Citations

4
Hybrid approach for drug-target interaction predictions in ischemic stroke models DOI

Jing-Jie Peng,

Yiyue Zhang, Ruifeng Li

et al.

Artificial Intelligence in Medicine, Journal Year: 2025, Volume and Issue: 161, P. 103067 - 103067

Published: Jan. 22, 2025

Language: Английский

Citations

0
Mechanism and role of H. pylori CagA-induced NLRP3 inflammasome in gastric cancer immune cell infiltration DOI Creative Commons
Chuandan Wan, Ping Wang,

Yeqiong Xu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Language: Английский

Citations

0
A Narrative Review of Prognostic Gene Signatures in Oral Squamous Cell Carcinoma Using LASSO Cox Regression DOI Creative Commons

Nur Fatinazwa Mohd Faizal,

Saptarsi Shai,

Bansi Savaliya

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 134 - 134

Published: Jan. 8, 2025

Oral squamous cell carcinoma (OSCC) is one of the most common malignancies head and neck (HNSCC). HNSCC recognized as eighth commonly occurring cancer globally in men. It essential to distinguish between cancers arising regions due significant differences their etiologies, treatment approaches, prognoses. As Cancer Genome Atlas (TCGA) dataset available HNSCC, survival analysis prognosis OSCC patients based on TCGA for discovering gene expression-based prognostic biomarkers limited. To address this paucity, we aimed provide comprehensive evidence by recruiting studies that have reported new biomarkers/signatures establish a model predict patients. Using PubMed search, identified 34 been using least absolute shrinkage selection operator (LASSO)-based Cox regression analyses signature related different pathways from past 4 years. Our review was focused summarizing these signatures implications targeted therapy FDA-approved drugs. Furthermore, conducted an LASSO signatures. findings revealed 13 correlated greater number regulatory T cells (Tregs) protective with increased recurrence-free overall rates. Conversely, two displayed opposing trend cases OSCC. We will also explore how dysregulation impacts immune status, promoting tumor evasion or, conversely, enhancing surveillance. Overall, insight future anti-cancer therapies potential associated poor

Language: Английский

Citations

0
IL-1β in Neoplastic Disease and the Role of Its Tumor-Derived Form in the Progression and Treatment of Metastatic Prostate Cancer DOI Open Access

Yetunde Oyende,

Luke J. Taus, Alessandro Fatatis

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 290 - 290

Published: Jan. 17, 2025

Since its discovery, IL-1β has taken center stage as a key mediator of very broad spectrum diseases revolving around immuno-mediated and inflammatory events. Predictably, the pleiotropic nature this cytokine in human pathology led to development targeted therapeutics with multiple treatment indications clinic. Following accumulated findings IL-1β’s central modulatory role immune system implication pathways cancer, use antagonists was first proposed then also pursued for oncology disorders. However, approach consistently relied on perceived need interfering synthesized secreted by cells. Herein, we discuss importance derived from cancer cells which impacts primary tumors, particularly metastatic lesions, separately addition more recognized immune-mediated To end, focus instrumental contribution establishment progression advanced prostate adenocarcinoma. Special emphasis is placed potential that standard-of-care strategies patients have unleashing expression production at sites. We conclude reviewing currently used blocking signaling propose rationale their concomitant treatments improve clinical outcomes cancer.

Language: Английский

Citations

0
Natural and synthetic potential drug leads for rheumatoid arthritis probing innovative target: mitochondrial dysfunction and NLRP3 inflammasome activation DOI

Urooj Iqbal,

Abdul Malik,

Lamyaa F. Ibrahim

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

Citations

0
Mechanisms of Plant Secondary Metabolites in Antitumor Activity: Insights into circRNA Modulation DOI
Tatiane Roquete Amparo, Tamires Cunha Almeida, Lucas Resende Dutra Sousa

et al.

Reference series in phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Jan. 1, 2025

Language: Английский

Citations

0
The intervention of NLRP3 inflammasome inhibitor: oridonin against azoxymethane and dextran sulfate sodium–induced colitis-associated colorectal cancer in male BALB/c mice DOI
Gurpreet Kaur, Priyanka Tiwari, Shivani Singla

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart DOI Creative Commons
Alessandra Ghigo, Pietro Ameri,

Aarti Asnani

et al.

European Journal of Heart Failure, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, new and often unexpected toxicities becoming apparent only after introduction. These unknown should be identified understood beforehand to better prepare patients physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models understand biological basis their cardiotoxicity. This scientific statement summarizes hitherto used, from in vitro two‐ three‐dimensional human systems small large animals, pinpoint molecular mechanisms behind cardiotoxicity new‐generation therapies, particularly immunotherapies, develop cardioprotective strategies. Furthermore, it discusses how have contributed provocative concept heart failure potentially tumorigenic discovery drugs both actions has revealed common mechanistic cancer. Finally, existing gaps between observations patients, these discrepancies affect regulatory pathways drug development process cardio‐oncology provides recommendations closing gaps.

Language: Английский

Citations

0
Steroid Constituents of Solidago canadensis alleviate LPS-induced inflammation via AMPK regulated Mitophagy/NLRP3 and NF-κB pathway DOI
Wenying Yin, Han Xue, Yongqi Zhang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177512 - 177512

Published: March 1, 2025

Language: Английский

Citations

0