Cited by Correction: The roles of different microRNAs in the regulation of cholesterol in viral hepatitis

The role of lipids and lipids lowering drugs in human papillomavirus (HPV) and HPV-associated cancers DOI

Ehsan Shabani,

Aida Hasanzadi, Omer Qutaiba B. Allela

et al.

Infectious Agents and Cancer, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 28, 2025

Both women and men are now confronted with the grave threat of cancers caused by human papillomavirus (HPV). It is estimated that 80% may encounter HPV over their lives. In preponderance cases involving anal, head neck, oral, oropharyngeal, penile, vaginal, vulvar, cervical malignancies, high-risk (HR-HPV) causative agent. 2019, believed to have been cause 620,000 new cancer in 70,000 worldwide. The bulk 530,000 (~ 270,000 fatalities) infection (86% cases, 88% deaths) happen poor nations each year. Lipid metabolism crucial development related HPV. One most noticeable metabolic abnormalities lipid reprogramming, which cells dysregulate obtain sufficient energy, building blocks for cell membranes, signaling molecules necessary invasion, metastasis, proliferation, survival. Moreover, proteins' stimulation production infected will probably a significant effect on oncogenesis. addition, lipids critical producing cellular epithelial-mesenchymal transition (EMT) process, therapy resistance HPV-related (HRCs). Therefore, essential HRC also be an important target approaches associated treatments during or development. This review study looked at role lipid-lowering drugs cancers.

Language: Английский

Citations

Identification of miRNA-mRNA Co-expression by network analysis in dengue virus infection DOI

Rajesh Das, Sangeetha Selvam,

Vigneshwar Suriya Prakash Sinnarasan

et al.

VirusDisease, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

In silico analysis revealed the prognostic potential of a miRNA panel in lung carcinoma DOI

Marwa Mohanad,

Rasha Fakhr Eldeen,

Hoda Shamloula

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 6 - 20

Published: Jan. 1, 2024

Background.This research aims to identify potential prognostic biomarkers for squamous cell lung carcinoma (LUSC) by implementing bioinformatics tools unveil the relationship between microRNAs (miRNAs) and LUSC, specifically identifying miRNAs their critical target genes. Methods.We employed Cancer Genome Atlas (TCGA)-LUSC dataset differentially expressed (DEmiRs) genes (DEGs) utilizing R software.Subsequently, a lasso Cox regression survival model was developed predict key DEmiRs.Their were predicted using miRDB repository.Venn diagram consensus shared these DEGs in TCGA-LUSC dataset.ClusetrProfiler analyzed Gene Ontology (GO) KEGG pathways comprehend genes' biological functions.The STRING database Cytoscape applications constructed gene proteinprotein interactions network.Results.Lasso 6 DEmiRs (hsa-miR1270, hsa-miR-1291, hsa-19b-2, hsa-miR-2277, hsa-miR-4791, hsa-miR-485) LUSC with 96.67% sensitivity 68.54% specificity.Venn retrieved 906 DEmiRs.These mainly related protein-binding, neuroactive ligand receptor interaction, retinoid metabolism, carcinogenesis, cycle, system development.Network analysis identified 19 crucial (SDC4, VCAN, BCAN, XYLT2, GPC1, GPC5, EGFR, EDNRA, EDN1, EDNRB, ERBB4, GNA14, GNAQ, CACNA1C, KCNQ1, KCND2, KCNH5, KCNB2, KCNQ5) linked carcinogenesis. Conclusion.We reliant on that accurately survival.These findings provide novel insights into carcinogenesis' underlying molecular mechanisms prognosis treatment.

Language: Английский

Citations

Human cytomegalovirus microRNAs: strategies for immune evasion and viral latency DOI

Mohammad Sabbaghian,

Hamidreza Gheitasi,

Manouchehr Fadaee

et al.

Archives of Virology, Journal Year: 2024, Volume and Issue: 169(8)

Published: July 6, 2024

Language: Английский

Citations

Advances in virus-host interaction research based on microfluidic platforms DOI

Cheng Wang,

Ji Wang, Dong Liu

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(12), P. 110302 - 110302

Published: July 31, 2024

Language: Английский

Citations

Effect of dyslipidemia on HBsAg clearance in nucleos(t)ide analogues-experienced chronic hepatitis B patients treated with peginterferon alfa DOI

Kaimin Song,

Lan Zhu Ren,

Yunyun Qian

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 11, 2024

While previous reports have shown that hepatitis B virus (HBV) infection affects lipid metabolism and vice versa, the impact of dyslipidemia on functional cure HBV following peginterferon alfa (PegIFNα) therapy remains unknown. Hence, this study aimed to investigate effect surface antigen (HBsAg) clearance develop a nomogram model for predicting patients whom PegIFNα is indicated. A total 160 nucleos(t)ide analogues (NAs)- experienced chronic (CHB) treated with (180 µg/week) were enrolled in study. The relationship between serum HBsAg was analysed. Univariate multivariate COX analyses used construct plot model. area under receiver operating characteristic curve (AUC) calibration evaluate discrimination model, respectively. After 48 weeks therapy, 33 cohort achieved clearance. indicated significantly associated an independent predictor (HR = 0.243, P 0.001). Kaplan-Meier survival show cumulative higher normolipidemic group than (log-rank test, 0.007). During treatment, triglyceride showed increasing trend, while levels cholesterol, high-density lipoprotein, low-density apolipoprotein A1 decreased. Dyslipidemia other indicators independently AUC at 36-week 48-week 0.879 0.856, demonstrated good calibration. can affect antiviral efficacy NAs-experienced CHB patients. Our findings suggest constructed using has predictive power may help physicians identify superior therapy.

Language: Английский

Citations

The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection DOI

Omer Qutaiba B. Allela,

Mohamad Ghazanfari Hashemi,

Shirin Heidari

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Dec. 19, 2024

The Flaviviridae family includes the dengue virus (DENV). About half of world's population is in danger because estimated 390 million infections and 96 symptomatic cases that occur each year. An effective treatment for fever (DF) does not yet exist. Therefore, a better knowledge how viral proteins virus-targeted medicines may exert distinct functions depending on exact cellular region addressed aid creating much-needed antiviral medications. Lipids facilitate coordination many replication phases, from entrance to dissemination. In addition, flaviviruses masterfully plan significant rearrangement host cell's lipid metabolism foster growth new viruses. Recent research has consistently shown significance certain classes flavivirus infections. For instance, DENV-infected cells, overall cholesterol (CHO) levels are only little altered, DENV significantly reduced when CHO inhibited. Moreover, statins decrease serotype 2 (DENV-2) titers, indicating prerequisite cycle. Furthermore, Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors now being evaluated human research. A pharmacological target management high PCSK9. suppression PCSK9 been proposed as possible defense against DENV. Numerous studies have generally recommended use lipid-lowering medications suppress As result, we investigated popular techniques this We also examined metabolism, lipids, receptors affect regulation. Lastly, looked at different This article discusses method's future based its benefits drawbacks.

Language: Английский

Citations

Correction: The roles of different microRNAs in the regulation of cholesterol in viral hepatitis DOI

Xuan Meng,

Yeganeh Eslami,

Ehsan Derafsh

et al.

Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 21, 2023

Language: Английский

Citations