The role and mechanism of NAT10‐mediated ac4C modification in tumor development and progression DOI Creative Commons

Zhuoran Gu,

Libin Zou,

Xinjian Pan

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Dec. 1, 2024

Abstract RNA modification has emerged as a crucial area of research in epigenetics, significantly influencing tumor biology by regulating metabolism. N‐acetyltransferase 10 (NAT10)‐mediated N4‐acetylcytidine (ac4C) modification, the sole known acetylation eukaryotic RNA, influences cancer pathogenesis and progression. NAT10 is only writer ac4C catalyzes acetyl transfer on targeted helps to improve stability translational efficiency ac4C‐modified RNA. highly expressed associated with poor prognosis pan‐cancers. Based its molecular mechanism biological functions, central factor tumorigenesis, progression, drug resistance, immune escape. Despite increasing focus ac4C, specific regulatory mechanisms remain elusive. The present review thoroughly analyzes current knowledge NAT10‐mediated cancer, highlighting broad influence gene expression biology. This also summarizes limitations perspectives identify new therapeutic targets advance treatment strategies.

Language: Английский

The promoting effect of the POU3F2/METTL16/PFKM cascade on glycolysis and tumorigenesis of hepatocellular carcinoma DOI Creative Commons

Ming Chen,

Yuan Yang,

Guangsheng Hu

et al.

Annals of Hepatology, Journal Year: 2025, Volume and Issue: unknown, P. 101776 - 101776

Published: Jan. 1, 2025

Deregulation of m

Language: Английский

Citations

1
Transcriptome-wide N6-methyladenosinem modifications analysis of growth and fumonisins production in Fusarium proliferatum causing banana crown rot DOI

Lihong Xie,

Linyan Feng,

Yan-Ling Ren

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140385 - 140385

Published: Jan. 1, 2025

Language: Английский

Citations

1
RNA N4‐acetylcytidine modification and its role in health and diseases DOI Creative Commons
Qiang Wang,

Yixiao Yuan,

Qiang Zhou

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Abstract N4‐acetylcytidine (ac4C) modification is a crucial RNA widely present in eukaryotic RNA. Previous studies have demonstrated that ac4C plays pivotal role viral infections. Despite numerous highlighting the strong correlation between and cancer progression, its detailed roles molecular mechanisms normal physiological processes progression remain incompletely understood. This review first outlines key regulatory enzyme mediating modification, N‐acetyltransferase 10 (NAT10), including critical regulating stability, transcriptional efficiency, translational fidelity. Additionally, it systematically summarizes essential functions of biological processes, stem cell fate determination, spermatogenesis oogenesis, embryonic development, cellular senescence, bone remodeling. Furthermore, this delves into central malignant proliferation, cycle arrest, EMT, drug resistance, death, metabolism, tumor immunotherapy. It also emphasizes potential NAT10 as prognostic biomarker therapeutic target for disease treatment. In summary, clarifies multifaceted both health explores NAT10‐targeted therapies with aim advancing research improving patient outcomes.

Language: Английский

Citations

0
Realgar induces apoptosis by inhibiting glycolysis via regulating STAT3 in myelodysplastic syndrome DOI
Tingting Xue,

Yuchen Tao,

Zong Wu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 341, P. 119339 - 119339

Published: Jan. 7, 2025

Language: Английский

Citations

0
A Coordinated Cascade Therapy‐Based Janus Fibrous Membrane Drives Bone Regeneration through Mediating the Transformation of Energy Metabolism Pathway DOI Open Access

X. Cheng,

Na Xu,

Hao Wu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Bone regeneration is synergistically regulated by growth factors, which are expressed in a coordinated cascade of events. An ideal guided bone membrane (GBRM) shall present barrier and antibacterial functions, promote osteogenesis through time‐controlled release factors. In this study, therapy‐based Janus fibrous fabricated coaxial electrospinning layer‐by‐layer self‐assembly technology (LBL). Specifically, the oriented PCL/PLGA fibers loaded with zinc oxide nanoparticles (ZnO NPs) designed as outer layer, randomly arranged core‐shell Gelatin/PLLA nanofibers employed inner layer to rapidly aFGF sustainedly BMP‐2. Results demonstrated that achieved multiple functions satisfy essential requirement regeneration, exhibited remarkable ability, function, osteoinductive ability. Interestingly, significant enhancement oxidative phosphorylation (OXPHOS) major energy supply pathway decisive factor drive osteogenic differentiation BMSCs induced membranes. This study provides novel strategy fabricate multifunctional membranes/scaffolds, displaying great potential applications tissue engineering. Besides, understanding synergistic mechanism factors on cellular metabolism process can provide deeper insights into factors‐mediated optimizing healing outcomes.

Language: Английский

Citations

0
N-terminal histone acetyltransferase NAA40 modulates osteosarcoma progression by controlling AGR2 expression DOI
Hanhua Wu, Xu Hua,

Yu-Nan Man

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 754, P. 151491 - 151491

Published: Feb. 14, 2025

Language: Английский

Citations

0
PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer DOI Creative Commons
Xiaomin Wu, Boshi Wang,

Yingjian Hou

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 356 - 356

Published: March 1, 2025

The acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is key regulator of pH sensing, but its progression underlying mechanisms remain unclear. In this study, we examined ASIC1 expression clinical tissues using immunohistochemistry immunofluorescence, correlating it with stages. HepG2 Li-7 cells were cultured supernatant conditions to mimic the microenvironment. Western blotting assessed glycolysis-related enzymes, siRNA transfections used investigate phosphofructokinase muscle-type (PFKM) survival. Our results showed that was significantly elevated correlated progression. Acidic increased both lines, survival, while knockdown reduced viability apoptosis, particularly under conditions. Moreover, PFKM silencing reversed advantage conferred ASIC1, confirming as downstream effector. Additionally, lactate dehydrogenase (LDH) (PFK) activity assays no significant changes, suggesting other regulatory may also be involved. These findings suggest ASIC1/PFKM pathway promotes environments, representing potential therapeutic target for disrupting adaptation malignancies.

Language: Английский

Citations

0
Paeonol inhibits the Glycolysis in oral squamous cell carcinoma though suppressing NAT10-mediated ac4C modification DOI Creative Commons

Kang Yang,

Baosen Yue,

Huan Tian

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 7, 2025

Language: Английский

Citations

0
Research progress on N6-methyladenosine and non-coding RNA in multiple myeloma DOI Creative Commons
Xiaoqi Sun,

Yongming Zhou,

Wenwei Zhu

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 25, 2025

N6-methyladenosine (m6A) and non-coding RNA (ncRNA) play important roles in the occurrence, development, prognosis of multiple myeloma (MM). They not only affect stemness, growth, apoptosis MM cells but also intervene proliferation, migration, invasion, even drug resistance. It is a prognostic factor for poor survival. Therefore, in-depth research on mechanisms m6A ncRNA significant diagnosis, treatment, MM.

Language: Английский

Citations

0
Improvement of MASLD and MASH by suppression of hepatic N-Acetyltransferase 10 DOI Creative Commons
Yanying Yang, Jie Lu, Yuejun Liu

et al.

Molecular Metabolism, Journal Year: 2024, Volume and Issue: 89, P. 102030 - 102030

Published: Sept. 17, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic steatohepatitis (MASH) are characterized by excessive triglyceride accumulation in the liver. However, due to an incomplete understanding of its pathogenesis, more efforts needed identify specific effective treatments. N4-acetylcytidine (ac4C) is a newly discovered RNA modification regulate mRNA. N-acetyltransferase 10 (NAT10) has not been fully explored MASLD MASH.

Language: Английский

Citations

2