CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis DOI Creative Commons

Yao Lu,

Huang Wu, Yuanyuan Luo

et al.

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Language: Английский

Proteomics Suggests the Role of Cxcl12 Secreted by Hucmscs in the Treatment of Lipopolysaccharide-Acute Lung Injury DOI
Jinfeng Cui, Xiaozhi Wang,

Liqing Luo

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
CD177 neutrophils exacerbate septic lung injury via the NETs/AIM2 pathway: An experimental and bioinformatics study DOI
Fuquan Wang, Yan Zhang, Miaomiao Sun

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 151, P. 114292 - 114292

Published: Feb. 24, 2025

Language: Английский

Citations

0
Targeting neutrophil dysfunction in acute lung injury: insights from active components of Chinese medicine DOI

Saiya Ye,

Lin Ma, Yayun Chi

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156664 - 156664

Published: March 1, 2025

Language: Английский

Citations

0
Serum ferritin is a superior biomarker for evaluating disease activity and kidney injury compared with C-reactive protein in anti-neutrophil cytoplasmic antibody-associated vasculitis DOI

Liyuan Xie,

Xinyun Qiu,

Yu-Nan Li

et al.

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Wogonin alleviates sepsis-induced acute lung injury by modulating macrophage polarization through the SIRT1-FOXO1 pathways DOI Creative Commons

Jinlin Ge,

Huanhuan Yang,

Ningning Yu

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 88, P. 102400 - 102400

Published: May 5, 2024

Sepsis-induced acute lung injury is a common and severe complication of sepsis, for which effective treatments are currently lacking. Previous studies have demonstrated the influence wogonin in treating (ALI). However, its precise mechanism action remains unclear. To delve deeper into mechanisms underlying wogonin's impacts sepsis-induced injury, we established mouse sepsis model through cecal ligation puncture conducted further cell experiments using lipopolysaccharide-treated MH-S MLE-12 cells to explore potential ALI. Our results revealed that significantly increased survival rate mice, alleviated pulmonary pathological damage inflammatory infiltration, activated SIRT1-FOXO1 pathway. Additionally, suppressed release pro-inflammatory factors by M1 macrophages induced activation M2 anti-inflammatory factors. Further vitro confirmed effectively inhibited macrophage polarization pathway, thereby mitigating changes caused In summary, our study regulated M1/M2 attenuating response improving This discovery provided solid mechanistic foundation therapeutic use ALI, shedding new light on strategies treatment

Language: Английский

Citations

1
ROS responsive nanozyme loaded with STING silencing for the treatment of sepsis-induced acute lung injury DOI

Y. F. Zhang,

Lingyang Chen, Lin Feng

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 493, P. 117155 - 117155

Published: Nov. 12, 2024

Language: Английский

Citations

1
Neutrophil extracellular traps promote the activation of the NLRP3 inflammasome and PBMCs pyroptosis via the ROS-dependent signaling pathway in Kawasaki disease DOI
Jing Jin, Yan Zhao, Yuying Fang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 145, P. 113783 - 113783

Published: Dec. 7, 2024

Language: Английский

Citations

1
Identification of sepsis-related genes by integrating eQTL data with Mendelian randomization analysis DOI

Chao Wen,

Dongliang Yang, Hongyan Guo

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Abstract Background Sepsis is defined as a life-threatening organ dysfunction caused by dysfunctional host response to infection and associated with high mortality. However, there currently no effective treatment strategy for sepsis. Methods We obtained GSE263789, GSE54514 GSE66099 from the Gene Expression Omnibus (GEO) database selected differentially expressed genes (DEGs). extracted expression quantitative trait loci (eQTL) exposure sepsis GWAS outcome IEU Open database. MR analysis was used assess causality between eQTL The overlapping of DEGs significant were identified key genes. Enrichment immune cell infiltration performed verified in validation cohort. Results 18 sepsis-related genes, including 11 up-regulated (SEMA4A, LRPAP1, FAM89B, TOMM40L, SLC22A15, MACF1, MCTP2, NTSR1, PNKD, ACTR10, CPNE3) 7 down-regulated (IKZF3, TNFRSF25, HDC, HCP5, LYRM4, TFAM, RPS15A). analyses showed that these are mainly involved biological processes related inflammatory response. Compared healthy controls, abundance neutrophils activated mast cells increased group. Most correlated cells, neutrophils, CD8 T resting NK plasma memory B macrophage subtypes. Conclusion By combining bioinformatics analysis, we sepsis, enhancing our understanding genetic pathogenesis providing new insights into therapeutic targets

Language: Английский

Citations

0
CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis DOI Creative Commons

Yao Lu,

Huang Wu, Yuanyuan Luo

et al.

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Language: Английский

Citations

0