Genes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 1615 - 1615
Published: Dec. 17, 2024
The
tumor
secretome
comprises
the
totality
of
protein
factors
secreted
by
various
cell
components
within
microenvironment,
serving
as
primary
medium
for
signal
transduction
between
cells
and
stromal
cells.
deletion
or
mutation
p53
gene
leads
to
alterations
in
cellular
secretion
characteristics,
contributing
construction
microenvironment
a
non-autonomous
manner.
This
review
discusses
critical
roles
mutant
regulating
remodel
drive
progression,
influence
plasticity
cancer-associated
fibroblasts
(CAFs)
well
dynamics
immunity
focusing
on
both
expression
pathways.
aim
is
provide
new
insights
targeted
cancer
therapies.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: June 26, 2024
Abstract
Adipose-derived
stem
cells
(ADSCs)
are
promising
in
regenerative
medicine.
Their
proliferation,
survival
and
activation
influenced
by
specific
signals
within
their
microenvironment,
also
known
as
niche.
The
cell
niche
is
regulated
complex
interactions
between
multiple
types.
When
transplanted
a
area,
ADSCs
can
secrete
several
immunomodulatory
factors.
At
the
same
time,
tumor
microenvironment
influence
behavior,
modulating
proliferation
ability
to
differentiate
into
phenotype.
Whitin
this
context,
we
exposed
plasma
samples
derived
from
human
patients
diagnosed
with
prostate
cancer
(PC),
or
precancerous
lesions
(PL),
benign
prostatic
hyperplasia
(BPH)
for
4,
7
10
days.
We
then
analyzed
expression
of
main
stemness-related
markers
cell-cycle
regulators.
measured
cytokine
production
polyamine
secretion
culture
medium
evaluated
morphology
collagen
confocal
microscopy.
results
obtained
study
show
significant
changes
samples,
especially
presence
plasma,
suggesting
important
implications
use
development
new
treatments
application
Genes,
Journal Year:
2024,
Volume and Issue:
15(12), P. 1615 - 1615
Published: Dec. 17, 2024
The
tumor
secretome
comprises
the
totality
of
protein
factors
secreted
by
various
cell
components
within
microenvironment,
serving
as
primary
medium
for
signal
transduction
between
cells
and
stromal
cells.
deletion
or
mutation
p53
gene
leads
to
alterations
in
cellular
secretion
characteristics,
contributing
construction
microenvironment
a
non-autonomous
manner.
This
review
discusses
critical
roles
mutant
regulating
remodel
drive
progression,
influence
plasticity
cancer-associated
fibroblasts
(CAFs)
well
dynamics
immunity
focusing
on
both
expression
pathways.
aim
is
provide
new
insights
targeted
cancer
therapies.
