International review of cell and molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 25 - 66
Published: Oct. 4, 2024
Language: Английский
Molecular and Cellular Probes, Journal Year: 2025, Volume and Issue: 79, P. 102007 - 102007
Published: Jan. 6, 2025
Language: Английский
Citations
1
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
The invasion and metastasis of pancreatic cancer (PC) are key factors contributing to disease progression poor prognosis. This process is primarily driven by EMT, which has been the focus recent studies highlighting role long non-coding RNAs (lncRNAs) as crucial regulators EMT. However, mechanisms lncRNAs influence invasive multifaceted, extending beyond EMT regulation alone. review aims characterize affecting in cancer. We summarize regulatory roles across multiple molecular pathways highlight their translational potential, considering implications for clinical applications diagnostics therapeutics. focuses on three principal scientific themes. First, we orchestrate various signaling pathways, such TGF-β/Smad, Wnt/β-catenin, Notch, regulate changes associated with thereby enhancing cellular motility invasivenes. Second, effects autophagy ferroptosis discuss exosomal tumor microenvironment behavior neighboring cells promote cell invasion. Third, emphasize RNA modifications (such m6A m5C methylation) stabilizing capacity mediate PC. Lastly, potential these findings, emphasizing inherent challenges using biomarkers therapeutic targets, while proposing prospective research strategies.
Language: Английский
Citations
1
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1159 - 1177
Published: May 20, 2024
Ferroptosis, a recently identified type of non-apoptotic cell death, triggers the elimination cells in presence lipid peroxidation and an iron-dependent manner. Indeed, ferroptosis-stimulating factors have ability suppressing antioxidant capacity, leading to accumulation reactive oxygen species (ROS) subsequent oxidative death cells. Ferroptosis is involved pathophysiological basis different maladies, such as multiple cancers, among which female-oriented malignancies attracted much attention recent years. In this context, it has also been unveiled that non-coding RNA transcripts, including microRNAs, long RNAs, circular RNAs regulatory interconnections with ferroptotic flux, controls pathogenic development diseases. Furthermore, potential employing these transcripts therapeutic targets during onset female-specific neoplasms modulate ferroptosis become research hotspot; however, molecular mechanisms functional alterations still require further investigation. The current review comprehensively highlights its association focus on how crosstalk affects pathogenesis malignancies, from breast cancer ovarian, cervical, endometrial neoplasms, suggesting novel decelerate even block expansion tumors.
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141945 - 141945
Published: March 1, 2025
Language: Английский
Citations
0
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110389 - 110389
Published: March 1, 2025
Language: Английский
Citations
0
Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155944 - 155944
Published: March 1, 2025
Language: Английский
Citations
0
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: April 17, 2025
Understanding the core principles of ovarian cancer has been significantly improved through exploration Ferroptosis, a type cell death triggered by iron that leads to an increase in lipid peroxides. Current research shed light on critical functions non-coding RNAs, such as circRNAs, lncRNAs, and miRNAs, regulating ferroptosis cancer. The aim this paper is comprehensively analyze how ncRNAs influence development cells. In-depth undertaken understand intricate ways which regulate essential elements ferroptosis, including management peroxidation levels. We also investigate their significant involvement progression cellular demise. It should be emphasized can impact synthesis crucial proteins, GPX4, key contributor defense against oxidation, ACSL4, involved formation. In addition, we examine correlation between well-known pathways associated with oxidative stress death. consequences these discoveries are noteworthy, since focusing particular could potentially render cells more vulnerable effectively combating drug resistance problems. This discussion highlights growing significance governing potential useful biomarkers treatment targets for intend promote additional into controlling based current findings, ultimate goal informing targeted therapeutic strategies improving long-term outcomes individuals suffering from OC.
Language: Английский
Citations
0
Human Molecular Genetics, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Abstract Circular RNAs (circRNAs) are emerging as important regulatory molecules in both host and viral systems, acting microRNA sponges, protein decoys or scaffolds, templates for translation. Host-derived circRNAs increasingly recognized their roles immune responses, while virus-encoded circRNAs, especially those from DNA viruses, have been shown to modulate cellular machinery favor replication evasion. Recently, RNA were also discovered, but evidence suggests that they might be generated using a different mechanism compared the produced viruses. This review highlights recent advances our understanding of virus-derived with focus on biological contributions pathogenesis. Furthermore, we discuss potential biomarkers application therapeutic targets scaffolds RNA-based therapies. Understanding host-virus interactions offers novel insights into biology opens new avenues strategies against diseases associated cancers.
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 3, 2025
Cervical cancer progresses through distinct precancerous stages, making early screening and intervention crucial for prevention. However, conventional modalities, such as cytology HPV testing, face challenges related to sensitivity, specificity, resource dependency. Circular RNAs (circRNAs), owing their high stability tissue-specific expression, have emerged promising biomarkers, though role in cervical carcinogenesis remains underexplored. In particular, the clinical utility of circRNAs optimizing diagnosis has yet be established. This study aimed investigate dynamic expression profiles across various stages progression identify potential biomarkers enhance detection. CircRNA sequencing was performed on tissues spanning normal epithelium (NCE), high-grade squamous intraepithelial lesions (HSIL), cell carcinoma (CSCC). Functional assays, including viability, colony formation, apoptosis, were assess oncogenic circPOLD1 its interaction with YBX1 cells. BaseScope immunohistochemistry (IHC) applied tissue microarrays clincial validation ROC curve analysis evaluated diagnostic performance serum a liquid biopsy marker. profiling revealed progressive increase from NCE HSIL CSCC. Mechanistically, functioned an oncogene by binding phosphorylating YBX1, activating AKT/mTOR/HIF-1α pathway glycolysis-driven tumorigenesis. IHC confirmed stage-specific elevation lesions. The circPOLD1/YBX1 multi-marker panel demonstrated superior performance, achieving AUC 0.951 LSIL+ 0.817 HSIL+ Furthermore, levels exhibited disease underscoring non-invasive biomarker. synergistically drive exhibit patterns. Their combined detection significantly enhanced accuracy monitoring. successful application highlights immediate translational these paving way refined risk stratification, improved therapeutic targeting, reduced burden intervention.
Language: Английский
Citations
0
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155457 - 155457
Published: July 6, 2024
Language: Английский
Citations
2