Single-cell sequencing technology to characterize stem T-cell subpopulations in acute T-lymphoblastic leukemia and the role of stem T-cells in the disease process DOI Creative Commons
Yan Li, Zhenwei Jia, Xiaoyan Liu

et al.

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Precursor T-cell acute lymphoblastic leukemia (Pre-T ALL) is a malignant neoplastic disease in which T-cells proliferate the bone marrow. Single-cell sequencing technology could identify characteristic cell types, facilitating study of therapeutic mechanisms Pre-T ALL.

Language: Английский

Targeting the “tumor microenvironment”: RNA-binding proteins in the spotlight in colorectal cancer therapy DOI
Yiwei Zhang, Yujun Zhang, Jingjing Song

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111876 - 111876

Published: March 16, 2024

Language: Английский

Citations

8
Enhancing immunogenicity and release of in situ-generated tumor vesicles for autologous vaccines DOI
Jinhu Chen,

Caili Zhao,

Jing Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113614 - 113614

Published: March 1, 2025

Language: Английский

Citations

0
The Application of Dendritic Cells Vaccines in Tumor Therapy and Their Combination with Biomimetic Nanoparticles DOI Creative Commons
Tong Zhu, Yuexin Li, Yutao Wang

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 337 - 337

Published: March 21, 2025

Dendritic cells (DCs) act as a bridge between innate and adaptive immunity by presenting antigens to effector immune have shown broad application potential in tumor immunotherapy. However, the clinical translation of DC vaccines encounters significant challenges, such immunosuppressive microenvironment (TME) sub-optimal function vaccine efficacy vivo. In this review, our investigation has uncovered latest developments their cancer immunotherapy, with special emphasis on integration nanotechnology. Several types nanomaterials, including protein cage nanoparticles (NPs), biomimetic NPs, targeted multifunctional been developed enhance antigen presentation ability DCs stimulatory effects T cells. addition, we also summarized synergistic anti-cancer checkpoint inhibitors, chemotherapy, radiotherapy. recent advances nanotechnology made it possible develop novel biomarkers that can capacity stimulate These not only improve accuracy precision design but provide new insights into understanding mechanisms DC-mediated response. Despite challenges pertaining technical complexities individual adaptation production vaccines, personalized immunotherapy based is expected become an important part treatment rapid biotechnology immunology. This review provides perspectives solutions for optimal therapy.

Language: Английский

Citations

0
Deciphering the roles of the HMGB family in cancer: Insights from subcellular localization dynamics DOI Creative Commons

Junqing Jiang,

Mengyu Sun, Yufei Wang

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 78, P. 85 - 104

Published: July 14, 2024

The high-mobility group box (HMGB) family consists of four DNA-binding proteins that regulate chromatin structure and function. In addition to their intracellular functions, recent studies have revealed involvement as extracellular damage-associated molecular patterns (DAMPs), contributing immune responses tumor development. HMGB promotes tumorigenesis by modulating multiple processes including proliferation, metabolic reprogramming, metastasis, evasion, drug resistance. Due the predominant focus on HMGB1 in literature, little is known about remaining members this family. This review summarizes structural, distributional, well functional similarities distinctions among family, followed a comprehensive exploration roles We emphasize distributional hierarchy at both organizational subcellular levels, with relationship microenvironment (TIME), aiming prospect potential strategies for anticancer therapy.

Language: Английский

Citations

1
The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies DOI Creative Commons
Dongqi Li, Xiangyu Chu, Weikang Liu

et al.

RNA Biology, Journal Year: 2024, Volume and Issue: 22(1), P. 1 - 14

Published: Dec. 24, 2024

The crosstalk between the tumour immune microenvironment (TIME) and cells promote evasion resistance to immunotherapy in gastrointestinal (GI) tumours. Post-transcriptional regulation of genes is pivotal GI tumours progression, RNA-binding proteins (RBPs) serve as key regulators via their domains. RBPs may exhibit either anti-tumour or pro-tumour functions by influencing TIME through modulation mRNAs non-coding RNAs expression, well post-transcriptional modifications, primarily N6-methyladenosine (m6A). Aberrant RBPs, such HuR YBX1, typically enhances escape impacts prognosis patients. Further, while targeting offers a promising strategy for improving cancers, mechanisms which regulate these remain poorly understood, therapeutic application still its early stages. This review summarizes current advances exploring roles regulating expression effect on tumours, then providing theoretical insights RBP-targeted cancer therapies.

Language: Английский

Citations

1
Single-cell sequencing technology to characterize stem T-cell subpopulations in acute T-lymphoblastic leukemia and the role of stem T-cells in the disease process DOI Creative Commons
Yan Li, Zhenwei Jia, Xiaoyan Liu

et al.

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Precursor T-cell acute lymphoblastic leukemia (Pre-T ALL) is a malignant neoplastic disease in which T-cells proliferate the bone marrow. Single-cell sequencing technology could identify characteristic cell types, facilitating study of therapeutic mechanisms Pre-T ALL.

Language: Английский

Citations

0