End Binding Proteins: Drivers of Cancer Progression DOI Open Access

Dhakshmi Sasankan,

Renu Mohan

Cytoskeleton, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Cancer, a complex and heterogeneous disease, continues to be major global health concern. Despite advancements in diagnostics therapeutics, the aggressive nature of certain cancers remain significant challenge, necessitating deeper understanding underlying molecular mechanisms driving their severity progression. Cancer progression depend on cellular properties such as cell migration, division, shape changes, intracellular transport, all which are driven by dynamic microtubules. Dynamic microtubules, turn, regulated an array proteins that influence stability growth. Among these regulators, End Binding (EB) stand out critical orchestrators microtubule dynamics at growing plus ends. Beyond fundamental role normal functions, recent research has uncovered compelling evidence linking EB pathogenesis various diseases, including cancer As field advances, clinical implication aggressiveness become increasingly evident. This review aims comprehensively explore microtubule-associated influencing cancer. We also discuss potential significance biomarker for diagnosis prognosis target therapeutic intervention.

Language: Английский

Peptide-Mediated Liquid-Liquid Phase Separation and Biomolecular Condensates DOI

Guangle Li,

Chengqian Yuan, Xuehai Yan

et al.

Soft Matter, Journal Year: 2025, Volume and Issue: 21(10), P. 1781 - 1812

Published: Jan. 1, 2025

Peptide-mediated liquid–liquid phase separation (LLPS) underpins the formation of dynamic biomolecular condensates, regulated by diverse molecular interactions, and highlights potential applications in drug delivery synthetic biology.

Language: Английский

Citations

0
The role of liquid-liquid phase separation in the disease pathogenesis and drug development DOI Open Access

Yingjie Zhang,

Chengkang Jin,

Xiaoling Xu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117448 - 117448

Published: Sept. 21, 2024

Language: Английский

Citations

3
Spontaneous Self‐Organized Order Emerging From Intrinsically Disordered Protein Polymers DOI Creative Commons
Sergio Acosta,

Pablo Rodríguez‐Alonso,

Viktoriya Chaskovska

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 1, 2025

ABSTRACT Intrinsically disordered proteins (IDPs) are that, despite lacking a defined 3D structure, capable of adopting dynamic conformations. This structural adaptability allows them to play not only essential roles in crucial cellular processes, such as subcellular organization or transcriptional control, but also coordinating the assembly macromolecules during different stages development. Thus, order artificially replicate complex processes morphogenesis and their dynamics, it is have materials that recapitulate plasticity IDPs. In this regard, intrinsically protein polymers (IDPPs) emerge promising for engineering synthetic condensates creating hierarchically self‐assembled materials. IDPPs exhibit remarkable properties use biofabrication, functional versatility, tunable sequence order–disorder, ability undergo liquid–liquid phase separation (LLPS). Recent research has focused on harnessing intrinsic disorder design architectures with tailored properties. Taking advantage stimuli‐responsiveness degree disorder, researchers developed innovative strategies control self‐assembly IDPPs, resulting creation organized structures intricate morphologies. review, we aim provide an overview latest advances application IDPP‐based materials, shedding light fundamental principles supramolecular assembly, discussing biomedical nanobiotechnological fields.

Language: Английский

Citations

0
The Mitochondria Chronicles of Melatonin and ATP: Guardians of Phase Separation DOI Creative Commons
Doris Loh, Russel J. Reıter

Mitochondrial Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Phase separation is a thermodynamic process used by all living organisms since the origin of life to rapidly assemble and disassemble membraneless condensates in response changes exogenous endogenous stress conditions. For ∼4.5 billion years, three major domains depended upon high chemical potential adenosine triphosphate (ATP) harness nonequilibrium reactions that govern formation suppression organelles via phase separation. Melatonin enhances unique chemistry ATP water, promoting solubilization moiety effect, supporting survival early an anoxic environment. Eukaryotes, including dinoflagellates plants, can produce melatonin extreme levels under as compensation for inadequate optimal regulation responses dependent The production mitochondria enables fine-tuning dynamics modulate proteins associated with production, biogenesis degradation, membrane dynamics, gene transcription, mitophagy, unfolded protein response, apoptosis/survival mitochondria. Exogenous application mitochondrial synergy, attenuating aberrant dysfunction disease.

Language: Английский

Citations

2
End Binding Proteins: Drivers of Cancer Progression DOI Open Access

Dhakshmi Sasankan,

Renu Mohan

Cytoskeleton, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Cancer, a complex and heterogeneous disease, continues to be major global health concern. Despite advancements in diagnostics therapeutics, the aggressive nature of certain cancers remain significant challenge, necessitating deeper understanding underlying molecular mechanisms driving their severity progression. Cancer progression depend on cellular properties such as cell migration, division, shape changes, intracellular transport, all which are driven by dynamic microtubules. Dynamic microtubules, turn, regulated an array proteins that influence stability growth. Among these regulators, End Binding (EB) stand out critical orchestrators microtubule dynamics at growing plus ends. Beyond fundamental role normal functions, recent research has uncovered compelling evidence linking EB pathogenesis various diseases, including cancer As field advances, clinical implication aggressiveness become increasingly evident. This review aims comprehensively explore microtubule-associated influencing cancer. We also discuss potential significance biomarker for diagnosis prognosis target therapeutic intervention.

Language: Английский

Citations

0