Journal of Central Nervous System Disease,
Journal Year:
2024,
Volume and Issue:
16
Published: Oct. 23, 2024
The
field
of
cancer
neuroscience
has
rapidly
evolved,
shedding
light
on
the
complex
interplay
between
nervous
system
and
cancer,
with
a
particular
focus
relationship
central
(CNS)
gliomas.
Recent
advancements
have
underscored
critical
influence
CNS
activity
glioma
progression,
emphasizing
roles
neurons
neuroglial
cells
in
both
onset
evolution
This
review
meticulously
explores
primary
communication
pathways
gliomas,
encompassing
neuro-glioma
synapses,
paracrine
mechanisms,
extracellular
vesicles,
tunneling
nanotubes,
integrative
CNS-immune-glioma
axis.
It
also
evaluates
current
emerging
therapeutic
interventions
aimed
at
these
proposes
forward-looking
perspectives
for
research
this
domain.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12524 - 12524
Published: Nov. 21, 2024
Glioblastoma
Multiforme
(GBM)
is
the
most
aggressive
primary
tumor
of
Central
Nervous
System
(CNS)
with
a
low
survival
rate.
The
malignancy
GBM
sustained
by
bidirectional
crosstalk
between
cells
and
Tumor
Microenvironment
(TME).
This
mechanism
intercellular
communication
mediated,
at
least
in
part,
release
exosomes.
Glioma-Derived
Exosomes
(GDEs)
work,
indeed,
as
potent
signaling
particles
promoting
progression
brain
tumors
inducing
proliferation,
invasion,
migration,
angiogenesis
resistance
to
chemotherapy
or
radiation.
Given
their
nanoscale
size,
exosomes
can
cross
blood-brain
barrier
(BBB),
thus
becoming
not
only
promising
biomarker
predict
diagnosis
prognosis
but
also
therapeutic
target
treat
GBM.
In
this
review,
we
describe
structural
functional
characteristics
involvement
development,
diagnosis,
treatment.
addition,
discuss
how
be
modified
used
target/drug
delivery
system
for
clinical
applications.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Journal Year:
2024,
Volume and Issue:
1880(1), P. 189244 - 189244
Published: Dec. 11, 2024
In
the
past
years,
increasing
attention
has
been
paid
to
role
of
extracellular
vesicles
(EVs)
as
mediators
intercellular
communication
in
cancer.
These
small
size
particles
mediate
transfer
important
bioactive
molecules
involved
malignant
initiation
and
progression.
Hypoxia,
or
low
partial
pressure
oxygen,
is
recognized
a
remarkable
feature
solid
tumors
demonstrated
exert
profound
impact
on
tumor
prognosis
therapeutic
efficacy.
Indeed,
high-pitched
growth
rate
chaotic
neovascular
architecture
that
embodies
results
reduction
oxygen
within
microenvironment
(TME).
response
oxygen-deprived
conditions,
cells
their
surrounding
milieu
develop
homeostatic
adaptation
mechanisms
contribute
establishment
pro-tumoral
phenotype.
Latest
evidence
suggests
hypoxic
surrounds
bulk
may
be
clincher
for
observed
elevated
levels
circulating
EVs
cancer
patients.
Thus,
it
proposed
play
mediating
conditions.
This
review
focuses
EVs-mediated
crosstalk
established
between
immune,
endothelial,
stromal
cell
populations,
TME.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1469 - 1469
Published: July 3, 2024
The
immune
system
is
a
highly
complex
and
tightly
regulated
that
plays
crucial
role
in
protecting
the
body
against
external
threats,
such
as
pathogens,
internal
abnormalities,
like
cancer
cells.
It
undergoes
development
during
fetal
stages
continuously
learns
from
each
encounter
with
allowing
it
to
develop
immunological
memory
provide
wide
range
of
protection.
Over
time,
after
numerous
encounters
years
functioning,
can
begin
show
signs
erosion,
which
commonly
named
immunosenescence.
In
this
review,
we
aim
explore
how
responds
initial
antigens
handles
persistent
stimulations
throughout
person's
lifetime.
Our
understanding
has
greatly
benefited
advanced
technologies
flow
cytometry.
context,
will
discuss
valuable
contribution
cytometry
enhancing
our
knowledge
behavior
aging,
specific
focus
on
T-cells.
Moreover,
expand
discussion
cytometry-based
assessment
extracellular
vesicles,
recently
discovered
communication
channel
biology,
their
implications
for
functioning.
Journal of Central Nervous System Disease,
Journal Year:
2024,
Volume and Issue:
16
Published: Oct. 23, 2024
The
field
of
cancer
neuroscience
has
rapidly
evolved,
shedding
light
on
the
complex
interplay
between
nervous
system
and
cancer,
with
a
particular
focus
relationship
central
(CNS)
gliomas.
Recent
advancements
have
underscored
critical
influence
CNS
activity
glioma
progression,
emphasizing
roles
neurons
neuroglial
cells
in
both
onset
evolution
This
review
meticulously
explores
primary
communication
pathways
gliomas,
encompassing
neuro-glioma
synapses,
paracrine
mechanisms,
extracellular
vesicles,
tunneling
nanotubes,
integrative
CNS-immune-glioma
axis.
It
also
evaluates
current
emerging
therapeutic
interventions
aimed
at
these
proposes
forward-looking
perspectives
for
research
this
domain.
