Exploring the role of mitophagy-related genes in breast cancer: subtype classification and prognosis prediction DOI Creative Commons
Lizhao Wang,

Nan Mei,

Jianpeng Li

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2664 - 2682

Published: Jan. 1, 2024

Breast cancer (BC) is the most common among women globally and poses leading health threat to worldwide, with persistently high incidence rates. Mitophagy a selective autophagy process that specifically targets mitochondria within cell, maintaining cellular energy balance metabolic by identifying degrading damaged mitochondria. Although there an understanding of relationship between mitophagy cancer, specific mechanisms remain unclear due complexity diversity mitophagy, suggesting it could be effective more targeted therapeutic approach for BC.

Language: Английский

Macrophage polarization and its impact on idiopathic pulmonary fibrosis DOI Creative Commons

Zhouling Ge,

Yong Q. Chen,

Leikai Ma

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing in the lungs and ultimately resulting respiratory failure high risk of death. Macrophages play crucial role immune system, showing flexibility by transforming into either pro-inflammatory (M1) or anti-inflammatory (M2) macrophages when exposed to different stimuli, impacting development IPF. Recent research has indicated polarization onset progression M1 secrete inflammatory cytokines agents early damage fibrosis, while M2 support tissue healing releasing cytokines. Developing novel treatments for IPF relies on thorough comprehension processes involved macrophage The review outlines regulation its impact IPF, with goal investigating possible therapeutic benefits advancement

Language: Английский

Citations

12
Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion DOI Creative Commons

Xixi Liu,

Kenneth K.W. To,

Qinsong Zeng

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark cancer. Antitumor refers to innate adaptive immune responses that regulate development proliferation. Tumor evasion represents major hindrance effective anticancer treatment. Extracellular vesicles (EVs) are nano-sized lipid-bilayer-enclosed particles secreted extracellular space by all cell types. They critically involved numerous biological functions including intercellular communication. Tumor-derived (TEVs) can transport variety cargo modulate cells microenvironment (TME). This review provides latest update about how evade surveillance exploiting TEVs. First, biogenesis EVs cargo-sorting machinery discussed. Second, differentiation, activation, function via TEVs illustrated. Last but not least, novel antitumor strategies reverse escape summarized.

Language: Английский

Citations

1
Bushen Jiedu Formula alleviates colorectal cancer progression through reducing lncRPPH1 in tumor-derived extracellular vesicles DOI

Shiyun Shao,

Lei Tang,

Wenqing Rong

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156390 - 156390

Published: Jan. 13, 2025

Language: Английский

Citations

0
Tumour-derived exosomal miR-205 promotes ovarian cancer cell progression through M2 macrophage polarization via the PI3K/Akt/mTOR pathway DOI Creative Commons
Liuqing He, Quan Chen, Xiaoying Wu

et al.

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 15, 2025

Tumour-associated macrophages (TAMs) are the most abundant immune cells in tumour environment and considered similar to M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of cross-talk between tumour-associated can development metastasis ovarian by mediating macrophage polarization. However, exact mechanisms underlying communication (OC) during OC progression remain unclear. Here, we demonstrated that high expression miR-205 was associated with infiltration, affected prognosis patients. Importantly, tumour-derived could be transported from via exosomes promote cell invasion inducing M2-like Animal experiments further confirmed exosomal miR-205-induced accelerated vivo. Mechanistically, downregulated PTEN, activating PI3K/AKT/mTOR signalling pathway, is critical for These results reveal plays a pivotal role polarization within microenvironment, highlighting its potential therapeutic target treatment. This study not only enhances our understanding interactions but also opens new avenues targeted therapies against cancer.

Language: Английский

Citations

0
The role of macrophages in liver metastasis: mechanisms and therapeutic prospects DOI Creative Commons
Qin Yuan,

Linlin Jia,

Jiahua Yang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Metastasis is a hallmark of advanced cancer, and the liver common site for secondary metastasis many tumor cells, including colorectal, pancreatic, gastric, prostate cancers. Macrophages in microenvironment (TME) promote cell through various mechanisms, angiogenesis immunosuppression, play unique role development metastasis. are affected by variety factors. Under conditions hypoxia increased acidity TME, more factors now found to polarization macrophages M2 type, exosomes amino acids. M2-type secretion such as VEGF, IL-1β, TGF-β1. subjected multiple regulatory mechanisms. They also interact with cells within co-regulate certain conditions, creation an immunosuppressive microenvironment. This interaction promotes metastasis, drug resistance, immune escape. Based on advent single-cell sequencing technology, further insights into macrophage subpopulations may help exploring new therapeutic targets future. In this paper, we will focus how affect well other each other, investigate mechanisms involved their potential targets.

Language: Английский

Citations

0
miRNA-1229-5p promotes migration and invasion and suppresses apoptosis of endometrial cells via the STMN1/p38 MAPK axis in endometriosis DOI Creative Commons
Lusha Liu, Lixian Wang, Na Hao

et al.

Gene, Journal Year: 2025, Volume and Issue: 950, P. 149385 - 149385

Published: March 2, 2025

Emerging evidence suggests that aberrantly expressed microRNAs (miRNAs) participate in endometriosis pathogenesis. miR-1229-5p participates the pathogenesis of several disease, but its precise role and mechanism is unclear. Endometrial tissues were obtained from patients with healthy controls. RT-qPCR western blotting employed to detect expression levels genes proteins, respectively. Transcriptome sequencing luciferase reporter assay utilized identify target miR-1229-5p. CCK-8, transwell assay, wound healing flow cytometry performed evaluate functional roles Finally, clinical significance was furtherly analyzed. MiR-1229-5p upregulated ectopic endometrium ovarian (n = 60) compared normal endometria controls 40), also served as an indicator for severity. STMN1 identified by experiments, significantly downregulated endometrium. Functionally, overexpression promoted migration, invasion, inhibited apoptosis ESCs Ishikawa cells. Meanwhile, upregulation facilitated protein Bcl-2, MMP2, MMP9, N-cadherin, ZEB1, repressed Bax E-cadherin. Whereas downregulation exerted opposite effects. Importantly, could partially reverse effects upregulation. Mechanistically, activates p38 mitogen-activated kinase (p38 MAPK) signaling via targeting STMN1. The newly miR-1229-5p-STMN1-p38 MAPK axis illustrates molecular progression offers a potential therapeutic treating endometriosis.

Language: Английский

Citations

0
Exosomal miR-92a-3p modulates M2 macrophage polarization in colorectal cancer: implications for tumor migration and angiogenesis DOI
Wei Zhao,

Yudan Wu,

Yixiao Wang

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 10, 2025

Language: Английский

Citations

0
Bioinspired Membrane‐Based Cancer Vaccines for Immunotherapy: Progress and Perspectives DOI
Ying Miao,

Jianlin Ge,

Longyi Zheng

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Cancer vaccines hold promise for tumor immunotherapy, with their success hinging on effective systems to boost anti‐tumor immunity. Biological membranes are not only a delivery vehicle but also source of antigens and adjuvants, garnering growing interest in vaccine research. This review starts an introduction the composition mechanisms cancer describes sources, advantages/disadvantages, engineering strategies, applications these membrane‐based platforms development. offers critical analysis discusses further direction platform view clinical translation immunotherapy.

Language: Английский

Citations

0
Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches DOI Creative Commons

Arefeh Zabeti Touchaei,

Sogand Vahidi

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 20, 2024

Language: Английский

Citations

2
Identifying subtypes and developing prognostic models based on N6-methyladenosine and immune microenvironment related genes in breast cancer DOI Creative Commons
Lizhao Wang, Jianpeng Li,

Nan Mei

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 18, 2024

Breast cancer (BC) is the most prevalent in women globally. The tumor microenvironment (TME), comprising epithelial cells and stromal elements, vital for breast development. N6-methyladenosine (m6A) modification plays a key role RNA metabolism, influencing its various aspects such as stability translation. There notable link between m6A methylation immune TME, although this relationship complex not fully deciphered. In research, BC expression clinicopathological data from TCGA were scrutinized to assess profiles, mutations, CNVs of 31 genes microenvironment-related genes, examining their correlations, functions, prognostic impacts. Lasso Cox regression identified constructing nomogram. Single-cell analyses mapped distribution patterns these cell We investigated associations gene-derived risk scores factors like infiltration, checkpoints, TMB, CSC indices, drug response. As complement computational analyses, vitro experiments conducted confirm patterns. included regulatory discovered correlation extent infiltration. Subsequently, 7-gene score was generated, encompassing HSPA2, TAP1, ULBP2, CXCL1, RBP1, STC2, FLT3. It observed that low-risk group exhibited better overall survival (OS) BC, with higher but lower mutational burden (TMB) stem (CSC) well IC50 values commonly used drugs. To enhance clinical applicability, age stage incorporated into score, more comprehensive nomogram constructed predict OS. This validated demonstrated good predictive performance, area under curve (AUC) 1-year, 3-year, 5-year OS being 0.848, 0.807, 0.759, respectively. Our findings highlight profound impact prognostic-related on response outcomes, suggesting modulation m6A-immune pathway could offer new avenues personalized treatment potentially improve outcomes.

Language: Английский

Citations

1