A Comprehensive Analysis of the Cuproptosis-Related Gene GCSH in Pan-Cancer with a Focus on Colorectal Cancer DOI Creative Commons
Xianwen Guo,

Rong-e Lei,

Jiao Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Background GCSH, a gene associated with cuproptosis, has been implicated in various cancers, although its role remains incompletely understood. This study aims to conduct comprehensive analysis of GCSH across multiple cancer types elucidate tumorigenesis. Methods expression was analyzed 33 using data from TCGA database. Associations the tumor microenvironment and prognostic value were evaluated. scRNA-seq colorectal (CRC) used assess different cell types. Clinical CRC tissues, blood samples, lines utilized for validation. Functional assays drug sensitivity tests performed further GCSH. Results varied among notably higher levels CRC. demonstrated significant correlations 22 immune cells cancers. Generally, showed negative correlation scores checkpoint genes. Prognostic revealed that outcomes adrenocortical carcinoma, hepatocellular stomach adenocarcinoma, external cohort results did not consistently support these findings. Validation clinical samples confirmed elevated indicated both cancerous within tissues compared normal tissues. pathway analyses identified key biological roles identified. Conclusions exerts multifaceted specific cancers is significantly The identifies functions suggests potential sensitivities.

Language: Английский

Ferroptosis: Molecular perspective, cellular influence, cancer manifestation, and therapeutic potentials DOI
Pawan Kumar Pandey,

Saurabh Bhorkade,

Shikha Jha

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 105998 - 105998

Published: July 31, 2024

Language: Английский

Citations

2
Cuproptosis engineered nanomaterials: The silent warrior against cancer DOI

Tenzin Sonam Dongsar,

Tenzin Tsering Dongsar,

Nazim Nasir

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 39, P. 102305 - 102305

Published: July 6, 2024

Language: Английский

Citations

1
Cuproptosis nanomedicine in cancer therapy: Novel insights and future perspectives DOI
Lu Wang,

J. Piao,

Haisong Qi

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216284 - 216284

Published: Oct. 28, 2024

Language: Английский

Citations

1
Targeting regulated cell death pathways in cancers for effective treatment: a comprehensive review DOI Creative Commons
Ruchi Saxena,

Catherine F. Welsh,

You‐Wen He

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 15, 2024

Cancer is a complex disease characterized by specific “mission-critical” events that drive the uncontrolled growth and spread of tumor cells their offspring. These are essential for advancement disease. One main contributors to these dysregulation cell death pathways—such as apoptosis, necroptosis, ferroptosis, autophagy, pyroptosis, cuproptosis, parthanatos and—allows cancer avoid programmed continue proliferating unabated. The different pathways in cancers provide useful targets treatment. This review examines recent progresses preclinical clinical development targeting dysregulated To develop effective therapies, it identify target mission-critical prevent from timely death. By precisely crucial events, researchers can therapies with maximum impact minimal side effects. A comprehensive understanding molecular cellular mechanisms underlying regulated will further highly personalized treatments.

Language: Английский

Citations

1
Cuproptosis: an emerging domain for copper-based nanomaterials mediated cancer therapy DOI
Fan Zhao,

Zhuangzhuang Zhao,

Hao Gao

et al.

MedMat., Journal Year: 2024, Volume and Issue: 1(2), P. 74 - 94

Published: Dec. 1, 2024

Cuproptosis, a newly discovered copper-dependent mode of cell death, has received extensive attention in the field cancer therapy due to its specific activation pathway. Rapid accumulation large amounts copper ions within cells achieve overload is key activating cuproptosis. Advanced nanotechnology offers considerable promise for delivering cells, which copper-based nanomaterials have been proposed evoke cuproptosis-mediated therapy. However, it still great challenge induce specifically tumors and efficiently activate subsequent cuproptosis-related molecular pathways. Therefore, necessary summarize strategies used effectively or amplify cuproptosis based on currently developed nanomaterials, providing ideas design future. In this review, that can be are systematically classified selection. Subsequently, sensitization using provided therapeutic efficiency. Meanwhile, combination therapies maximizing treatment efficacy delineated. Ultimately, remaining challenges feasible future directions use tumor also discussed.

Language: Английский

Citations

0
Advances in Cuproptosis of Hepatocellular Carcinoma DOI Open Access
Yuxia Gao, Ligong Lu

Journal of Biosciences and Medicines, Journal Year: 2024, Volume and Issue: 12(08), P. 167 - 181

Published: Jan. 1, 2024

Language: Английский

Citations

0
Review to Elucidate the Correlation between Cuproptosis-Related Genes and Immune Infiltration for Enhancing the Detection and Treatment of Cervical Cancer DOI Open Access
Pratibha Pandey, Seema Ramniwas, Shivam Pandey

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10604 - 10604

Published: Oct. 1, 2024

Copper is a vital trace element in oxidized and reduced forms. It plays crucial roles numerous biological events such as redox chemistry, enzymatic reactions, mitochondrial respiration, iron metabolism, autophagy, immune modulation. Maintaining the balance of copper body essential because its deficiency excess can be harmful. Abnormal metabolism has two-fold impact on development tumors cancer treatment. Cuproptosis form cell death that occurs when there excessive body, leading to proteotoxic stress activation specific pathway mitochondria. Research been conducted advantageous role ionophores chelators management. This review presents recent progress understanding cuproptosis, molecular mechanisms involved using for targeted therapy cervical cancer. Integrating metals minerals into nanoparticulate systems promising approach controlling invasive tumors. Therefore, we have also included concise overview nanoformulations targeting cells. offers comprehensive insights correlation between cuproptosis-related genes infiltration, well prognosis These findings valuable developing advanced clinical tools enhance detection treatment

Language: Английский

Citations

0
Psychiatric Symptoms in Wilson’s Disease—Consequence of ATP7B Gene Mutations or Just Coincidence?—Possible Causal Cascades and Molecular Pathways DOI Open Access
Grażyna Gromadzka, Agnieszka Antos,

Zofia Sorysz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12354 - 12354

Published: Nov. 18, 2024

Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism. The genetic defect in WD affects the

Language: Английский

Citations

0
A Comprehensive Analysis of the Cuproptosis-Related Gene GCSH in Pan-Cancer with a Focus on Colorectal Cancer DOI Creative Commons
Xianwen Guo,

Rong-e Lei,

Jiao Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Background GCSH, a gene associated with cuproptosis, has been implicated in various cancers, although its role remains incompletely understood. This study aims to conduct comprehensive analysis of GCSH across multiple cancer types elucidate tumorigenesis. Methods expression was analyzed 33 using data from TCGA database. Associations the tumor microenvironment and prognostic value were evaluated. scRNA-seq colorectal (CRC) used assess different cell types. Clinical CRC tissues, blood samples, lines utilized for validation. Functional assays drug sensitivity tests performed further GCSH. Results varied among notably higher levels CRC. demonstrated significant correlations 22 immune cells cancers. Generally, showed negative correlation scores checkpoint genes. Prognostic revealed that outcomes adrenocortical carcinoma, hepatocellular stomach adenocarcinoma, external cohort results did not consistently support these findings. Validation clinical samples confirmed elevated indicated both cancerous within tissues compared normal tissues. pathway analyses identified key biological roles identified. Conclusions exerts multifaceted specific cancers is significantly The identifies functions suggests potential sensitivities.

Language: Английский

Citations

0