BMC Pregnancy and Childbirth,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Dec. 26, 2024
Delivery
mode
has
been
linked
to
child
health,
e.g.,
allergic
disease.
However,
it
remains
unclear
whether
protein
and
metabolite
differences
across
different
delivery
modes
may
underlie
development.
A
cohort
comprising
16
spontaneous
onset
vaginal
(VD),
prelabor
cesarean
on
maternal
request
(CS),
8
intrapartum
section
(Intra_CS)
women
were
analyzed
using
label-free
proteomic
untargeted
metabolomics
assays
amniotic
fluid
cord
blood
samples,
respectively.
We
used
weighted
gene
co-expression
network
analyses
(WGCNA)
identify
modules
of
highly
correlated
proteins
or
metabolites
that
associated
with
related
clinical
traits.
KEGG
enrichment
performed
investigate
the
biological
function
identified
modules.
Integrative
multiomics
analysis
was
employed
examine
interplay
between
metabolic
interactions.
Compared
CS
group,
metabolomic
profiles
similar
Intra_CS
VD
groups
in
our
study.
did
not
any
enriched
pathways
immune
development
could
influence
risk
diseases
offspring
modes.
we
seven
duration
from
rupture
membranes
full
dilation
cervix,
actin
cytoskeleton
module
significantly
enriched.
subclasses
including
C21
steroids,
steroid
sulfates,
oxysterols.
data
suggested
labor,
encompassing
cytoskeleton,
NADP
process,
nicotinate,
nicotinamide
metabolism
fluid,
hormone
biosynthesis
pathway
blood.
Differences
hormones
according
proteomics
more
indicative
labor
process.
These
findings
guide
future
studies
delivery-associated
biochemical
pathways.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 270 - 270
Published: Feb. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Cell Communication and Signaling,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 27, 2025
Abstract
Efferocytosis
is
a
mechanism
by
which
phagocytes
efficiently
clear
apoptotic
cells,
averting
their
secondary
necrosis
and
the
subsequent
release
of
potentially
immunogenic
or
cytotoxic
substances
that
can
trigger
strong
immune
inflammatory
responses.
During
efferocytosis,
metabolic
pathways
are
transformed,
which,
along
with
catabolism
cargo,
affect
function
state.
Extensive
apoptosis
occurs
during
placental
development,
some
studies
reported
immunomodulatory
effects
efferocytosis
at
maternal–fetal
interface.
The
dysregulation
strongly
linked
to
pregnancy
complications
such
as
preeclampsia
recurrent
spontaneous
abortion.
In
this
review,
we
discuss
mechanisms
its
relationships
metabolism
inflammation.
We
also
highlight
roles
professional
non-professional
in
interface
impact
on
outcomes
explore
relevant
regulatory
factors.
These
insights
expected
guide
future
basic
research
clinical
strategies
for
identifying
efferocytosis-related
molecules
potential
predictors
therapeutic
targets
obstetric
diseases.
World Journal of Gastrointestinal Oncology,
Journal Year:
2025,
Volume and Issue:
17(3)
Published: Feb. 13, 2025
There
is
still
no
effective
treatment
for
pancreatic
cancer,
one
of
the
deadliest
malignancies
among
gastrointestinal
diseases.
Jiang
et
al
demonstrated
presence
senescent
cancer-associated
fibroblasts
(CAFs)
in
cancer
tissues,
supporting
use
CAFs
as
potential
anti-cancer
targets.
The
study
indicated
that
a
natural
plant-derived
compound
resveratrol
can
reverse
CAF
phenotype
and
decrease
growth,
migration,
invasiveness
cells.
Notably,
might
be
involved
regulating
epithelial-to-mesenchymal
transition
tumor
microenvironment.
This
editorial
shares
insights
on
future
investigation
signaling
cells
microenvironment,
discusses
resveratrol-based
perspectives.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 17, 2025
Distant
metastasis
is
one
of
the
important
factors
affecting
prognosis
lung
cancer
patients.
Extracellular
vesicles
(EVs)
play
an
role
in
occurrence,
development,
and
cancer.
However,
it
currently
unclear
whether
EVs
BALF
are
involved
distant
tumor
metastasis.
we
collected
bronchoalveolar
lavage
fluid
(BALF)
from
patients
with
metastatic
non-metastatic
non-small
cell
(NSCLC)
to
isolate
exosomes,
which
were
then
characterized
by
nanoparticle
tracking
analysis
(NTA)
transmission
electron
microscopy
(TEM),
followed
comprehensive
metabolomic
proteomic
ultimately
construct
a
prediction
model
for
Our
research
has
found
that
NSCLC
rich
EVs,
have
typical
morphology
size.
There
significant
differences
protein
expression
metabolite
types
between
those
without
Sphingolipid
metabolism
pathways
may
be
key
factor
influencing
NSCLC.
Subsequently,
constructed
predictive
based
on
differentially
expressed
proteins
identified
proteomics.
This
been
proven
high
value.
The
multi-omic
generated
this
study
provided
global
overview
molecular
changes,
provide
useful
insight
into
therapy
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 2923 - 2923
Published: March 24, 2025
Understanding
the
modulation
of
specific
immune
cells
within
tumor
microenvironment
(TME)
offers
new
hope
in
cancer
treatments,
especially
immunotherapies.
In
recent
years,
and
resistance
to
immunotherapy
have
become
critical
challenges
treatments.
However,
novel
strategies
for
emerged
as
promising
approaches
oncology
due
vital
roles
immunomodulators
regulating
progression
metastasis
modulating
immunological
responses
standard
care
With
progress
immuno-oncology,
a
growing
number
mechanisms
are
being
uncovered,
offering
potential
enhanced
clinical
near
future.
Thus,
gaining
comprehensive
understanding
broader
context
is
essential.
Herein,
we
particularly
summarize
paradoxical
role
tumor-related
cells,
focusing
on
how
targeted
their
actions
modulated
by
immunotherapies
overcome
immunotherapeutic
cells.
We
also
highlight
molecular
employed
tumors
evade
long-term
effects
agents,
rendering
them
ineffective.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9193 - 9193
Published: Aug. 24, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)—and
its
worse
form,
metabolic-associated
steatohepatitis
(MASH),
characterised
by
inflammation
and
damage—corresponds
to
the
liver’s
involvement
in
metabolic
syndrome,
which
constitutes
an
economic
burden
for
healthcare
systems.
However,
biomolecular
pathways
that
contribute
are
not
completely
clear.
Abnormalities
of
bone
metabolism
frequent
people
affected
disease,
with
reduced
density
increased
risk
fracture.
Receptor
activator
NF-κB
(RANK),
receptor
ligand
(RANKL),
osteoprotegerin(OPG)
critical
regulators
metabolism,
performing
pleiotropic
effects,
may
have
potential
disorders
like
MASLD,
resulting
a
topic
great
interest
intrigue.
This
narrative
review
aims
investigate
this
role
implications
MASLD
development
progression
hepatocellular
carcinoma,
represents
worst
complication.
