The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease DOI Creative Commons
Yibing Wang, Tong Li, Fengyu Wang

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 21(2), P. 632 - 657

Published: Dec. 31, 2024

Aging is a complex biological process that involves the gradual decline of cellular, tissue, and organ functions.In kidney, aging manifests as tubular atrophy, glomerulosclerosis, progressive renal function decline.The critical role senescence-associated macrophage in diseases, particularly kidney increasingly recognized.During this process, macrophages exhibit range pro-damage response to senescent tissues cells, while themselves also significantly influences disease progression, creating bidirectional regulatory between macrophages.To explore mechanism, review will elucidate origin, characteristic, phenotype, secretory phenotype (SASP), extracellular vesicles from senescence cell-engulfment suppression (SCES), context disease.Additionally, it discuss characteristics macrophage, such common markers, changes autophagy, metabolism, gene regulation, phagocytosis, antigen presentation, exosome secretion, along with their physiological pathological impacts on tissue cells.Furthermore, exploring therapies drugs modulate or eliminate cells may help slow progression damage.

Language: Английский

Epigenetic regulation of macrophage function in kidney disease: New perspective on the interaction between epigenetics and immune modulation DOI Open Access

Ruizhi Tan,

Qianrong Bai, Lingfei Jia

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117842 - 117842

Published: Jan. 13, 2025

Language: Английский

Citations

0
A bibliometric analysis of exosomes in aging from 2007 to 2023 DOI Creative Commons

Zenghui Niu,

Mengge Cui,

Yingkun Fu

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 22, 2025

Background Aging is the primary factor contributing to development of aging-related diseases. As research on exosomes continues advance, its relationship with aging and diseases has become a hot topic This article analyzes hotspots in diseases, aiming fill gap bibliometric this field help researchers better understand current status future trends both fundamental clinical field. Methods The articles were retrieved exported from WoSCC December 18, 2023. visual analysis countries regions, institutions, authors, references, keywords was conducted using VOSviewer 1.6.18, CiteSpace 6.2.R7, Bibliometrix. Results included 1628 articles. China United States emerged as top two leading A total 2,321 institutions 78 regions primarily led by States. Both Kapogiannis D Goetzl E active authors Thery C, Valadi H, Raposo G important promoters C proposed method differential centrifugation density gradient extract exosomes. H discovered cells could send RNA-messages each other loading them into exosome-vesicles. journal highest number International Journal Molecular Sciences , while PLoS One most frequently cited journal. keyword revealed that will possibly focus “inflammation, cellular senescence, angiogenesis, insulin resistance, Alzheimer's disease.” Conclusion We identified through analysis. present study provides valuable new perspectives history also offering guidance for directions.

Language: Английский

Citations

0
Regulatory Roles of Exosomes in Aging and Aging-Related Diseases DOI

Nanyin Xiao,

Li Qiao, Guangyu Liang

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Crosstalk between macrophages and adjacent cells in AKI to CKD transition DOI Creative Commons
Yanping Lin, Qian Yang,

Rui Zeng

et al.

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: March 20, 2025

Acute kidney injury (AKI), triggered by ischemia, sepsis, toxicity, or obstruction, is marked a rapid impairment of renal function and could lead to the initiation advancement chronic disease (CKD). The concept AKI CKD transition has gained much interest. Despite series studies highlighting diverse roles macrophages in immune response following AKI, intricate mechanisms macrophage-driven cell-cell communication remains incompletely understood. In this review, we introduce dynamic phenotype change under different stages injury. Importantly, present novel perspectives on extensive interaction with adjacent cells, including tubular epithelial vascular endothelial fibroblasts, other cells via soluble factors, extracellular vesicles, direct contact, facilitate from CKD. Additionally, summarize potential therapeutic strategies based adverse macrophage-neighboring cell crosstalk.

Language: Английский

Citations

0
Extracellular Vesicles in Renal Inflammatory Diseases: Revealing Mechanisms of Extracellular Vesicle-Mediated Macrophage Regulation DOI Open Access
Jie Wei, Zheng Xie, Xiaodong Kuang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3646 - 3646

Published: April 12, 2025

Renal inflammatory diseases are a group of severe conditions marked by significant morbidity and mortality. Extracellular vesicles (EVs), as facilitators intercellular communication, have been recognized pivotal regulators renal diseases, significantly contributing to these modulating immune responses among other mechanisms. This review highlights the intricate mechanisms through which EVs modulate macrophage-kidney cell interactions regulating macrophages, principal cells within milieu. regulation subsequently influences pathophysiology such acute kidney injury chronic disease. Furthermore, understanding offers novel opportunities alleviate consequences associated with diseases. In addition, we summarize therapeutic landscape based on EV-mediated macrophage regulatory mechanisms, highlighting potential biomarkers targets well challenges limitations translating therapies into clinical practice.

Language: Английский

Citations

0
Innate immune cells in acute and chronic kidney disease DOI
Xiao‐Ming Meng, Li Wang, David J. Nikolic‐Paterson

et al.

Nature Reviews Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Exosomes from renal cells and macrophages: Bidirectional communication in the pathogenesis of kidney disease DOI
Jing Gao, Pan Chen, Wenjing Zhao

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 192, P. 156961 - 156961

Published: May 17, 2025

Language: Английский

Citations

0
Advancements in Research on Mesenchymal Stem-Cell-Derived Exosomal miRNAs: A Pivotal Insight into Aging and Age-Related Diseases DOI Creative Commons
Minglei Huang,

Ye Liu,

Longze Zhang

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1354 - 1354

Published: Oct. 24, 2024

Mesenchymal stem cells (MSCs) are capable of differentiating into various cell types and play a crucial role in repairing aging tissues diseased organs. Aging manifests as gradual loss cellular, tissue, organ function, leading to the progression pathologies. Exosomes (Exos) extracellular vesicles secreted by cells, which maintain cellular homeostasis, clear debris, facilitate communication between This review provides comprehensive summary mechanisms for synthesis sorting MSC-Exo miRNAs summarizes current research status MSCs-Exos mitigating age-related diseases. It delves underlying molecular mechanisms, encompass antioxidative stress, anti-inflammatory response, promotion angiogenesis. Additionally, this also discusses potential challenges future strategies advancing miRNA-based therapies treatment

Language: Английский

Citations

2
Current Understanding of Cardiovascular Calcification in Patients with Chronic Kidney Disease DOI Open Access
Sijie Chen, Ri‐Ning Tang, Bi-Cheng Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10225 - 10225

Published: Sept. 23, 2024

The burden of chronic kidney disease (CKD) is increasing, posing a serious threat to human health. Cardiovascular calcification (CVC) one the most common manifestations CKD, which significantly influences morbidity and mortality patients. manifestation CVC an unusual accumulation mineral substances containing calcium phosphate. main component hydroxyapatite. Many cells are involved in this process, such as smooth muscle (SMCs) endothelial cells. osteogenic process initiated by complex mechanisms metabolic disorders phosphorus minerals, inflammation, extracellular vesicles, autophagy, micro-RNAs with variety signaling pathways like Notch, STAT, JAK. Although drug therapy dialysis technology continue advance, survival time quality life patients still face challenges. Therefore, early diagnosis prevention CKD-related CVC, reducing its rate, improving patients’ have become urgent issues field public In review, we try summarize state-of-the-art understanding progression hope that it will help treatment CKD.

Language: Английский

Citations

1
The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease DOI Creative Commons
Yibing Wang, Tong Li, Fengyu Wang

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 21(2), P. 632 - 657

Published: Dec. 31, 2024

Aging is a complex biological process that involves the gradual decline of cellular, tissue, and organ functions.In kidney, aging manifests as tubular atrophy, glomerulosclerosis, progressive renal function decline.The critical role senescence-associated macrophage in diseases, particularly kidney increasingly recognized.During this process, macrophages exhibit range pro-damage response to senescent tissues cells, while themselves also significantly influences disease progression, creating bidirectional regulatory between macrophages.To explore mechanism, review will elucidate origin, characteristic, phenotype, secretory phenotype (SASP), extracellular vesicles from senescence cell-engulfment suppression (SCES), context disease.Additionally, it discuss characteristics macrophage, such common markers, changes autophagy, metabolism, gene regulation, phagocytosis, antigen presentation, exosome secretion, along with their physiological pathological impacts on tissue cells.Furthermore, exploring therapies drugs modulate or eliminate cells may help slow progression damage.

Language: Английский

Citations

1