Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 11, 2024
Ferroptosis,
an
iron-ion-dependent
process
of
lipid
peroxidation,
damages
the
plasma
membrane,
leading
to
non-programmed
cell
death.
Osteoarthritis
(OA),
a
prevalent
chronic
degenerative
joint
disease
among
middle-aged
and
older
adults,
is
characterized
by
chondrocyte
damage
or
loss.
Emerging
evidence
indicates
that
ferroptosis
plays
role
in
OA
development.
However,
most
research
has
concentrated
on
regulation
involving
typical
iron
ions,
potentially
neglecting
significance
elevated
copper
ions
both
serum
fluid
patients
with
OA.
This
review
aims
fill
this
gap
systematically
examining
interplay
between
metabolism,
oxidative
stress,
ferroptosis,
copper-associated
death
It
will
provide
comprehensive
overview
ions'
regulating
their
dual
approach
seeks
offer
new
insights
for
further
research,
prevention,
treatment
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 11, 2024
Ferroptosis,
an
iron-ion-dependent
process
of
lipid
peroxidation,
damages
the
plasma
membrane,
leading
to
non-programmed
cell
death.
Osteoarthritis
(OA),
a
prevalent
chronic
degenerative
joint
disease
among
middle-aged
and
older
adults,
is
characterized
by
chondrocyte
damage
or
loss.
Emerging
evidence
indicates
that
ferroptosis
plays
role
in
OA
development.
However,
most
research
has
concentrated
on
regulation
involving
typical
iron
ions,
potentially
neglecting
significance
elevated
copper
ions
both
serum
fluid
patients
with
OA.
This
review
aims
fill
this
gap
systematically
examining
interplay
between
metabolism,
oxidative
stress,
ferroptosis,
copper-associated
death
It
will
provide
comprehensive
overview
ions'
regulating
their
dual
approach
seeks
offer
new
insights
for
further
research,
prevention,
treatment
