Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 15(5), P. 2230 - 2251
Published: Oct. 1, 2024
The prognosis for liver cancer (LC) is dismal. Researchers recently discovered cuproptosis, a novel form of controlled cell death whose expression in LC and are unclear. This study reveals gene signature to predict prognosis.
Language: Английский
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Abstract Disturbances in intracellular copper (Cu) homeostasis can trigger cuproptosis, a new form of cell death, which, when combined with photothermal therapy (PTT), offers promising solution to the persistent challenges colorectal cancer (CRC) treatment. In this study, “three‐level nanoparticle rocket” strategy is developed by engineering Cu 5.4 O, multifunctional Cu‐based nanoenzyme that and has electron transfer properties antioxidant efficiency. O effectively remodels inflammatory environment scavenging reactive oxygen species, thereby overcoming traditional limitations PTT. Concurrently, releases substantial amounts + into malignant cells, disrupting homeostasis, inducing ultimately inhibiting tumor progression. vivo vitro experiments demonstrate operates through multiple successive interlocking stages significantly eradicate tumors, prevent relapse, prolong survival. This study provides profound insights synergistic effects PTT, regulation, cuproptosis within complex microenvironment, presenting innovative approaches for future CRC therapy.
Language: Английский
Citations
0
Journal of Cancer, Journal Year: 2025, Volume and Issue: 16(4), P. 1264 - 1280
Published: Jan. 13, 2025
Background: Cuproptosis, a form of copper-mediated programmed cell death, has recently garnered significant attention. However, the mechanisms by which CRGs affect progression CRC remain unclear. Methods: Bioinformatics approaches were employed to analyze transcriptomic datasets and clinical data from 630 patients, focusing on copy number variations, prognostic implications, immune infiltration characteristics associated with CRGs. Key CRG-related genes impacting prognosis identified using LASSO Cox regression methods. A model incorporating various molecular markers parameters was constructed training cohort validated separate validation cohort. This used explore indicators, infiltration, tumor microenvironment in patients. Additionally, single-cell analysis performed investigate biological roles critical genes, expression patterns these assessed via qRT-PCR WB. Results: scoring established based three pivotal prognosis. model, an independent indicator, outperformed traditional clinicopathological features predicting patient outcomes. Kaplan-Meier survival curves demonstrated superior outcomes for individuals low-risk group compared those high-risk group. Model stability reliability confirmed through ROC univariate multivariate analyses. Further revealed correlations between scores presence M0 macrophages memory CD4+ T cells. Differences CDKN2A, PLCB4, NXPE4 across tissues cells characterized WB, IHC qRT-PCR. Conclusion: study not only highlights diverse omics profiles but also introduces novel accurate forecasting.
Language: Английский
Citations
0
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110324 - 110324
Published: Feb. 1, 2025
Language: Английский
Citations
0
Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 99 - 99
Published: Feb. 5, 2025
Tuberculosis (TB) caused by Mycobacterium tuberculosis (M.tb) remains a global health crisis, with over 10 million people affected annually. Despite advancements in treatment, M.tb has developed mechanisms to evade host immune responses, complicating efforts eradicate the disease. Two emerging cell death pathways, ferroptosis and cuproptosis, have been linked TB pathogenesis. Ferroptosis, an iron-dependent form of death, is driven lipid peroxidation reactive oxygen species (ROS) accumulation. This process can limit replication depleting intracellular iron inducing macrophage necrosis. However, excessive may lead tissue damage aid bacterial dissemination. Cuproptosis, triggered copper accumulation, disrupts mitochondrial metabolism, leading protein aggregation death. exploits both metabolism survive within macrophages, manipulating these processes resist oxidative stress responses. review examines roles cuproptosis TB, discussing how manipulates pathways for survival. While therapeutic strategies targeting processes, such as inducers (Erastin, RSL3) inhibitors (Ferrostatin-1) ionophores (Disulfiram, Elesclomol) chelators, show promise, limited understanding potential off-target effects significant challenge. Further exploration provide insights into development targeted therapies aimed at controlling infection while minimizing damage. By elucidating complex interactions between ferroptosis, future could better address resistance improve clinical outcomes.
Language: Английский
Citations
0
World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(3)
Published: Feb. 13, 2025
There is still no effective treatment for pancreatic cancer, one of the deadliest malignancies among gastrointestinal diseases. Jiang et al demonstrated presence senescent cancer-associated fibroblasts (CAFs) in cancer tissues, supporting use CAFs as potential anti-cancer targets. The study indicated that a natural plant-derived compound resveratrol can reverse CAF phenotype and decrease growth, migration, invasiveness cells. Notably, might be involved regulating epithelial-to-mesenchymal transition tumor microenvironment. This editorial shares insights on future investigation signaling cells microenvironment, discusses resveratrol-based perspectives.
Language: Английский
Citations
0
BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 31, 2025
Sepsis-induced myocardial dysfunction (SIMD) is a serious sepsis complication with high mortality, yet current diagnostic and therapeutic approaches remain limited. The lack of early, specific biomarkers effective treatments necessitates exploration novel mechanisms. Recently, cuproptosis has been implicated in various diseases, but its role SIMD unclear. This study aimed to identify cuproptosis-related potential agents, supported by animal model validation. Four GEO datasets (GSE79962, GSE267388, GSE229925, GSE229298) were analyzed using Limma WGCNA overlapping genes from differentially expressed (DEGs), DEGs (DE-CRGs), module-associated genes. Gene Set Enrichment Analysis (GSEA) single-sample GSEA (ssGSEA) performed assess biological functions immune cell infiltration, respectively. ceRNA transcription factor networks constructed explore gene regulatory mechanisms, while consensus clustering was employed define subtypes. Diagnostic selected through SVM–RFE, LASSO, random forest models. Additionally, gene-targeting agents predicted drug-gene interaction analysis. findings validated models qPCR immunohistochemical analysis confirm expression. PDHB DLAT emerged as key biomarkers. indicated upregulation oxidative phosphorylation downregulation chemokine signaling. ssGSEA revealed negative correlations several types. A network (51 nodes, 56 edges) constructed. Machine learning identified PDHB, NDUFA9, TIMMDC1 genes, showing accuracy (AUC = 0.995 GSE79962; AUC 0.960, 0.864, 0.984 external datasets). Using the DSigDB database, we six drugs that exhibit significant binding activity PDHB. immunohistochemistry confirmed reduced expression identifies biomarkers, addressing gaps unveiling molecular insights for early intervention targeted treatment. Not applicable.
Language: Английский
Citations
0
Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 15(5), P. 2230 - 2251
Published: Oct. 1, 2024
The prognosis for liver cancer (LC) is dismal. Researchers recently discovered cuproptosis, a novel form of controlled cell death whose expression in LC and are unclear. This study reveals gene signature to predict prognosis.
Language: Английский
Citations
1