Cellular crosstalk in the bone marrow niche DOI Creative Commons

Zeqi Huang,

Zoya Iqbal,

Zhe Zhao

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 3, 2024

The bone marrow niche is a special microenvironment that comprises elements, including hematopoietic stem cells, osteoblasts, and endothelial helps maintain their characteristic functions. Here, we elaborate on the crosstalk between various cellular components, other cells in niche. We further explain mechanism of preserving equilibrium niche, which crucial for directional regulation reconstruction repair. Additionally, elucidate intercommunication among osteocytes, osteoblast maturation activation by lymphocytes, deficiency megakaryocytes can markedly impair formation, interaction macrophages mesenchymal Finally, discussed new immunotherapies tumors BM In this review, aimed to provide candid overview highlight concepts underlying unknown mechanisms hematopoiesis reconstruction. Thus, review may more comprehensive understanding role these improving function help identify therapeutic potential different diseases future.

Language: Английский

RSK1 and RSK2 as therapeutic targets: an up-to-date snapshot of emerging data DOI Creative Commons

Ashley N. Spirrison,

Deborah A. Lannigan

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Dec. 4, 2024

Introduction The four members of the p90 ribosomal S6 kinase (RSK) family are serine/threonine protein kinases, which phosphorylated and activated by ERK1/2. RSK1/2/3 further PDK1. Receiving inputs from two major signaling pathways places RSK as a key node in numerous pathologies. A plethora RSK1/2 substrates have been identified, majority cases causative roles these play pathology unknown.

Language: Английский

Citations

4
Cellular crosstalk in the bone marrow niche DOI Creative Commons

Zeqi Huang,

Zoya Iqbal,

Zhe Zhao

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 3, 2024

The bone marrow niche is a special microenvironment that comprises elements, including hematopoietic stem cells, osteoblasts, and endothelial helps maintain their characteristic functions. Here, we elaborate on the crosstalk between various cellular components, other cells in niche. We further explain mechanism of preserving equilibrium niche, which crucial for directional regulation reconstruction repair. Additionally, elucidate intercommunication among osteocytes, osteoblast maturation activation by lymphocytes, deficiency megakaryocytes can markedly impair formation, interaction macrophages mesenchymal Finally, discussed new immunotherapies tumors BM In this review, aimed to provide candid overview highlight concepts underlying unknown mechanisms hematopoiesis reconstruction. Thus, review may more comprehensive understanding role these improving function help identify therapeutic potential different diseases future.

Language: Английский

Citations

1