A multidimensional pan‐cancer analysis of NDUFA4L2 and verification of the oncogenic value in colon cancer DOI Open Access
Jianing Yi,

Wenjie Gao,

Cheng Wu

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(1)

Published: Jan. 10, 2025

Abstract NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4‐like 2 (NDUFA4L2) protein is located in the mitochondria and can regulate cell proliferation. Some studies have shown that high NDUFA4L2 expression linked with poor prognosis cancer progression various patients cancers. However, correlation between pan‐cancer unknown. In this study, we used databases investigated variation of many cancers detail to determine its diagnostic prognostic values. We also validated oncogenic capability colon by experiments or tissue microarray. most cancers, levels are upregulated, a level associated OS. addition, results showed 10 proteins 30 genes were correlated . An additional analysis demonstrated these exhibited either negative positive correlations specific pathways. Moreover, discovered was related tumor stemness, MSI, TMB, immune infiltration ROS production. Our show affects development mitochondrial function lines. Finally, identified sensitive anticancer drugs. study suggest could serve as therapeutic biomarker for cancer, including cancer.

Language: Английский

A multidimensional pan‐cancer analysis of NDUFA4L2 and verification of the oncogenic value in colon cancer DOI Open Access
Jianing Yi,

Wenjie Gao,

Cheng Wu

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(1)

Published: Jan. 10, 2025

Abstract NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4‐like 2 (NDUFA4L2) protein is located in the mitochondria and can regulate cell proliferation. Some studies have shown that high NDUFA4L2 expression linked with poor prognosis cancer progression various patients cancers. However, correlation between pan‐cancer unknown. In this study, we used databases investigated variation of many cancers detail to determine its diagnostic prognostic values. We also validated oncogenic capability colon by experiments or tissue microarray. most cancers, levels are upregulated, a level associated OS. addition, results showed 10 proteins 30 genes were correlated . An additional analysis demonstrated these exhibited either negative positive correlations specific pathways. Moreover, discovered was related tumor stemness, MSI, TMB, immune infiltration ROS production. Our show affects development mitochondrial function lines. Finally, identified sensitive anticancer drugs. study suggest could serve as therapeutic biomarker for cancer, including cancer.

Language: Английский

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