Ultrasound-responsive nanobubble-mediated sonodynamic therapy sensitizes disulfidptosis in the treatment of liver hepatocellular carcinoma DOI Creative Commons
Yichi Chen, Xin Lin, Jiayue Qiu

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: 118, P. 107368 - 107368

Published: April 23, 2025

Disulfidptosis, a newly identified regulated cell death, is linked to tumor progression, particularly in cancers with elevated SLC7A11 expression. This study investigates expression liver hepatocellular carcinoma (LIHC) and evaluates the therapeutic potential of ICG@C3F8-KL nanobubbles (NBs) combined sonodynamic therapy (SDT) for inducing disulfidptosis. Bioinformatics analysis TCGA datasets revealed upregulation LIHC tissues. The synthesized NBs exhibited mean diameter 156.46 nm stable properties, high encapsulation efficiencies 51.32 % ± 0.7 KL 80.15 0.21 ICG. In vitro, NBs, under ultrasound, generated reactive oxygen species (ROS), enhancing cytotoxicity HepG2 cells an IC50 lower than alone. These also inhibited migration colony formation, suggesting disulfidptosis induction via altered glucose uptake NADP+/NADPH ratio, as well F-actin contraction. vivo, accumulated tissues suppressed growth without significant toxicity. Unsupervised clustering disulfidptosis-related genes cohort subtypes distinct prognoses, predictive model based on five key was developed. conclusion, effectively induce disulfidptosis, offering promising strategy treatment, personalized informed by disulfide-associated gene signatures.

Language: Английский

Targeting novel regulated cell death: disulfidptosis in cancer immunotherapy with immune checkpoint inhibitors DOI Creative Commons
Fei Du, Guojun Wang, Qian Dai

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 26, 2025

Abstract The battle against cancer has evolved over centuries, from the early stages of surgical resection to contemporary treatments including chemotherapy, radiation, targeted therapies, and immunotherapies. Despite significant advances in treatment recent decades, these therapies remain limited by various challenges. Immune checkpoint inhibitors (ICIs), a cornerstone tumor immunotherapy, have emerged as one most promising advancements treatment. Although ICIs, such CTLA-4 PD-1/PD-L1 inhibitors, demonstrated clinical efficacy, their therapeutic impact remains suboptimal due patient-specific variability immune resistance. Cell death is fundamental process for maintaining tissue homeostasis function. Recent research highlights that combination induced regulatory cell (RCD) ICIs can substantially enhance anti-tumor responses across multiple types. In cells exhibiting high levels recombinant solute carrier family 7 member 11 (SLC7A11) protein, glucose deprivation triggers programmed (PCD) pathway characterized disulfide bond formation REDOX (reduction-oxidation) reactions, termed “disulfidptosis.” Studies suggest disulfidptosis plays critical role efficacy SLC7A11 cancers. Therefore, investigate potential synergy between this study will explore mechanisms both processes progression, with goal enhancing response targeting intracellular pathway.

Language: Английский

Citations

0
Disulfidptosis: a new target for central nervous system disease therapy DOI Creative Commons
Jing Chang,

Danhong Liu,

Yunbei Xiao

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: March 5, 2025

Disulfidptosis is a pathologic process that occurs under conditions of NADPH deficiency and excess disulfide bonds in cells express high levels SLC7A11. This caused by glucose deprivation-induced stress was first described cancer researchers. Oxidative hypothesized mechanism underlying diseases the central nervous system (CNS), specific type oxidative stress. Proteins linked to disulfidptosis metabolic pathways involved are significantly associated with CNS (neurodegenerative disease, neurogliomas ischemic stroke). However, responsible for this correlation remains unknown. review provides comprehensive overview current knowledge regarding origin elements, genetic factors, signaling proteins pathogenesis disulfidptosis. It demonstrates disruption thiometabolism play critical roles diseases, which potential role We also summarize disulfidptosis-related drugs highlight therapeutic strategies treating diseases. Additionally, paper suggests testable hypothesis might be promising target

Language: Английский

Citations

0
Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder DOI
Yutong Liu, Yaqi Sun,

Anjie Chen

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 369, P. 123531 - 123531

Published: March 5, 2025

Language: Английский

Citations

0
Identification of Diagnostic Biomarkers and Therapeutic Targets for Abdominal Aortic Aneurysms Based on Disulfidptosis Mechanism DOI Creative Commons

Ronggui Chen,

Junzhu Shi, Yipeng Zhang

et al.

Current Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Identification of disulfidptosis in esophageal squamous cell carcinoma based on single-cell and bulk RNA-seq data to predict prognosis and treatment response DOI Creative Commons
Xiaodan Zhang, Jianting Du, Xiao Lin

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Purpose Our study aims to identify the molecular subtypes of genes associated with disulfidptosis in esophageal squamous cell carcinoma(ESCC), develop a prognostic model, and potential therapeutic targets. Methods Based on GSE53625 expression profile data, we identified significant survival differences through consensus cluster analysis. Subsequently, univariate Cox, multivariate LASSO-Cox regression analysis were used establish risk stratification models. The transcriptome data TCGA-ESCC cohort GSE160269 single-cell sequencing dataset integrated verify biological significance further analyze heterogeneity tumor immune microenvironment, explore intercellular communication network, screen targeted drugs, providing theoretical basis for subsequent translational research. Results We two distinct patterns overall survival. Then, constructed signature disulfidptosis, results showed patients high score had worse prognosis. Univariate Cox demonstrated that was an independent factor validated validation set. subgroups differed proportion infiltration related signaling pathways ESCC. exploration immunotherapy confirmed our also certain predictive power immunotherapy. Drug screening suggested AZD8186 JQ1 as therapies high-score patients. Conclusion This provides new ESCC, explores targets, support personalized treatment.

Language: Английский

Citations

0
Ultrasound-responsive nanobubble-mediated sonodynamic therapy sensitizes disulfidptosis in the treatment of liver hepatocellular carcinoma DOI Creative Commons
Yichi Chen, Xin Lin, Jiayue Qiu

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: 118, P. 107368 - 107368

Published: April 23, 2025

Disulfidptosis, a newly identified regulated cell death, is linked to tumor progression, particularly in cancers with elevated SLC7A11 expression. This study investigates expression liver hepatocellular carcinoma (LIHC) and evaluates the therapeutic potential of ICG@C3F8-KL nanobubbles (NBs) combined sonodynamic therapy (SDT) for inducing disulfidptosis. Bioinformatics analysis TCGA datasets revealed upregulation LIHC tissues. The synthesized NBs exhibited mean diameter 156.46 nm stable properties, high encapsulation efficiencies 51.32 % ± 0.7 KL 80.15 0.21 ICG. In vitro, NBs, under ultrasound, generated reactive oxygen species (ROS), enhancing cytotoxicity HepG2 cells an IC50 lower than alone. These also inhibited migration colony formation, suggesting disulfidptosis induction via altered glucose uptake NADP+/NADPH ratio, as well F-actin contraction. vivo, accumulated tissues suppressed growth without significant toxicity. Unsupervised clustering disulfidptosis-related genes cohort subtypes distinct prognoses, predictive model based on five key was developed. conclusion, effectively induce disulfidptosis, offering promising strategy treatment, personalized informed by disulfide-associated gene signatures.

Language: Английский

Citations

0