Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114985 - 114985

Published: June 11, 2023

The gut microbiota is indispensable for maintaining host health by enhancing the host's digestive capacity, safeguarding intestinal epithelial barrier, and preventing pathogen invasion. Additionally, exhibits a bidirectional interaction with immune system promotes of to mature. Dysbiosis microbiota, primarily caused factors such as genetic susceptibility, age, BMI, diet, drug abuse, significant contributor inflammatory diseases. However, mechanisms underlying diseases resulting from dysbiosis lack systematic categorization. In this study, we summarize normal physiological functions symbiotic in healthy state demonstrate that when occurs due various external factors, are lost, leading pathological damage lining, metabolic disorders, barrier damage. This, turn, triggers disorders eventually causes systems. These discoveries provide fresh perspectives on how diagnose treat unrecognized variables might affect link between illnesses need further studies extensive basic clinical research will still be required investigate relationship future.

Language: Английский

---

The role of tumor-associated macrophages in tumor immune evasion

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(5)

Published: May 7, 2024

Abstract Background Tumor growth is closely linked to the activities of various cells in tumor microenvironment (TME), particularly immune cells. During progression, circulating monocytes and macrophages are recruited, altering TME accelerating growth. These adjust their functions response signals from stromal Tumor-associated (TAMs), similar M2 macrophages, key regulators TME. Methods We review origins, characteristics, TAMs within This analysis includes mechanisms through which facilitate evasion promote metastasis. Additionally, we explore potential therapeutic strategies that target TAMs. Results instrumental mediating malignant behaviors. They release cytokines inhibit effector attract additional immunosuppressive primarily T cells, inducing exhaustion directly, influencing activity indirectly cellular interactions, or suppressing checkpoints. directly involved proliferation, angiogenesis, invasion, Summary Developing innovative tumor-targeted therapies immunotherapeutic currently a promising focus oncology. Given pivotal role evasion, several approaches have been devised them. include leveraging epigenetics, metabolic reprogramming, engineering repolarize TAMs, inhibiting recruitment activity, using as drug delivery vehicles. Although some these remain distant clinical application, believe future targeting will offer significant benefits cancer patients.

Language: Английский

---

Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 14, 2023

Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cell signals, TAMs exhibit unparalleled adaptability, aligning with dynamic milieu. Their roles span from promoting growth and angiogenesis modulating metastasis. While substantial research has explored fundamentals of TAMs, comprehending their adaptive behavior, leveraging it for novel treatments remains challenging. This review delves into TAM polarization, metabolic shifts, complex orchestration cytokines chemokines determining functions. We highlight complexities TAM-targeted focusing on adaptability potential variability in therapeutic outcomes. Moreover, we discuss synergy integrating TAM-focused strategies established treatments, such as chemotherapy, immunotherapy. Emphasis is laid pioneering methods like reprogramming immunotherapy adoption single-cell technologies precision intervention. synthesis seeks shed light TAMs’ multifaceted cancer, pinpointing prospective pathways transformative enhancing modalities oncology.

Language: Английский

---

SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration

British Journal of Cancer, Journal Year: 2024, Volume and Issue: 130(11), P. 1770 - 1782

Published: April 10, 2024

Language: Английский

---

Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 74, P. 101068 - 101068

Published: Feb. 13, 2024

Language: Английский

---

Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

Background and aims Immunologically hot tumors, characterized by an inflamed tumor microenvironment (TME), contrast significantly with immunologically cold tumors. The identification of these immune subtypes holds clinical significance, as tumors may exhibit improved prognoses heightened responsiveness to checkpoint blockade therapy. Nevertheless, yet there is no consensus regarding the clinically relevant definition hot/cold influence genes on formation remains poorly understood. Methods Data for 33 different types cancer were obtained from Cancer Genome Atlas database, their composition was assessed using CIBERSORT algorithm. Tumors categorized either or based distinct composition, ongoing response, overall survival. A customized immunogram created identify important immunological characteristics. Kyoto Encyclopedia Genes Genomes Hallmark pathway enrichment evaluated through gene set variation analysis. Additionally, hub that regulate identified, expression patterns analyzed single-cell RNA sequencing. Furthermore, drug sensitivity molecular docking analyses performed potential candidates capable transforming into For validation, a cohort patients diagnosed pancreatic adenocarcinoma examined multiplex immunohistochemistry. Results We able differentiate between in various (bladder urothelial carcinoma, adenocarcinoma, cervical squamous cell carcinoma) analyzing presence CD8+ T cells, activated natural killer M2-type macrophages, well cytolytic activity proliferation. Hub TME, including PDCD1 , CD276 NT5E discovered. increased its prognostic significance confirmed immunohistochemistry adenocarcinoma. Finally, dasatinib tozasertib identified converting Conclusion In this study, we developed framework discerning significant across types, further identifying several targets enhance anticancer treatment efficacy.

Language: Английский

---

Tumor associated macrophages in esophageal squamous carcinoma: Promising therapeutic implications

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115610 - 115610

Published: Sept. 30, 2023

Esophageal squamous carcinoma (ESCC) is a prevalent and highly lethal malignant tumor, with five-year survival rate of approximately 20 %. Tumor-associated macrophages (TAMs) are the most prominent immune cells in tumor microenvironment (TME), comprising over 50 % volume. TAMs can be polarized into two distinct phenotypes, M1-type M2-type, through interactions cancer cells. M2-type more abundant than TME, contributing to progression, such as cell construction an immunosuppressive environment. This review focuses on role ESCC, including their polarization, impact proliferation, angiogenesis, invasion, migration, therapy resistance, immunosuppression. In addition, we discuss potential targeting for clinical ESCC. A thorough comprehension molecular biology about essential development innovative therapeutic strategies treat

Language: Английский

---

A bibliometric and knowledge-map study on the treatment of hematological malignancies with CAR-T cells from 2012 to 2023

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: July 3, 2024

Recently, CAR-T cell therapy in hematological malignancies has received extensive attention. The objective of this study is to gain a comprehensive understanding the current research status, development trends, hotspots, and emerging topics pertaining cells treatment malignancies. Articles for from years 2012 2023 were obtained assessed Web Science Core Collection (WoSCC). A bibliometric approach was employed conduct scientific, comprehensive, quantitative analysis, as well visual particular domain. analysis conducted on corpus 3643 articles, which collaboratively authored by 72 countries various institutions. treating shows an increasing trend each year. Notably, identified institutions displaying highest level activity, journals with most citations output, authors who garnered frequency co-citations. Furthermore, successfully hotspots highlighted six within This exploration about 2023. findings will serve valuable reference guide researchers seeking delve deeper into field determine future direction their research.

Language: Английский

---

Targeting tumor‑associated macrophages: Critical players in tumor progression and therapeutic strategies (Review)

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(6)

Published: April 30, 2024

Tumor‑associated macrophages (TAMs) are essential components of the tumor microenvironment (TME) and display phenotypic heterogeneity plasticity associated with stimulation bioactive molecules within TME. TAMs predominantly exhibit tumor‑promoting phenotypes involved in progression, such as angiogenesis, metastasis, immunosuppression resistance to therapies. In addition, have potential regulate cytotoxic elimination phagocytosis cancer cells interact other immune engage innate adaptive systems. this context, targeting has been a popular area research therapy, comprehensive understanding complex role progression exploration macrophage‑based therapeutic approaches for future therapeutics against cancers. The present review provided updated overview function summarized recent advances TAM‑targeting strategies discussed obstacles perspectives therapies

Language: Английский

---

The Role of TAMs in the Regulation of Tumor Cell Resistance to Chemotherapy

Critical Reviews™ in Oncogenesis, Journal Year: 2024, Volume and Issue: 29(4), P. 97 - 125

Published: Jan. 1, 2024

Tumor-associated macrophages (TAMs) are the predominant cell infiltrate in immunosuppressive tumor microenvironment (TME). TAMs central to fostering pro-inflammatory conditions, growth, metastasis, and inhibiting therapy responses. Many cancer patients innately refractory chemotherapy or develop resistance following initial treatments. There is a clinical correlation between level of TME chemoresistance. Hence, pivotal role contributing chemoresistance has garnered significant attention toward targeting reverse this resistance. A prerequisite for such an approach requires thorough understanding various underlying mechanisms by which inhibit response chemotherapeutic drugs. Such include enhancing drug efflux, regulating metabolism detoxification, supporting stem (CSCs) resistance, promoting epithelial-mesenchymal transition (EMT), penetration its metabolism, stimulating angiogenesis, impacting inhibitory STAT3/NF-κB survival pathways, releasing specific cytokines including TGF-β IL-10. Accordingly, several strategies have been developed overcome TAM-modulated These novel therapies that aim deplete TAMs, repolarize them anti-tumor M1-like phenotype, block recruitment monocytes into TME. Current results from TAM-targeted treatments unimpressive; however, use combination appears promising with radiotherapy, chemotherapy, chemokine receptor inhibitors, immunotherapy, loaded nanoparticles. The limitations these discussed.

Language: Английский

---