Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: May 6, 2023
Abstract
Infantile
hemangioma
(IH)
is
the
most
prevalent
benign
vascular
tumor
in
infants,
with
distinct
disease
stages
and
durations.
Despite
fact
that
majority
of
IHs
can
regress
spontaneously,
a
small
percentage
cause
disfigurement
or
even
be
fatal.
The
mechanisms
underlying
development
IH
have
not
been
fully
elucidated.
Establishing
stable
reliable
models
provides
standardized
experimental
platform
for
elucidating
its
pathogenesis,
thereby
facilitating
new
drugs
identification
effective
treatments.
Common
include
cell
suspension
implantation
model,
viral
gene
transfer
tissue
block
transplantation
recent
three-dimensional
(3D)
microtumor
model.
This
article
summarizes
research
progress
clinical
utility
various
models,
as
well
benefits
drawbacks
each.
Researchers
should
select
based
on
their
individual
objectives
to
achieve
anticipated
objectives,
increasing
relevance
findings.
Cell & Bioscience,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 10, 2024
Abstract
Background
Neovascular
eye
disease
is
characterized
by
pathological
neovascularization,
with
clinical
manifestations
such
as
intraocular
exudation,
bleeding,
and
scar
formation,
ultimately
leading
to
blindness
in
millions
of
individuals
worldwide.
Pathologic
ocular
angiogenesis
often
occurs
common
fundus
diseases
including
proliferative
diabetic
retinopathy
(PDR),
age-related
macular
degeneration
(AMD),
prematurity
(ROP).
Anti-vascular
endothelial
growth
factor
(VEGF)
targets
the
core
pathology
angiogenesis.
Main
body
In
recent
years,
therapies
targeting
metabolism
prevent
have
also
rapidly
developed,
offering
assistance
patients
a
poor
prognosis
while
receiving
anti-VEGF
therapy
reducing
side
effects
associated
long-term
VEGF
usage.
Phosphofructo-2-kinase/fructose-2,6-bisphosphatase
3
(PFKFB3),
key
enzyme
targeted
metabolism,
has
been
shown
great
potential,
antiangiogenic
multiple
protective
treatment
neovascular
disease.
this
review,
we
summarize
mechanisms
types
diseases;
discuss
effect
potential
mechanism
PFKFB3,
related
inhibitors
PFKFB3;
look
forward
future
exploration
directions
therapeutic
prospects
PFKFB3
Conclusion
disease,
most
severely
debilitating
retinal
largely
incurable,
necessitating
new
methods.
possess
various
treating
With
development
several
drugs
their
gradual
entry
into
research,
PFKFB3-mediated
glycolysis
emerged
promising
approach
for
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2386 - 2386
Published: March 7, 2025
Angiogenesis,
the
process
by
which
new
blood
vessels
emerge
from
pre-existing
vasculature,
forms
fundamental
biological
basis
for
therapeutic
angiogenesis.
In
recent
years,
this
field
has
garnered
significant
attention,
particularly
in
context
of
understanding
mechanisms
angiogenesis
through
lens
glycometabolism.
The
potential
clinical
applications
research
have
been
widely
acknowledged
within
medical
community.
article,
role
and
principal
molecular
that
govern
it
are
first
delineated.
influence
glycometabolism
on
is
then
explored,
with
a
focus
glycolysis.
Finally,
based
regulation
presented,
offering
novel
perspectives
ongoing
applications.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: May 14, 2025
Hepatoblastoma
(HB),
the
most
common
pediatric
liver
malignancy,
is
characterized
by
aggressive
growth
and
metastasis
driven
complex
angiogenic
mechanisms.
This
review
elucidates
pivotal
role
of
angiogenesis
in
HB
progression,
emphasizing
metabolic
reprogramming,
tumor
microenvironment
(TME)
dynamics,
oncogenic
signalling
pathways.
The
Warburg
effect
cells
fosters
a
hypoxic
microenvironment,
stabilizing
hypoxia-inducible
factor-1α
(HIF-1α)
upregulating
vascular
endothelial
factor
(VEGF),
which
synergistically
enhances
angiogenesis.
Key
pathways
such
as
Wnt/β-catenin,
VEGF,
PI3K/AKT,
JAK2/STAT3
are
central
to
cell
proliferation,
migration,
maturation,
whereas
interactions
with
tumor-associated
macrophages
(TAMs)
pericytes
further
remodel
TME
support
neovascularization.
Long
noncoding
RNAs
glycolytic
enzymes
have
emerged
critical
regulators
angiogenesis,
linking
activity
expansion.
Anti-angiogenic
therapies,
including
VEGF
inhibitors
pathway-targeting
agents,
show
preclinical
promise
but
face
challenges
resistance
off-target
effects.
Future
directions
advocate
for
dual-target
strategies,
spatial
multiomics
technologies
map
metabolic–angiogenic
crosstalk,
personalized
approaches
leveraging
biomarkers
risk
stratification.
synthesis
underscores
need
interdisciplinary
collaboration
translate
mechanistic
insights
into
durable
ultimately
improving
outcomes
patients.
Discovery Medicine,
Journal Year:
2024,
Volume and Issue:
36(183), P. 678 - 678
Published: Jan. 1, 2024
An
imbalance
in
energy
metabolism
serves
as
a
causal
factor
for
type
2
diabetes
(T2D).
Although
metformin
has
been
known
to
ameliorate
the
overall
imbalance,
but
direct
correlation
between
and
central
carbon
(CCM)
not
thoroughly
investigated.
In
this
study,
we
employed
high-performance
ion
chromatography-tandem
mass
spectrometry
(HPIC-MS/MS)
technique
examine
alterations
significance
of
CCM
both
before
after
treatment
T2D.
Pediatric Health Medicine and Therapeutics,
Journal Year:
2024,
Volume and Issue:
Volume 15, P. 1 - 16
Published: Jan. 1, 2024
Abstract:
Hemangiomas
are
vascular
tumors
resulting
from
the
proliferation
of
endothelial-like
cells;
they
most
common
childhood
tumors,
affecting
approximately
5–
10%
newborns
and
infants.
Besides
hemangiomas,
which
definitely
benign
despite
their
overgrowth
potential,
there
other
like
hemangioendotheliomas,
may
display
intermediate
characteristics
between
hemangiomas
highly
malignant
angiosarcomas.
Standard
therapy
be
constricted
by
serious
adverse
effects,
high
cost,
or
traumatic
influence.
Diet
is
a
major
resource
for
health
preservation,
disease
prevention,
treatment.
The
therapeutic
property
edible
berries,
marine
products,
medicinal
plants
have
long
been
known
used
in
traditional
medicine;
plant-based
nutrition
can
prevent
development
progression
diseases
associated
with
extensive
neo-vascularization.
purpose
our
review
to
highlight
those
natural
treatments
that
hemangioma
tumor
patients
receive
future,
both
benefit
families.
We
performed
according
Preferred
Reporting
Items
Systematic
Reviews
Metanalysis
Statement.
Web
Science,
PubMed,
EMBASE
engines
study,
searched
association
naturopathic
treatment/plant
extract/plants
published
articles.
found
extracts
fruits
cost-effective
safe
as
well
forms
cancer.
In
any
case,
more
vitro
vivo
studies
needed
confirm
proposed
signaling
pathways
validate
improvement
parameters
after
products
administration.
era
molecularly
targeted
personalized
medicine
approaching
naturally
occurring
substances
very
useful
tools
treatment
prevention.
Plant
extract
strong
specificity
pertinence,
non-
toxic
few
side
become
an
emerging
cancer
Keywords:
abnormalities,
plants,
plant
extract,
Journal of Environmental Pathology Toxicology and Oncology,
Journal Year:
2024,
Volume and Issue:
43(4), P. 53 - 64
Published: Jan. 1, 2024
Ovarian
cancer
is
one
of
the
most
common
malignant
tumors
in
female
reproductive
organs.
Its
incidence
rate
second
only
to
uterine
body
and
cervical
cancer,
posing
a
serious
threat
women's
health.
Herein,
we
explored
that
PFKFB3
progression
ovarian
its
underlying
mechanism.
All
serum
samples
from
were
collected
by
our
hospital.
mRNA
expressions
patients
with
cell
lines
up-regulated.
protein
cells
induced.
high
PFKFB3expression
had
lower
survival
rate.
The
PFKFB3gene
promoted
proliferation
EDU
cells,
increased
metastasis
cancer.
Si-PFKFB3
reduced
decreased
gene
up-regulation
caspase-3/9
activity
levels
also
Warburg
effect
NLRP3-induced
pyroptosis
suppressed
NLRP3
expression.
was
target
spot
for
on
Taken
together,
conclude
axis
reduce
increase
provide
molecular
insight
into
mechanisms
which
regulates
