Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 31, 2024
Language: Английский
Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(9), P. 1375 - 1385
Published: May 27, 2024
Language: Английский
Citations
37
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129633 - 129633
Published: Jan. 21, 2024
Language: Английский
Citations
10
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 4089 - 4116
Published: Sept. 1, 2024
With the continuous refinement of therapeutic measures, survival rate tumor patients has been improving year by year, while cardiovascular complications related to cancer therapy have become increasingly prominent. Exploring mechanism and prevention strategy therapy-related toxicity (CTR-CVT) remains one research hotspots in field Cardio-Oncology recent years. Cardiotoxicity anticancer drugs involves heart failure, myocarditis, hypertension, arrhythmias vascular toxicity, mechanistically endothelial dysfunction, ferroptosis, mitochondrial dysfunction oxidative stress. To address cardiotoxicity induced different drugs, various measures put place, such as reducing accumulation shifting with less cardiotoxicity, using cardioprotective early detection. Due very limited treatments available ameliorate drugs-induced a few innovations are being shifted from animal studies human studies. Examples include transplantation. Mitochondrial transplantation proven be effective vivo vitro experiments. Several demonstrated that intercellular transfer can doxorubicin(DOX)-induced laying foundation for innovative therapies cardiotoxicity. In this review, we will discuss current status terms pathogenesis treatment, focus on transplantation, hope review bring some inspiration you.
Language: Английский
Citations
10
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 7, 2025
To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), most prevalent pathological condition in human medicine, is induced by coronary artery narrowing, or occlusion, leading to bulk necrotic changes and fibrosis within myocardium. Data associated with pro-angiogenic activity mitochondria have not completely elucidated terms cardiac tissue regeneration. Here, we aimed highlight recent studies advantages related application mass How which mechanisms, can reduce aberrant myocardial remodeling via different pathways such as angiogenesis de novo blood formation was discussed detail. We hope that data from current review article help us understand molecular cellular mechanisms transplanted exert their properties
Language: Английский
Citations
1
Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(3), P. 617 - 636
Published: Jan. 24, 2024
Language: Английский
Citations
6
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Aging is an inevitable and complex biological process involving multi-factorial mechanisms. Mitochondrial dysfunction a critical factor in the aging process, characterized by decline mitochondrial quality activity, leading to aging-related diseases. Therefore, mitochondria have become attractive target anti-aging therapies. Several senolytic drugs targeting antioxidant agents been used research past few years. However, these strategies may cause adverse effects with long-term medication. In this extensive review, we propose "mitochondrial transplantation," which transfers healthy from donor cells recipient replace damaged or dysfunctional mitochondria, as new alternative strategy for treating aging-associated introduce contemporary landscape of transplantation, then discuss intensely successful applications transplantation therapy diseases such neurodegenerative diseases, cardiovascular aging, reproductive highlighting its translational potential. Finally, summarize prospect challenges opportunities faces therapy.
Language: Английский
Citations
5
Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111590 - 111590
Published: Jan. 10, 2025
Language: Английский
Citations
0
Rare Disease and Orphan Drugs Journal, Journal Year: 2025, Volume and Issue: 5(2)
Published: March 26, 2025
Duchenne muscular dystrophy (DMD) is a severe and progressively debilitating X-linked recessive disorder caused by mutations in the DMD gene, which encodes dystrophin protein. This deficiency results progressive degeneration of both skeletal cardiac muscles. Currently, there no definitive cure for DMD, treatment primarily aims to slow disease progression manage symptoms. With widespread application respiratory support measures, cardiomyopathy has emerged as primary contributor morbidity mortality among patients at present. There an acute pressing need develop highly effective therapeutic strategies treating prevent onset heart failure. Various hypotheses have been proposed explain underlying mechanisms, including elevated levels inflammatory cytokines, dysregulated HDAC activity, disruptions ion balance, mitochondrial dysfunction, also considered potentially significant contributor. review article provide comprehensive overview various animal human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) models on cardiomyopathy. It provides summary current advancements ongoing efforts DMD-related cardiomyopathy, with focus innovative modalities, such mitochondria transplantation or targeting homeostasis. underscores dynamic evolving nature research dedicated developing treatments
Language: Английский
Citations
0
Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 4, 2025
Language: Английский
Citations
0
ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Mitochondria are vital for energy production, metabolic regulation, and cellular signaling. Their dysfunction is strongly implicated in neurological, cardiovascular, muscular degenerative diseases, where deficits oxidative stress accelerate disease progression. Platelet extracellular vesicles (PEVs), once called "platelet dust", have emerged as promising agents mitigating mitochondrial dysfunction. Like other (EVs), PEVs carry diverse molecular cargo surface markers processes therapeutic efficacy. Notably, they may possibly contain intact or partially functional components, making them tentatively attractive targeting damage. Although direct research on PEVs-mediated rescue remains limited, current evidence suggests that can modulate diseases associated with potentially enhance health. This review explores the potential of neurodegenerative cardiovascular disorders, highlighting their role restoring By examining recent advancements research, we aim to shed light novel strategies utilizing agents. Our goal underscore importance further fundamental applied into PEVs-based interventions, innovative tools combating a wide range linked
Language: Английский
Citations
0