Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Dec. 24, 2024
Background
Non-alcoholic
fatty
liver
disease
(NAFLD)
and
chronic
kidney
(CKD)
are
both
closely
related
to
dyslipidemia.
However,
the
relationship
between
dyslipidemia
in
patients
with
NAFLD
CKD
is
not
yet
clear.
The
non-high-density
lipoprotein
cholesterol
high-density
ratio
(NHHR)
an
innovative
comprehensive
lipid
index.
purpose
of
this
study
was
investigate
correlation
NHHR
risk
or
without
fibrosis.
Methods
This
used
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2017
2020
for
analysis,
including
a
total
4,041
subjects
diagnosed
NAFLD.
Among
subjects,
3,315
individuals
fibrosis
726
Weighted
multivariate
linear
regression,
weighted
logistic
restricted
cubic
spline
(RCS)
curves,
subgroup
analysis
were
evaluate
Results
Our
findings
indicate
that
fibrosis,
highest
tertile
NHHR,
as
compared
lowest
tertile,
inversely
glomerular
filtration
rate
(eGFR)
(
β
:
−2.14,
95%
CI:
−3.97,
−0.32,
p
<
0.05)
positively
(OR:
1.67,
1.12,
2.49,
0.05).
No
significant
associations
observed
eGFR,
urinary
albumin
creatinine
(ACR)
RCS
revealed
ACR,
while
U-shaped
Conclusion
In
non-fibrotic
NAFLD,
significantly
elevated
associated
increased
shows
CKD.
fibrotic
LD,
underscore
practical
utility
biomarker
early
stratification
British Journal Of Nutrition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 31
Published: Nov. 4, 2024
Abstract
To
investigate
the
associations
between
dietary
patterns
and
biological
aging,
identify
most
recommended
pattern
for
coping
with
aging
explore
potential
mediating
role
of
gut
microbiota
in
less-developed
ethnic
minority
regions
(LEMRs).
This
prospective
cohort
study
included
8288
participants
aged
30-79
years
from
China
Multi-Ethnic
Cohort
(CMEC).
Anthropometric
measurements
clinical
biomarkers
were
utilized
to
construct
age
based
on
Klemera
Doubal’s
method
(KDM-BA)
KDM-BA
acceleration
(KDM-AA).
Dietary
information
was
obtained
through
baseline
food
frequency
questionnaire
(FFQ).
Six
constructed:
plant-based
diet
index
(PDI),
healthful
(hPDI),
unhealthful
(uPDI),
healthy
score
(HDS),
Approaches
Stop
Hypertension
(DASH),
alternative
Mediterranean
diets
(aMED).
Follow-up
adjusted
analysis
employed
assess
KDM-AA.
Additionally,
quantile
G-computation
evaluate
significant
beneficial
harmful
groups.
In
subsample
764
data
16S
rRNA
gene
sequencing,
we
used
causal
mediation
model
The
results
showed
that
all
associated
Transitioning
non-compliance
compliance,
DASH
exhibited
strongest
negative
association
KDM-AA
[
β
=
-0.91,
95%CI
(-1.19,
-0.63)].
component
analyses
revealed
tea
soybean
products
groups,
while
salt,
preserved
vegetables,
red
processed
meats
identified
as
major
analysis,
decreased
abundance
Synergistetes
phylum
Pyramidobacter
genus
possibly
mediated
(5.61%-9.19%).
Overall,
patterns,
especially
DASH,
are
negatively
LEMRs.
may
mediate
aging.
Developing
appropriate
strategies
promote
Frontiers in Public Health,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 1, 2024
Purpose
Limited
investigation
is
available
on
the
correlation
between
environmental
phenols’
exposure
and
estimated
glomerular
filtration
rate
(eGFR).
Our
target
established
a
robust
explainable
machine
learning
(ML)
model
that
associates
with
eGFR.
Methods
datasets
for
constructing
associations
eGFR
were
collected
from
National
Health
Nutrition
Examination
Survey
(NHANES,
2013–2016).
Five
ML
models
contained
fine-tuned
to
regression
by
exposure.
Regression
evaluation
metrics
used
extract
limitation
of
models.
The
most
effective
was
then
utilized
regression,
interpretation
its
features
carried
out
using
shapley
additive
explanations
(SHAP)
game
theory
python
package
represent
model’s
capacity.
Results
study
identified
top-performing
random
forest
(RF)
regressor
mean
absolute
error
0.621
coefficient
determination
0.998
among
3,371
participants.
Six
phenols
in
linear
revealed
concentrations
triclosan
(TCS)
bisphenol
S
(BPS)
urine
positively
correlated
eGFR,
coefficients
β
=
0.010
(
p
0.026)
0.007
0.004)
respectively.
SHAP
values
indicate
BPS
(1.38),
F
(BPF)
(0.97),
2,5-dichlorophenol
(0.87),
TCS
(0.78),
BP3
(0.60),
A
(BPA)
(0.59)
2,4-dichlorophenol
(0.47)
urinary
contributed
model.
Conclusion
RF
efficient
identifying
United
States
NHANES
2013–2016
findings
BPA,
BPF,
are
inversely
associated
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Aug. 9, 2024
Objective
This
investigation
aims
to
elucidate
the
correlations
between
dietary
intakes
of
vitamin
E,
B6,
and
niacin
incidence
cataracts,
utilizing
comprehensive
NHANES
2005–2008
dataset
affirm
prophylactic
roles
these
nutrients
against
cataract
formation.
Methods
Using
data
from
cycles,
this
analysis
concentrated
on
7,247
subjects
after
exclusion
based
incomplete
or
data.
The
identification
cataracts
was
determined
through
participants’
self-reported
ophthalmic
surgical
history.
Nutritional
intake
gauged
using
automated
multiple
pass
method,
were
analyzed
logistic
quantile
regression
analyses
investigate
relationship
consumption
prevalence.
Results
Our
identified
significant
inverse
associations
vitamins
risk
development.
Specifically,
higher
B6
(OR
=
0.85,
95%
CI
0.76–0.96,
p
0.0073)
0.98,
0.97–1.00,
0.0067)
in
top
quartile
significantly
associated
with
a
reduced
likelihood
occurrence.
Vitamin
E
showed
consistent
reduction
across
different
levels
0.96,
0.94–0.99,
0.0087),
demonstrating
nonlinear
correlation.
Conclusion
outcomes
indicate
that
elevated
niacin,
conjunction
regular
intake,
may
have
potential
delay
prevent
genesis.
These
results
suggest
novel
nutritional
strategy
for
prevention
management,
advocating
focused
nutrient
supplementation
could
be
instrumental
preserving
eye
health
reducing
cataracts.
Further
research
is
recommended
validate
findings
establish
optimal
dosages
maximum
benefit.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Dec. 24, 2024
Background
Non-alcoholic
fatty
liver
disease
(NAFLD)
and
chronic
kidney
(CKD)
are
both
closely
related
to
dyslipidemia.
However,
the
relationship
between
dyslipidemia
in
patients
with
NAFLD
CKD
is
not
yet
clear.
The
non-high-density
lipoprotein
cholesterol
high-density
ratio
(NHHR)
an
innovative
comprehensive
lipid
index.
purpose
of
this
study
was
investigate
correlation
NHHR
risk
or
without
fibrosis.
Methods
This
used
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2017
2020
for
analysis,
including
a
total
4,041
subjects
diagnosed
NAFLD.
Among
subjects,
3,315
individuals
fibrosis
726
Weighted
multivariate
linear
regression,
weighted
logistic
restricted
cubic
spline
(RCS)
curves,
subgroup
analysis
were
evaluate
Results
Our
findings
indicate
that
fibrosis,
highest
tertile
NHHR,
as
compared
lowest
tertile,
inversely
glomerular
filtration
rate
(eGFR)
(
β
:
−2.14,
95%
CI:
−3.97,
−0.32,
p
<
0.05)
positively
(OR:
1.67,
1.12,
2.49,
0.05).
No
significant
associations
observed
eGFR,
urinary
albumin
creatinine
(ACR)
RCS
revealed
ACR,
while
U-shaped
Conclusion
In
non-fibrotic
NAFLD,
significantly
elevated
associated
increased
shows
CKD.
fibrotic
LD,
underscore
practical
utility
biomarker
early
stratification
