High sensitivity C-reactive protein implicates heterogeneous metabolic phenotypes and severity in metabolic dysfunction associated-steatotic liver disease DOI Creative Commons
Hao Wang, Junzhao Ye, You‐Peng Chen

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 8, 2025

Language: Английский

Regular exercise alleviates metabolic dysfunction-associated steatohepatitis through rescuing mitochondrial oxidative stress and dysfunction in liver DOI
Baoxuan Lin, Tong Wu, Mohammad Nasb

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Dapansutrile Regulates Mitochondrial Oxidative Stress and Reduces Hepatic Lipid Accumulation in Diabetic Mice DOI Creative Commons
Ying Wu,

Jiaqiang Zhou

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 148 - 148

Published: Feb. 25, 2025

(1) Background: Hepatic lipid accumulation is the initial factor in metabolic-associated fatty liver disease (MAFLD) type 2 diabetics, leading to accelerated damage. The NOD-like receptor protein 3 (NLRP3) inflammasome plays a critical role this process. Dapansutrile (DAPA) novel NLRP3 inhibitor; however, its effect on ectopic remains unclear. This study aimed investigate therapeutic of DAPA hepatic diabetic mouse model and potential mechanisms. (2) Methods: effects deposition function under metabolic stress were evaluated vivo using db/db high-fat diet (HFD) + streptozotocin (STZ) models. Additionally, mechanism cellular deposition, mitochondrial oxidative stress, inflammation assessed HepG2 cells treated with free acids (FFA) DAPA. (3) Results: Our findings indicated that treatment improved glucose metabolism mice, particularly addressing heterotopic insulin resistance. also ameliorated mitochondrial-related functions through NLRP3-Caspase-1 signaling axis. (4) Conclusions: Targeting may represent approach for diabetes-related diseases.

Language: Английский

Citations

0
Analysis of Risk Factors of Non-Alcoholic Fatty Liver Disease in Elderly Patients DOI

梦茹 徐

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 1639 - 1645

Published: Jan. 1, 2025

Language: Английский

Citations

0
High-Fat Diet and Altered Radiation Response DOI Creative Commons
Jiraporn Kantapan, Takanori Katsube, Bing Wang

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 324 - 324

Published: March 22, 2025

High-fat diets (HFDs) have become increasingly prevalent in modern societies, driving rising rates of obesity and metabolic syndrome. Concurrently, radiation exposure from medical treatments environmental sources poses health risks shaped by both biological factors. This review explores the intersection between HFDs sensitivity/susceptibility, focusing on how diet-induced alterations influence body’s response to radiation. Evidence preclinical clinical studies indicates that significantly alter metabolism, leading increased oxidative stress immune system dysregulation. These changes can exacerbate radiation-induced stress, inflammation, DNA damage, potentially increasing sensitivity normal tissues. Conversely, HFD-induced disruptions may activate cellular pathways involved repair, cell survival, inflammatory responses, fostering tumor resistance modifying microenvironment, which impair efficacy therapy cancer treatment. Understanding interplay diet is critical for optimizing public guidelines improving therapeutic outcomes. findings underscore need further research into dietary interventions mitigate radiation-associated risks.

Language: Английский

Citations

0
High sensitivity C-reactive protein implicates heterogeneous metabolic phenotypes and severity in metabolic dysfunction associated-steatotic liver disease DOI Creative Commons
Hao Wang, Junzhao Ye, You‐Peng Chen

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 8, 2025

Language: Английский

Citations

0