Bone, Journal Year: 2024, Volume and Issue: 189, P. 117255 - 117255
Published: Sept. 14, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4164 - 4164
Published: Nov. 30, 2024
The dietary index for gut microbiota (DI-GM) is a newly proposed metric assessing diet quality, and its relationship with biological age unclear. We hypothesize that consuming foods conducive to healthy environment may decelerate aging.
Language: Английский
Citations
4
Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: 34(3), P. 108238 - 108238
Published: Jan. 12, 2025
This study aims to explore the association between Life's Essential 8 (LE8) and stroke all-cause mortality, compare whether it has an advantage over Simple 7 (LS7). investigated data from NHANES spanning 1999 2018. The LE8 was categorized as low, moderate high cardiovascular health (CVH). LS7 score inadequate, average, or optimal. Weighted logistic regression restricted cubic spline (RCS) were used examin correlations. Receiver operating characteristic (ROC) curves employed detect accuracy in predicting stroke. stratified sensitivity analyses conducted along with mediation analysis. In addition, a longitudinal cohort constructed by combining mortality data, Cox models utilized determine CVH rate. For LE8, compared low CVH, associated 41% lower risk of stroke, 71% prevalence LS7, inadequate average 24% optimal 39% RCS showed inverse dose-response relationships both unweighted ROC, (AUC=0.702, 95% CI: 0.685-0.718, P<0.001) stronger ability discriminate than (0.677, 0.658-0.696, (PDeLong=0.046). Sensitivity demonstrated robustness GGT WBC mediated 4.92% 4.58% association, respectively. neither nor predictive among survivor. outperformed classifying Oxidative stress inflammation
Language: Английский
Citations
0
International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17
Published: Jan. 12, 2025
Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in National Health Nutrition Examination Survey 2005–2010, phenol, paraben, phthalate concentrations were measured phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression weighted quantile sum (WQS) used evaluate associations single mixed PhenoAgeAccel. Stratified analyses by chronological lifestyle also performed. Individual positively associated The WQS model found positive relationship between PhenoAgeAccel (β = 0.175, 95%CI: 0.001, 0.349). adverse impacts phenols stronger older participants significant interactions. Adherence healthier might partly reduce relationships aging, especially among adults, which is expected be a viable intervention future.
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 1, 2025
Abstract Objectives Life's essential 8 (LE8) is an emerging approach for accessing and quantifying cardiovascular health (CVH), but the effect on Parkinson's disease (PD) still unclear. This study aimed to elucidate association between LE8 metrics PD in US adults. Methods Data of 26,975 participants were extracted from last 7 National Health Nutrition Examination Survey (NHANES) cycles (2005–2018). The calculated according American Heart Association criterion, divided into 3 groups using tertile range. Multivariate logistic regression models constructed explore PD. Sensitivity analysis was conducted verify robustness. A nonlinear linkage evaluated via restricted cubic spline (RCS). stability this validated by subgroup interaction test. Results total eligible (including 271 cases 26,704 non-PD cases) included study. multivariate revealed a reverse continuous with ORs 0.97 (unadjusted model [95% CI: 0.96–0.98, P < 0.01], partially adjusted 0.97–0.98, fully 0.95–0.98, 0.01]). Compared those low group, high group 0.37 (95% 0.27–0.50, 0.01) unadjusted model, 0.51 0.36–0.72, 0.32–0.81, model. sensitivity ensured robustness observed LE8-PD association. relationship ( nonlinearity RCS analysis. showed that participants'gender might impact strength metrics-PD = 0.029). Conclusions CVH, as delineated metrics, reversely associated dose–response pattern, more pronounced female compared male. These findings highlight potential guide targeted strategies addressing gender-based CVH disparities, offering beneficial insights tertiary prevention
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 20, 2025
The "Life's Essential 8" (LE8) is a comprehensive lifestyle assessment tool by the American Heart Association, designed to mitigate cardiovascular disease risk optimizing factors including diet, physical activity, and other health metrics. While individual components of LE8 have been linked reduced cancer risks, studies on score trajectories over time their relation are lacking. This study employed Kailuan cohort, involving 48,330 participants who underwent three examinations from 2006 2010 determine scores. were analyzed using latent mixture modeling, association with incident risks was assessed through Cox proportional hazard models, adjusting for confounders such as age, biological sex, behaviors. Three distinct trajectory patterns identified: low-stable (21.2%), moderate-stable (49.4%), elevated-stable (29.4%). Participants showed 21% (HR = 0.79; 95% CI: 0.70–0.90), 27% 0.73, 0.57–0.92), 51% 0.49, 0.32–0.77), 31% 0.69, 0.50–0.97) 39% 0.61, 0.39–0.95) reduction in overall, lung, breast, colorectal liver compared those Notably, protective effect scores against breast pronounced elevated CRP levels, indicating an interaction between inflammation trajectories. Maintaining high stable significantly associated risk, underscoring importance integrating into public clinical strategies prevention. study, ChiCTR–TNRC–11,001,489. Registered August 24, 2011-Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=8050 .
Language: Английский
Citations
0
npj Aging, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 12, 2025
This study investigates the relationship between physical activity (PA) levels and DNA methylation (DNAm)-predicted epigenetic clocks in a U.S. population sample (n = 948, mean age 62, 49% female). Eight were analyzed, revealing that higher PA significantly associated with younger biological ages across all indicators, strongest effects observed for SkinBloodAge LinAge. Multivariable linear regression models, adjusted sociodemographic lifestyle factors, highlighted potential of to reduce ageing. Subgroup analyses indicated these associations more pronounced among non-Hispanic whites, individuals BMI 25-30, former smokers, suggesting impact varies different groups. These findings emphasize role slowing ageing reducing age-related health risks. Promoting regular PA, especially older adults those BMI, could improve well-being lifespan, highlighting as modifiable factor healthy disease prevention.
Language: Английский
Citations
0
The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(7), P. 100557 - 100557
Published: April 17, 2025
To explore the association of Life's Essential 8 (LE8) levels with leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN). A cross-sectional study. 225,692 participants aged 37-73 year from UK Biobank cohort enrolled 2006 to 2010. The LE8 score (0-100) was divided into low (<50), moderate (50-79), high cardiovascular health (CVH) (≥80) categories, based on behaviors factors defined by American Heart Association. LTL measured a validated quantitative polymerase chain reaction method. mtDNA-CN reacted standardized SNP probe intensities. CVH (as both continuous categorical variable) examined using multiple linear regression. Of participants, 5.3% had CVH, 81.2% 13.4% CVH. Participants higher were usually younger, female, better educated, socioeconomic status, lower prevalence comorbidities. After adjusting for confounders, is associated longer (Beta = 0.075, P < 0.05) increased 0.094, 0.05). We also observed that this evident in behavior (diet, physical activity, nicotine exposure, sleep) (BMI, non-HDL cholesterol, blood glucose, pressure), stronger positive 0.019, 0.05; Beta 0.037, Higher mtDNA-CN.
Language: Английский
Citations
0
Drugs & Aging, Journal Year: 2024, Volume and Issue: 41(9), P. 699 - 712
Published: Aug. 10, 2024
Language: Английский
Citations
3
Clinical Cardiology, Journal Year: 2024, Volume and Issue: 47(4)
Published: April 1, 2024
Abstract Background Earlier studies showed a negative correlation between life's simple 7 (LS7) and high‐sensitivity C‐reactive protein (hs‐CRP), but no association has been found essential 8 (LE8), an improved version of LS7, hs‐CRP. Hypothesis This study investigated the LE8 hs‐CRP utilizing data from National Health Nutritional Examination Survey. Methods A total 7229 adults were incorporated in our study. was scored according to American Heart Association guidelines, divided into health behaviors factors. Serum samples participants used measure To investigate hs‐CRP, weighted linear regression, restricted cubic spline utilized. Results Among participants, average age 48.03 ± 16.88 years, 3689 (51.2%) females median 1.92 (0.81−4.49) mg/L. In adjusted observed score Compared with low score, moderate β −0.533 (−0.646 −0.420), high −1.237 (−1.376 −1.097). factors also negatively associated stratified analyses, remained consistent across subgroups. Conclusion There as well its sub‐indicator scores Maintaining positive may be conducive lowering level
Language: Английский
Citations
2
Journal of Aging Research and Lifestyle, Journal Year: 2024, Volume and Issue: 13, P. 88 - 92
Published: Jan. 1, 2024
Biological age is a concept that uses bio-physiological parameters to account for individual heterogeneity in the biological processes driving aging and aims enhance prediction of age-related clinical conditions compared chronological age. Although engaging healthy lifestyle behaviors has been linked lower mortality risk reduced incidence chronic diseases, it remains unclear what extent these health benefits result from slowing pace process. This short review summarized how modifiable factors - including diet, physical activity, smoking, alcohol consumption, aggregate multiple were associated with established estimates based on or cellular/molecular markers, Klemera-Doubal Method age, homeostatic dysregulation, phenotypic DNA methylation telomere length. In brief, available studies tend show consistent association physiological measures while findings regarding molecular-based metrics vary. The limited evidence highlights need further research this field, particularly life-course approach.
Language: Английский
Citations
2