Theranostics,
Journal Year:
2024,
Volume and Issue:
15(4), P. 1496 - 1523
Published: Dec. 31, 2024
The
human
body
is
an
intricate
system,
where
diverse
and
complex
signaling
among
different
organs
sustains
physiological
activities.
eye,
as
a
primary
organ
for
information
acquisition,
not
only
plays
crucial
role
in
visual
perception
but
also,
increasing
evidence
suggests,
exerts
broad
influence
on
the
entire
through
circuits
upon
receiving
light
signals
which
called
non-image-forming
vision.
However,
extent
mechanisms
of
light's
impact
eyes
remain
insufficiently
explored.
There
also
dearth
comprehensive
reviews
elucidating
interplay
between
light,
systemic
connections
to
body.
Herein,
we
propose
concept
light-eye-body
axis
systematically
encapsulate
extensive
effects
received
by
retina
We
reviewed
visual-neural
structure
basis
axis,
summarized
mechanism
regulate
whole
current
research
status
challenges
within
pathological
processes
involved
axis.
Future
should
aim
expand
explore
its
deeper
mechanisms.
Understanding
investigating
will
contribute
improving
lighting
conditions
optimize
health
guide
establishment
phototherapy
standards
clinical
practice.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(6), P. 758 - 758
Published: June 9, 2024
Accidental
poisonings
by
ingesting
conjunctival
fluid
mixed
with
eye
drops
commonly
involve
alpha-2
adrenergic
receptor
agonists
and
tetrahydrozoline.
These
substances
are
recognized
in
reported
ingestions.
Victims
of
all
ages,
otherwise
good
health,
often
present
as
pale
lethargic
to
the
emergency
department
(ED)
after
unintentionally
topical
medication.
While
drop
poisoning
cases
childhood
include
accidents
during
play
adults
mean
either
suicide
attempts
or
side
effects
caused
systemic
absorption
substance,
ocular
surface
is
a
risk
age
groups.
With
this
mind,
study
aimed
summarize
data
literature
on
tetrahydrozoline
dangerous
medications,
even
when
administered
low-bioavailability
forms,
such
drops.
aim,
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
(PRISMA)-compliant
systematic
review
relevant
studies
was
conducted.
A
search
PubMed,
Scopus,
Web
Science,
EBSCOhost
yielded
nine
that
met
rigorous
inclusion
criteria.
The
primary
were
subject
meta-analysis
once
quality
appraisal
narrative
synthesis
extracted
had
been
author
hopes
information
will
provide
observations
lead
better
designs
over-the-counter
drops,
off-label
drug
usage
policies,
parental
attention.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 8, 2024
Abstract
Neuroinflammation
is
a
pathological
process
mediated
through
immune
cell
activation
and
pro-inflammatory
cytokine
release,
resulting
in
neuronal
death.
In
the
central
nervous
system
(CNS),
neuroinflammation
characteristic
feature
underlying
onset
progression
of
retinal
neurodegenerative
diseases.
Targeting
to
reduce
death
protect
against
visual
cognitive
declines
therefore
key
therapeutic
strategy.
However,
due
complex
multi-faceted
nature
these
diseases,
date
there
has
been
little
success
with
single
target
approaches
insufficient
tackle
widespread
multi-pathway
inflammatory
cascades.
Furthermore,
as
retina
brain
reside
within
immune-privileged
environments,
major
challenge
treating
diseases
producing
delivering
that,
itself,
does
not
exacerbate
inflammation.
Extracellular
vesicles
(EV),
derived
from
red
blood
cells
(RBC
EV),
present
promising
solution
overcome
hurdles,
their
innate
ability
cross
blood-tissue
barriers,
biocompatible
nature,
broad
anti-inflammatory
properties
modulate
neuroinflammatory
pathways.
This
study
investigated
potential
RBC
EV
mediating
using
an
in-vivo
photo-oxidative
damage
model
degeneration
for
CNS
neuroinflammation.
this
work,
we
developed
novel
incubation
pipeline
N1
medium
supplement
superoxide
dismutase
(SOD)
supplementation
promote
production
safe,
neuroprotective,
EV.
Delivery
vivo
,
was
shown
be
safe
strong
penetration
across
all
layers.
Further,
administration
via
local
intravitreal
injection
significantly
reduced
inflammation
preserved
function.
Notably,
safety
efficacy
also
demonstrated
following
systemic
(intraperitoneal)
administration,
highlighting
game-changing
approach
less-invasive
delivery
CNS.
Finally,
multi-omic
analyses
vitro
findings
supported
mechanism-of-action,
modulating
including
those
known
involved
pathogenesis
Taken
together,
highlight
applicability
CNS,
presenting
scalable
effective
treatment
currently
untreatable
Investigative Ophthalmology & Visual Science,
Journal Year:
2024,
Volume and Issue:
65(13), P. 26 - 26
Published: Nov. 14, 2024
Purpose:
The
purpose
of
this
study
was
to
examine
the
association
between
refractive
errors
and
common
chronic
diseases
using
blood
biochemistry
tests,
investigate
associated
modifiable
risk
factors,
with
goal
informing
developing
effective
preventive
strategies.
Methods:
A
total
116,245
participants
refractometry
at
baseline
enrolled
in
UK
Biobank
were
included
prospective
cohort
study.
Restricted
cubic
spline
Cox
proportional
hazards
models
used
detect
associations
error,
diseases.
Interaction
effects
on
additive
scale
effect
modification
analysis
explore
excess
factors
for
disease
prevention.
Results:
Spherical
equivalent
significantly
vitamin
D,
sex
hormone
binding
globulin,
apolipoprotein
A,
glucose,
aspartate
aminotransferase
levels.
Subjects
myopia
demonstrated
a
13%
higher
type
2
diabetes
mellitus
(T2DM)
incidence
compared
those
without
(hazard
ratio
[HR]
=
1.13,
95%
confidence
interval
[CI]
1.08–1.19)
throughout
median
follow-up
9.12
years.
revealed
15%
(95%
CI
9%–21%)
due
myopia-obesity
interaction.
However,
active
engagement
physical
activity
could
potentially
mitigate
(HR
1.06,
0.93–1.20).
Conclusions:
Refractive
specific
indicators,
particularly
noting
T2DM
middle-aged
elderly
populations.
This
interacts
obesity,
promoting
among
individuals
provides
greater
benefits
prevention
non-myopic
individuals.
Theranostics,
Journal Year:
2024,
Volume and Issue:
15(4), P. 1496 - 1523
Published: Dec. 31, 2024
The
human
body
is
an
intricate
system,
where
diverse
and
complex
signaling
among
different
organs
sustains
physiological
activities.
eye,
as
a
primary
organ
for
information
acquisition,
not
only
plays
crucial
role
in
visual
perception
but
also,
increasing
evidence
suggests,
exerts
broad
influence
on
the
entire
through
circuits
upon
receiving
light
signals
which
called
non-image-forming
vision.
However,
extent
mechanisms
of
light's
impact
eyes
remain
insufficiently
explored.
There
also
dearth
comprehensive
reviews
elucidating
interplay
between
light,
systemic
connections
to
body.
Herein,
we
propose
concept
light-eye-body
axis
systematically
encapsulate
extensive
effects
received
by
retina
We
reviewed
visual-neural
structure
basis
axis,
summarized
mechanism
regulate
whole
current
research
status
challenges
within
pathological
processes
involved
axis.
Future
should
aim
expand
explore
its
deeper
mechanisms.
Understanding
investigating
will
contribute
improving
lighting
conditions
optimize
health
guide
establishment
phototherapy
standards
clinical
practice.
