IL-2/anti-IL-2 complexes attenuates neuroinflammation and neurodegeneration in mice of experimental Parkinson's disease.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111273 - 111273

Published: Feb. 1, 2025

Language: Английский

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Role of Epigenetic Modulation in Neurodegenerative Diseases: Implications of Phytochemical Interventions

Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 606 - 606

Published: May 15, 2024

Epigenetics defines changes in cell function without involving alterations DNA sequence. Neuroepigenetics bridges neuroscience and epigenetics by regulating gene expression the nervous system its impact on brain function. With increase research recent years, it was observed that did not always originate from genetic sequence, which has led to understanding role of neurodegenerative diseases (NDDs) including Alzheimer's disease (AD) Parkinson's (PD). Epigenetic contribute aberrant genes involved neuroinflammation, protein aggregation, neuronal death. Natural phytochemicals have shown promise as potential therapeutic agents against NDDs because their antioxidant, anti-inflammatory, neuroprotective effects cellular animal models. For instance, resveratrol (grapes), curcumin (turmeric), epigallocatechin gallate (EGCG; green tea) exhibit through influence methylation patterns, histone acetylation, non-coding RNA profiles. Phytochemicals also aid slowing progression, preserving function, enhancing cognitive motor abilities. The present review focuses various epigenetic modifications pathology NDDs, AD PD, regulation related alterations, specific polyphenols influencing PD.

Language: Английский

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MicroRNAs in microglia: deciphering their role in neurodegenerative diseases

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: May 15, 2024

This review presents a comprehensive analysis of the role microRNAs in microglia and their implications pathogenesis neurodegenerative diseases. Microglia, as resident immune cells central nervous system (CNS), are pivotal maintaining neural homeostasis responding to pathological changes. Recent studies have highlighted significance miRNAs, small non-coding RNA molecules, regulating microglial functions. In diseases, such Alzheimer’s Disease (AD), Parkinson’s (PD), Amyotrophic Lateral Sclerosis (ALS), Multiple (MS), dysregulated miRNA expression contributes disease progression through various mechanisms regulation gene expression, modulation cytokine response phagocytosis. synthesizes current knowledge on how miRNAs influence activation, production, phagocytic activity. Specific miR-155, explored for roles modulating responses context neuroinflammation neurodegeneration. The study also discusses impact dysregulation transition from neuroprotective neurotoxic phenotype, critical aspect

Language: Английский

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Neuroinflammation in Parkinson’s disease: focus on the relationship between miRNAs and microglia

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 26, 2024

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects the central nervous system (CNS). Neuroinflammation crucial factor in pathological advancement of PD. PD characterized by presence activated microglia and increased levels proinflammatory factors, which play role its pathology. During immune response PD, regulation significantly influenced microRNA (miRNA). The excessive activation microglia, persistent neuroinflammation, abnormal polarization macrophages brain can be attributed to dysregulation certain miRNAs. Additionally, there are miRNAs possess ability inhibit neuroinflammation. miRNAs, small non-coding epigenetic regulators, have modulate microglial activity both normal conditions. They also significant impact on promoting communication between neurons microglia.

Language: Английский

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Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits

EMBO Molecular Medicine, Journal Year: 2024, Volume and Issue: 16(4), P. 678 - 699

Published: March 11, 2024

Language: Английский

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Identification of Downregulated MECR Gene in Parkinson’s Disease Through Integrated Transcriptomic Analysis and Validation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 550 - 550

Published: Jan. 10, 2025

Parkinson's disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein (α-syn) aggregation. Lipid metabolism dysfunction may contribute to PD progression. This study aims identify lipid metabolism-related genes (LMGs) associated with using an integrative transcriptomic analysis of microarray single-cell RNA sequencing (scRNA-seq) datasets from patients healthy controls. Differentially expressed (DEGs) related were identified, key further filtered weighted gene co-expression network (WGCNA) machine learning algorithms. Four LMGs, AGPAT2, ASAH2, FA2H, MECR being notably downregulated in both bulk analyses patients. downregulation was validated α-syn PFF-induced models. Virtual screening molecular simulations identified potential allosteric modulators MECR, which offer pathway for future therapeutic exploration. highlights as critical link between PD, suggesting the need investigation into its implications.

Language: Английский

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RBM15 relies on m6A modification to inhibit UBE2C, alleviating hippocampal neuronal injury by limiting microglial inflammation

Molecular and Cellular Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 103996 - 103996

Published: March 1, 2025

Language: Английский

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Suppression of miR-218 promotes SOCS3 expression to alleviate cognitive impairment and white matter injury after chronic cerebral hypoperfusion

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(3)

Published: March 13, 2025

Language: Английский

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microRNAs as molecular tools for brain health: Neuroprotective potential in neurodegenerative disorders

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Characterizing Secondary and Atypical Parkinsonisms: Defining Features and Clinical Variability

Neuroglia, Journal Year: 2024, Volume and Issue: 5(4), P. 467 - 487

Published: Nov. 28, 2024

Parkinsonism is a clinical syndrome characterized by akinesia/bradykinesia, muscle rigidity, resting tremor, and postural instability. Within the group of parkinsonisms Parkinson’s disease, also known as neurodegenerative parkinsonian syndrome. The atypical was established due to existence sporadic that do not share exact etiology disease. Additionally, arise from causes other than neurodegeneration have been classified secondary parkinsonisms. With this in mind, given diversity etiologies can trigger parkinsonism, it crucial understand symptomatology its relationship with basal ganglia (including damage nigrostriatal pathway, neuroinflammation, neuronal damage). Only then will be possible propose appropriate treatments for each variant parkinsonism.

Language: Английский

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