Differential Replication and Oncolytic Effects of Zika Virus in Aggressive CNS Tumor Cells: Insights from Organoid and Tumoroid Models
Viruses,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1764 - 1764
Published: Nov. 12, 2024
Central
nervous
system
(CNS)
cancers
are
responsible
for
high
rates
of
morbidity
and
mortality
worldwide.
Malignant
CNS
tumors
such
as
adult
Glioblastoma
(GBM)
pediatric
embryonal
medulloblastoma
(MED)
atypical
teratoid
rhabdoid
(ATRT)
present
relevant
therapeutic
challenges
due
to
the
lack
response
classic
treatment
regimens
with
radio
chemotherapy.
Recent
findings
on
Zika
virus’
(ZIKV)
ability
infect
kill
neoplastic
cells
draw
attention
oncolytic
potential.
Studies
demonstrating
safety
using
ZIKV
treating
malignant
tumors,
enabling
translation
this
approach
clinical
trials,
scarce
in
literature.
Here
we
developed
a
co-culture
model
mature
human
cerebral
organoids
assembled
GBM,
MED
or
ATRT
tumor
used
these
assembloids
test
effect,
replication
potential
preferential
targeting
between
normal
cancer
cells.
Our
hybrid
models
allowed
tracking
cell
growth
invasion
organoids.
ensuing
accumulation
culture
medium
was
higher
co-cultured
than
isolated
control
without
infection
led
significant
reduction
proportion
GBM
cells,
but
not
ATRT.
Tumoroids
(3D
cultures
alone)
were
efficiently
infected
by
ZIKV.
Interestingly,
rapidly
replicated
MED,
tumoroids
reaching
significantly
viral
RNA
levels
co-cultures.
Moreover,
reduced
viable
number
tumoroids.
Altogether,
our
indicate
that
has
greater
aggressive
comprising
However,
does
necessarily
parallels
effects,
suggesting
cellular
intrinsic
extrinsic
factors
mediating
death
Language: Английский
Forms of Non-Apoptotic Cell Death and Their Role in Gliomas—Presentation of the Current State of Knowledge
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(7), P. 1546 - 1546
Published: July 11, 2024
In
addition
to
necrosis
and
apoptosis,
the
two
forms
of
cell
death
that
have
been
known
for
many
decades,
other
non-apoptotic
discovered,
which
also
play
a
role
in
tumors.
Starting
with
description
autophagy
more
than
60
years
ago,
newer
become
important
biology
tumors,
such
as
ferroptosis,
pyroptosis,
necroptosis,
paraptosis.
this
review,
all
oncologically
relevant
programmed
are
presented,
starting
their
first
descriptions,
molecular
characteristics,
interactions
physiology
pathophysiology.
Based
on
these
current
state
knowledge
about
alterations
gliomas
will
be
presented.
addition,
efforts
therapeutically
influence
components
discussed.
Although
research
into
exact
is
still
at
rather
early
stage,
our
review
clarifies
show
significant
insight
understanding
them
has
already
gained.
Language: Английский
Towards Effective Treatment of Glioblastoma: The Role of Combination Therapies and the Potential of Phytotherapy and Micotherapy
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(12), P. 14324 - 14350
Published: Dec. 19, 2024
Glioblastoma
multiforme
(GBM)
is
one
of
the
most
aggressive
and
difficult-to-treat
brain
tumors,
with
a
poor
prognosis
due
to
its
high
resistance
conventional
therapies.
Current
treatment
options,
including
surgical
resection,
radiotherapy,
chemotherapy,
have
limited
effectiveness
in
improving
long-term
survival.
Despite
emergence
new
therapies,
monotherapy
approaches
not
shown
significant
improvements,
highlighting
need
for
innovative
therapeutic
strategies.
Combination
therapies
appear
be
promising
solution,
as
they
target
multiple
molecular
pathways
involved
GBM
progression.
One
area
growing
interest
incorporation
phytotherapy
micotherapy
complementary
treatments,
which
offer
potential
benefits
their
anti-tumor,
anti-inflammatory,
immunomodulatory
properties.
This
review
examines
current
challenges
treatment,
discusses
combination
highlights
role
integrative
options
management.
Language: Английский
A comprehensive neuroimaging review of the primary and metastatic brain tumors treated with immunotherapy: current status, and the application of advanced imaging approaches and artificial intelligence
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 28, 2024
Cancer
immunotherapy
has
emerged
as
a
novel
clinical
therapeutic
option
for
variety
of
solid
tumors
over
the
past
decades.
The
application
in
primary
and
metastatic
brain
continues
to
grow
despite
limitations
due
physiological
characteristics
immune
system
within
central
nervous
(CNS)
distinct
pathological
barriers
malignant
tumors.
post-immunotherapy
treatment
imaging
is
more
complex.
In
this
review,
we
summarize
immunotherapies
beyond
CNS.
We
provide
an
overview
current
used
tumors,
including
checkpoint
inhibitors
(ICIs),
oncolytic
viruses,
vaccines,
CAR
T-cell
therapies.
focus
on
criteria
assessment
response
immunotherapy,
patterns.
discuss
advanced
techniques
evaluation
treatment-related
complications
CNS
are
described.
Lastly,
future
challenges
field
explored.
Language: Английский