Mitochondria in skeletal system-related diseases DOI Open Access

Liang Pei,

Zizhen Yao, Liang Dong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117505 - 117505

Published: Nov. 4, 2024

Language: Английский

CircRNA and lncRNA-encoded peptide in diseases, an update review DOI Creative Commons
Qian Yi,

Jianguo Feng,

Weiwu Lan

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 30, 2024

Language: Английский

Citations

13
Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases DOI
Xinyue Zhou,

Yajie Wu,

Yingqiu Song

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Jan. 7, 2025

Language: Английский

Citations

1
Assessing causality between mitochondrial-associated proteins with musculoskeletal diseases: A Mendelian randomization study DOI Creative Commons
Jiachen Li,

Wen-bao Huang,

Deyi Yang

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(10), P. e41731 - e41731

Published: March 7, 2025

Musculoskeletal diseases are the leading cause of disability-adjusted life years. Mitochondria, often referred to as "powerhouses" cells, believed play a role in regulating cellular metabolism and differentiation, potentially influencing occurrence progression musculoskeletal diseases. However, exact causal relationships remain be defined. This study aimed investigate between mitochondrial biological functions (including osteoarthritis (OA), osteoporosis, rheumatoid arthritis (RA), ankylosing spondylitis through Mendelian randomization (MR) analysis). We systematically summarized data related functional proteins from IEU OpenGWAS UK Biobank databases. used single nucleotide polymorphisms significantly associated with instrumental variables. The inverse variance weighting method performed main MR analysis. randomized residual sum pleiotropy outliers, MR-Egger regression, Cochran Q statistic, Rucker Radial-MR, weighted median, simple mode, leave-one-out analysis methods supplementary analyses. First, 14 positive were screened out. After Bonferroni correction, COA3 COX4I2 found causally OA act protective factors. identified relationship SLC25A18 RA risk factor. provides genetic support offers new evidence regarding roles COA3, COX4I2, pathophysiology RA. paves way for deeper understanding pathological mechanisms information their prevention strategies treatments.

Language: Английский

Citations

0
Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders DOI Creative Commons
Hongbin Sun, Chao Xu,

Zhilin Xiong

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

With the global population aging, musculoskeletal disorders (MSDs) have posed significant physical and psychological health challenges for patients as well a substantial economic burden on society. The advancements in conservative surgical interventions MSDs been remarkable recent years; however, current treatment modalities still fall short of meeting optimal requirements patients. Recently, peroxiredoxin 6 (Prdx6) has gained considerable attention from researchers due to its antioxidative, anti-inflammatory, anti-apoptotic properties. It found that Prdx6 is involved multiple system diseases, including MSDs; exact role lacking. This study aimed summarize structure, regulatory mechanism, potential function Prdx6. These findings may demonstrate novel target inhibiting advancement MSDs.

Language: Английский

Citations

0
Mitochondria in skeletal system-related diseases DOI Open Access

Liang Pei,

Zizhen Yao, Liang Dong

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117505 - 117505

Published: Nov. 4, 2024

Language: Английский

Citations

1