BME Frontiers,
Journal Year:
2024,
Volume and Issue:
6
Published: Jan. 13, 2024
Spatial
monoomics
has
been
recognized
as
a
powerful
tool
for
exploring
life
sciences.
Recently,
spatial
multiomics
advanced
considerably,
which
could
contribute
to
clarifying
many
biological
issues.
techniques
in
epigenomics,
genomics,
transcriptomics,
proteomics,
and
metabolomics
can
enhance
our
understanding
of
functions
cellular
identities
by
simultaneously
measuring
tissue
structures
biomolecule
levels.
technology
evolved
from
multiomics.
Moreover,
the
resolution,
high-throughput
detection
capability,
capture
efficiency,
compatibility
with
various
sample
types
omics
have
considerably
advanced.
Despite
technological
advances
this
field,
data
analysis
frameworks
stagnated.
Current
challenges
include
incomplete
pipeline,
overly
complex
tasks,
few
established
strategies.
In
review,
we
systematically
summarize
recent
developments
improvements
related
pipeline.
On
basis
technology,
propose
integration
strategy
cross-platform,
cross-slice,
cross-modality.
We
potential
applications
aiming
provide
researchers
clinicians
better
how
such
is
expected
substantially
impact
biology
precision
medicine
through
measurements
extraction
biomolecular
features.
Oncology Reports,
Journal Year:
2024,
Volume and Issue:
53(1)
Published: Nov. 8, 2024
Gastrointestinal
(GI)
cancers,
which
have
notable
incidence
and
mortality,
are
impacted
by
metabolic
reprogramming,
especially
the
increased
production
accumulation
of
lactate.
Lactylation,
a
post‑translational
modification
driven
lactate,
is
crucial
regulator
gene
expression
cellular
function
in
GI
cancer.
The
present
review
aimed
to
examine
advancements
understanding
lactate
lactylation
mechanisms
production,
its
influence
on
tumor
microenvironment
clinical
implications
levels
as
potential
biomarkers
were
explored.
Furthermore,
was
investigated,
including
biochemical
foundation,
primary
targets
functional
outcomes.
underscored
therapeutic
strategies
targeting
metabolism
lactylation.
Challenges
future
directions
emphasize
innovative
cancer
improve
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: Nov. 28, 2024
Gastric
cancer
(GC)
is
a
malignant
tumor
associated
with
significant
rates
of
morbidity
and
mortality.
Hence,
developing
efficient
predictive
models
directing
clinical
interventions
in
GC
crucial.
Lactylation
proteins
detected
gastric
tumors
linked
to
the
advancement
cancer.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(23)
Published: Dec. 1, 2024
ABSTRACT
Glycolysis‐related
lactylation
has
gained
wide
attention
for
regulating
various
cellular
functions
and
diseases.
Nevertheless,
its
intricate
involvement
in
intervertebral
disc
degeneration
(IVDD)
is
not
yet
fully
understood.
In
this
study,
we
unrevealed
the
association
between
elevated
levels
development
of
IVDD.
Subsequently,
harvested
lactylation‐related
genes
(LRGs)
systematically
analysed
expression
these
to
establish
a
gene
signature
related
IVDD
through
multiple
bulk
RNA
sequencing
data.
Six
hub
LRGs
were
determined
closely
associated
with
increased
severity
Among
six
genes,
CBX3
was
most
upregulated
both
vivo
vitro
experiments.
Furthermore,
molecular
docking
identified
atosiban
acetate
as
specific
inhibitor
CBX3,
inhibiting
using
significantly
repressed
glycolysis
activity
global
level,
thus
alleviating
progression
conclusion,
correlates
positively
LRG
could
be
used
biomarker
effective
clinical
treatment
emerged
one
key
IVDD,
acetate,
may
promising
therapeutic
candidate
by
affecting
lactylation.
BME Frontiers,
Journal Year:
2024,
Volume and Issue:
6
Published: Jan. 13, 2024
Spatial
monoomics
has
been
recognized
as
a
powerful
tool
for
exploring
life
sciences.
Recently,
spatial
multiomics
advanced
considerably,
which
could
contribute
to
clarifying
many
biological
issues.
techniques
in
epigenomics,
genomics,
transcriptomics,
proteomics,
and
metabolomics
can
enhance
our
understanding
of
functions
cellular
identities
by
simultaneously
measuring
tissue
structures
biomolecule
levels.
technology
evolved
from
multiomics.
Moreover,
the
resolution,
high-throughput
detection
capability,
capture
efficiency,
compatibility
with
various
sample
types
omics
have
considerably
advanced.
Despite
technological
advances
this
field,
data
analysis
frameworks
stagnated.
Current
challenges
include
incomplete
pipeline,
overly
complex
tasks,
few
established
strategies.
In
review,
we
systematically
summarize
recent
developments
improvements
related
pipeline.
On
basis
technology,
propose
integration
strategy
cross-platform,
cross-slice,
cross-modality.
We
potential
applications
aiming
provide
researchers
clinicians
better
how
such
is
expected
substantially
impact
biology
precision
medicine
through
measurements
extraction
biomolecular
features.
