Assessment of cephalometric parameters and correlation with the severity of the obstructive sleep apnea syndrome
Eugenio Garofalo,
No information about this author
Giuseppe Neri,
No information about this author
Lucilla Maria Perri
No information about this author
et al.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 22, 2024
Abstract
Background
In
individuals
diagnosed
with
obstructive
sleep
apnea
syndrome
(OSAS),
variations
in
craniofacial
structure
have
been
inconsistently
documented,
showing
differing
degrees
of
alteration
between
obese
and
nonobese
patients.
addition,
disturbance
has
also
shown
to
induce
disequilibrium
this
population
This
pilot
observational
study
aimed
assess
values
subpopulations
patients
OSAS
their
correlation
association
the
severity
OSAS.
We
assessed
whether
are
characterized
by
an
impaired
equilibrium
relation
associated
Methods
included
all
consecutive
adult
Through
cephalometry,
we
upper
(UPa-UPp)
lower
(LPa-LPp)
pharynx
diameters,
superior
anterior
facial
height
(Sor-ANS),
(ANS-Me),
vertical
dimension
(Sor-Me),
posterior
(S-Go)
craniovertebral
angle
(CVA).
Furthermore,
analyzed
postural
through
a
stabilometric
examination.
Results
Forty
(45%
female
mean
age
56
±
8.2
years)
were
included.
The
subgroup
had
reduced
UPa-UPp
(p
=
0.02).
Cephalometric
measurements
correlated
patients,
whereas
only
Sor-ANS
was
subpopulation.
overall
population,
altered
severe
Although
there
differences
not
or
severity.
Conclusion
Altered
compromised
linked
Therefore,
management
should
be
tailored
weight
but
rehabilitation
enhance
patient
outcomes.
Language: Английский
Mechanisms and treatment of atherosclerosis: focus on macrophages
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 6, 2024
Macrophages
are
the
basic
mediators
and
coordinators
of
various
types
chronic
inflammation
play
a
crucial
role
in
formation
development
atherosclerosis
(AS).
In
complex
microenvironment
atherosclerotic
plaques,
macrophages
different
sources
exposed
to
signal
stimuli
thus
polarized
into
subpopulations.
Various
with
predominantly
M1
M2
phenotypes
also
regulatory
roles
initiation
progression
AS.
Lipid-lowering
drugs,
mainly
statins,
widely
used
clinical
practice,
but
adverse
reactions
obvious
there
is
lack
personalized
treatment.
Emerging
targeted
macrophage
Traditional
Chinese
medicine
(TCM)-related
therapies
can
regulate
cellular
microenvironment,
inhibit
polarization
macrophages,
promote
activation
providing
new
ideas
for
prevention
treatment
Language: Английский
Bidirectional Two-Sample Mendelian Randomization Study of Association between Smoking Initiation and Atrial Fibrillation
Ziyang Wu,
No information about this author
Cheng-Chun Tang,
No information about this author
Dong Wang
No information about this author
et al.
Tobacco Induced Diseases,
Journal Year:
2024,
Volume and Issue:
22(June), P. 1 - 9
Published: June 19, 2024
INTRODUCTION
The
relationship
between
smoking
and
heart
disease
has
been
frequently
reported.Therefore,
we
aimed
to
explore
the
association
initiation
atrial
fibrillation.METHODS
Genetic
data
pertaining
fibrillation
were
obtained
from
genome-wide
studies
(GWAS).Phenotypically
related
single
nucleotide
polymorphisms
(SNPs)
selected
as
instrumental
variables.Inverse-variance
weighted
(IVW),
median,
Mendelian
randomization
(MR),
Egger
regression,
simple
mode,
mode
methods
employed
perform
MR
study.The
was
evaluated
using
odds
ratios
(OR)
95%
confidence
intervals
(CI).Cochran's
Q
test
assess
heterogeneity
among
variables,
utilizing
IVW
MR-Egger
methods.The
Egger-intercept
method
for
horizontal
pleiotropy,
'leave-one-out'
utilized
sensitivity
analysis.RESULTS
results
effect
of
on
(IVW,
OR=1.11;
CI:
1.02-1.20,p=0.013)
supported
an
increased
likelihood
fibrillation.In
total,
85
SNPs
extracted
GWAS
pooled
variables.The
indicated
intercept
close
0
(Egger
intercept=
-0.005,
p=0.371),
suggesting
no
pleiotropy
in
analysis
demonstrated
that
robust
variables
significantly
influenced
results.Reverse
OR=1.00;
0.99-1.02,p=0.684).CONCLUSIONS
Smoking
a
significant
impact
fibrillation.However,
did
not
influence
initiation.This
study
provides
novel
insights
into
genetic
relationships
fibrillation.
Language: Английский
Long-term quality of survival after pediatric low-grade glioma
Child s Nervous System,
Journal Year:
2024,
Volume and Issue:
40(10), P. 3341 - 3355
Published: Oct. 1, 2024
Language: Английский
Assessment of Cephalometric Parameters and Correlation With the Severity of the Obstructive Sleep Apnea Syndrome
Eugenio Garofalo,
No information about this author
Giuseppe Neri,
No information about this author
Lucilla Maria Perri
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 25, 2024
Abstract
Background
In
individuals
diagnosed
with
obstructive
sleep
apnea
syndrome
(OSAS),
variations
in
craniofacial
structure
have
been
inconsistently
documented,
showing
differing
degrees
of
alteration
between
obese
and
nonobese
patients.
addition,
disturbance
has
also
shown
to
induce
disequilibrium
this
population
This
pilot
observational
study
aimed
assess
values
subpopulations
patients
OSAS
their
correlation
association
the
severity
OSAS.
We
assessed
whether
are
characterized
by
an
impaired
equilibrium
relation
associated
Methods
Forty
consecutive
adult
(45%
female)
a
mean
age
56
±
8.18
years
were
included.
Through
cephalometry,
we
upper
(UPa-UPp)
lower
(LPa-LPp)
pharynx
diameters,
superior
anterior
facial
height
(Sor-ANS),
(ANS-Me),
vertical
dimension
(Sor-Me),
posterior
(S-Go)
craniovertebral
angle
(CVA).
Furthermore,
analyzed
postural
through
stabilometric
examination.
Results
Nonobese
had
reduced
UPa-UPp
(p
=
0.02).
Cephalometric
measurements
correlated
patients,
whereas
only
Sor-ANS
was
subpopulation.
overall
population,
altered
severe
Although
there
differences
not
or
severity.
Conclusion
Altered
linked
severity,
which
is
influenced
obesity
but
exclusively;
these
experience
compromised
unrelated
disease
From
translational
medicine
perspective,
findings
underscore
importance
multidisciplinary
approach
management
OSAS,
suggesting
that
interventions
tailored
weight
rehabilitation
could
enhance
patient
outcomes.
identification
specific
alterations
opens
new
avenues
for
development
personalized
diagnostic
tools
therapeutic
devices,
exemplifying
potential
research
bridging
gap
clinical
observations
innovative
treatments.
Language: Английский
Health Education with Videos on Drug Adherence in the Elderly with Hypertension
Komang Ayu Henny Achjar,
No information about this author
Agus Sri Lestari,
No information about this author
Nyoman Ribek
No information about this author
et al.
Journal of Education Research and Evaluation,
Journal Year:
2024,
Volume and Issue:
8(3), P. 576 - 583
Published: Dec. 9, 2024
Adherence
to
medication
in
the
elderly
with
hypertension
is
often
a
challenge,
which
can
increase
risk
of
complications.
The
purpose
this
study
evaluate
effect
health
education
through
video
on
adherence
at
Puskesmas
I
East
Denpasar.
This
uses
quantitative
research
design
pre-experimental
approach.
subjects
were
53
people
hypertension.
Data
collection
was
carried
out
before
and
after
intervention
using
educational
videos,
instruments
form
compliance
questionnaires.
analysis
Wilcoxon
statistical
test.
Before
education,
majority
respondents
showed
low
(52.8%).
After
intervention,
high
rate
increased
significantly
67.9%,
while
decreased
13.2%.
results
test
p-value
=
0.000,
indicating
significant
influence
adherence.
Health
videos
effective
increasing
implications
encourage
application
similar
methods
improve
therapy
various
settings.
Language: Английский