BMC Nephrology,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Dec. 23, 2024
Post-transplant
diabetes
mellitus
(PTDM)
is
a
common
complication
following
renal
transplantation,
and
its
incidence
has
been
gradually
increasing
in
recent
years,
posing
significant
public
health
challenge.
Managing
PTDM
complex,
as
studies
suggest
that
it
involves
changes
the
microbial
flora
across
multiple
organs.
Recent
research
highlights
critical
role
of
gut
metabolism
development
among
post-renal
transplant
patients.
This
paper
reviews
alterations
observed
patients
explores
how
influences
PTDM.
These
findings
may
offer
new
perspectives
on
targeting
metabolites
for
prevention
treatment
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(1), P. e0314029 - e0314029
Published: Jan. 9, 2025
Increasing
evidence
suggests
that
dysbiosis
of
gut
microbiota
exacerbates
chronic
kidney
disease
(CKD)
progression.
Curcumin
(CUR)
has
been
reported
to
alleviate
renal
fibrosis
in
animal
models
CKD.
However,
the
relationship
between
CUR
and
microbiome
CKD
remains
unclear.
This
study
aims
investigate
potential
anti-renal
effects
from
perspective.
A
5/6
nephrectomy
(5/6Nx)
rat
model
was
used
explore
therapeutic
effect
on
fibrosis.
Tight
junction
protein
expression
levels
were
measured
assess
intestinal
barrier
function.
16S
rRNA
sequencing
employed
evaluate
changes
composition,
metabolomics
utilized
detect
alterations
plasma
metabolites.
The
administration
significantly
ameliorated
inhibited
inflammation
5/6Nx
rats.
Additionally,
markedly
improved
tight
proteins
local
colon
inflammation.
also
positively
reconstructed
microbiota,
increasing
abundance
beneficial
bacteria,
such
as
Lachnospiraceae_NK4A136_group
,
Eubacterium_siraeum_group
Muribaculaceae
increased.
Metabolomics
revealed
reduced
uremic
retention
solutes
elevated
Vitamin
D
short-chain
fatty
acids
(SCFAs).
Spearman
correlation
analysis
indicated
genera
enriched
by
correlated
with
SCFA
negatively
injury
biomarkers.
Mechanistically,
we
found
inhibition
LPS/TLR4/NF-κB
TGF-β1/Smads
pathway
CUR-treated
Our
indicates
modulate
this
modulation
may
contribute
anti-fibrosis
CUR.
Clinical Science,
Journal Year:
2024,
Volume and Issue:
138(17), P. 1039 - 1054
Published: Aug. 13, 2024
Maternal
high-fat
diet
intake
has
profound
effects
on
the
long-term
health
of
offspring,
predisposing
them
to
a
higher
susceptibility
obesity
and
metabolic
dysfunction-associated
steatotic
liver
disease.
However,
detailed
mechanisms
underlying
role
maternal
in
hepatic
lipid
accumulation
especially
at
weaning
age,
remain
largely
unclear.
In
this
study,
female
C57BL/6J
mice
were
randomly
assigned
either
or
control
diet,
metabolism
parameters
assessed
male
offspring
weaning.
Gut
microbiota
analysis
targeted
metabolomics
short-chain
fatty
acids
(SCFAs)
these
further
performed.
Both
vivo
vitro
studies
conducted
explore
butyrate
cholesterol
excretion
HepG2
cells.
Our
results
showed
that
feeding
led
dyslipidemia,
exacerbated
livers
We
observed
significant
decreases
abundance
Firmicutes
phylum
Allobaculum
genus,
known
as
producers
SCFAs,
particularly
butyrate,
dams
fed
diet.
Additionally,
markedly
decreased
serum
levels
down-regulated
ATP-binding
cassette
transporters
G5
(ABCG5)
liver,
accompanied
by
phosphorylated
AMP-activated
protein
kinase
(AMPK)
histone
deacetylase
5
(HADC5)
expressions.
Subsequent
revealed
could
induce
ABCG5
activation
alleviate
via
AMPK-pHDAC5
pathway
Moreover,
knockdown
HDAC5
up-regulated
expression
promoted
conclusion,
our
study
provides
novel
insights
into
how
inhibits
down-regulates
through
butyrate-AMPK-pHDAC5
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 27, 2025
Introduction
Chronic
nephrotoxicity
caused
by
CNIs
(CICN)
manifests
clinically
as
chronic
kidney
disease
(CKD).
Astragaloside
IV
(AS-IV)
plays
a
certain
role
in
the
treatment
of
CKD.
This
study
aimed
to
verify
ameliorative
effects
AS-IV
on
CICN
and
further
explore
mechanisms
underlying
modulation
“gut–transcriptome–metabolome
coexpression
network”
within
context
“gut–kidney
axis”
improve
CICN.
Methods
Five
groups
40
mice
were
studied:
normal
group
(N,
olive
oil),
model
(M,
CsA,
30
mg
kg
-−1
d
−1
),
low-dose
(CsA
+
AS-IV,
10
high-dose
20
valsartan
Val,
).
The
gut
microbiota,
renal
transcriptome,
urine
metabolome
separately
detected
construct
gut–transcriptome–metabolome
network.
target
species,
genes,
metabolites
evaluated.
Results
CsA
led
increased
proteinuria
deterioration
function,
accompanied
inflammation
oxidative
stress,
whereas
improved
damage.
inhibited
intestinal
permeability
disrupted
microbiota
structure,
increasing
abundance
Lactobacillus
reuteri
,
Bifidobacterium
animalis
Ignatzschineria
indica
Blautia
glucerasea.
Six
pathways
related
transcription
metabolism,
including
citrate
cycle
ascorbate
aldarate
metabolism
proximal
tubule
bicarbonate
reclamation
glycolysis/gluconeogenesis,
ferroptosis,
drug
metabolism–cytochrome
P450
identified.
Seven
identified
6
pathways,
UDP-D-galacturonic
acid,
2-phenylethanol
glucuronide,
dehydroascorbic
isopentenyl
pyrophosphate,
alpha-D-glucose,
3-carboxy-1-hydroxypropylthiamine
diphosphate
citalopram
aldehyde.
genes
Ugt1a2,
Ugt1a9,
Ugt1a5,
Pck1,
Slc7a11,
also
predicted
NONMMUT144584.1,
MSTRG.30357.1
ENSMUST00000174821.
was
highly
correlated
with
function
AS-IV.
validated.
intestinal-derived
urinary
toxins
tissue
apoptosis,
lipid
accumulation,
collagen
deposition,
mitochondrial
Conclusion
through
six
energy
driven
L.
alderate
tube
are
important
mechanisms.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 30, 2025
Chronic
kidney
disease
has
become
a
public
health
problem
endangering
the
of
all
humans
because
its
high
prevalence,
mortality
and
medical
burden.
The
chronic
micro-inflammatory
state
is
recognized
as
significant
component
CKD,
playing
key
role
in
progression.
Intervening
inflammation
during
course
can
enhance
prognosis.
Recent
studies
have
demonstrated
that
novel
inflammatory
indices,
such
neutrophil-to-lymphocyte
ratio,
platelet-to-lymphocyte
systemic
immune-inflammatory
index
are
closely
associated
with
meanwhile
may
serve
prognostic
monitors
all-cause
death
poor
renal
prognosis
for
disease.
This
article
comprehensively
reports
on
mechanisms
micro-inflammation
relationship
between
indicators
their
impact
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(1), P. e0317960 - e0317960
Published: Jan. 31, 2025
The
urinary
microbiome,
or
urobiome,
is
a
novel
area
of
research
that
has
been
gaining
attention
recently,
as
urine
was
thought
to
be
sterile
for
years.
There
limited
information
about
the
composition
urobiome
in
health
and
disease.
may
affected
by
several
factors
diseases
such
diabetes,
disease
often
leads
kidney
damage.
Thus,
we
need
understand
role
assess
monitor
related
diabetes
over
time.
We
conducted
systematic
review
summarize
knowledge
association
with
mellitus
diabetic
search
electronic
databases
until
November
2024.
Eighteen
studies
were
selected
including
cross-sectional
case-control
studies,
surveys
one
prospective
longitudinal
study.
In
total,
1,571
people
sequenced,
which
662
had
these
36
confirmed
disease;
609
healthy
individuals,
179
prediabetes
at
risk
type
2
121
did
not
have
but
other
comorbidities.
Eight
analysed
data
from
females,
focused
on
male
data,
nine
mixed
female-male
data.
Most
small
sample
size,
used
voided
midstream
urine,
16S
rRNA
sequencing.
This
summarizes
trends
seen
throughout
published
available
first
baseline
its
microbiota,
decreased
richness
α-diversity
microbiota
individuals
compared
controls
evolution
independently
cause.
Metabolic Brain Disease,
Journal Year:
2025,
Volume and Issue:
40(4)
Published: March 24, 2025
NOD-like
receptor
protein
3
(NLRP3)/cysteinyl
aspartate-specific
proteinase
1
(Caspase-1)/gasdermin
D
(GSDMD)-mediated
pyroptosis
is
linked
to
spinal
cord
injury
(SCI)
pathogenesis.
The
levels
of
short-chain
fatty
acids
(SCFAs),
especially
butyric
acid,
are
significantly
altered
after
SCI.
Sodium
butyrate
(NaB)
has
anti-inflammatory
effects
on
SCI;
however,
its
effect
unknown.
aim
this
study
was
determine
the
role
NaB
in
SCI
functional
recovery
and
NLRP3/Caspase-1/GSDMD-mediated
pyroptosis.
model
rats
were
established
using
aneurysm
clips.
After
SCI,
administered
(300
mg/kg)
via
gavage.
SCFAs
faeces
measured
gas
chromatography-mass
spectrometry.
Motor
function
assessed
cylinder
rearing
grooming
tests.
Histopathological
analysis
performed
haematoxylin-eosin
staining,
transmission
electron
microscopy,
terminal
deoxynucleotidyl
transferase
dUTP
nick-end
labelling.
expression
proteins
associated
with
signalling
pathways
analysed
enzyme-linked
immunosorbent
assay,
western
blotting,
immunohistochemistry.
levels,
particularly
decreased
treatment
promoted
forelimb
motor
attenuated
pathological
also
pro-inflammatory
factors
(interleukin-18
interleukin-1β)
downregulated
pyroptosis-related
proteins,
including
NLRP3,
apoptosis-associated
speck-like
protein,
Caspase-1,
GSDMD.
inhibits
neuronal
inflammation,
exerting
protective
therapeutic
suggesting
as
an
effective
treatment.
(including
acid)
reduced
improved
inhibited
inflammation.
Russian Journal of Evidence-Based Gastroenterology,
Journal Year:
2025,
Volume and Issue:
14(1), P. 47 - 47
Published: March 27, 2025
Objective.
To
assess
the
profile
of
short-chain
fatty
acids
(SCFAs)
in
stool
and
content
key
SCFA-producing
bacteria
patients
undergoing
maintenance
hemodialysis.
Material
methods.
This
cross-sectional,
single-center
study
included
30
with
end-stage
renal
disease
(ESRD)
hemodialysis
20
healthy
participants
control
group.
SCFA
levels
samples
were
measured
using
gas-liquid
chromatography.
The
composition
gut
microbiota
was
evaluated
reverse
transcription
polymerase
chain
reaction
(RT-PCR).
Results.
Patients
on
showed
a
significant
reduction
SCFAs
(acetic,
propionic,
butyric
acids)
their
isoacids
compared
to
Additionally,
marked
decrease
(Bifidobacterium
spp.,
Lactobacillus
Faecalibacterium
prausnitzii,
Eubacterium
rectale,
Blautia
Prevotella
Akkermansia
muciniphila)
more
frequently
observed
ESRD
disruption
dialysis
correlated
C-reactive
protein
levels.
Conclusion.
are
characterized
by
abundance
bacteria,
which
may
be
associated
activation
systemic
inflammatory
responses.
