BMC Nephrology,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Dec. 23, 2024
Post-transplant
diabetes
mellitus
(PTDM)
is
a
common
complication
following
renal
transplantation,
and
its
incidence
has
been
gradually
increasing
in
recent
years,
posing
significant
public
health
challenge.
Managing
PTDM
complex,
as
studies
suggest
that
it
involves
changes
the
microbial
flora
across
multiple
organs.
Recent
research
highlights
critical
role
of
gut
metabolism
development
among
post-renal
transplant
patients.
This
paper
reviews
alterations
observed
patients
explores
how
influences
PTDM.
These
findings
may
offer
new
perspectives
on
targeting
metabolites
for
prevention
treatment
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 22, 2024
Abstract
Background
The
urinary
microbiome,
or
urobiome,
is
a
novel
area
of
research
that
has
been
gaining
attention
recently,
as
urine
was
thought
to
be
sterile
for
years.
There
limited
information
about
the
composition
urobiome
in
health
and
disease.
may
affected
by
several
factors
diseases
such
diabetes,
disease
often
leads
kidney
damage.
Thus,
we
need
understand
role
assess
monitor
related
diabetes
over
time.
Methods
We
conducted
systematic
review
summarize
knowledge
association
with
mellitus
diabetic
search
electronic
databases
until
November
2024.
Results
Eighteen
studies
were
selected
including
cross-sectional
case-control
studies,
surveys
one
prospective
longitudinal
study.
In
total,
1,571
people
sequenced,
which
662
had
these
36
confirmed
disease;
609
healthy
individuals,
179
prediabetes
at
risk
type
2
121
did
not
have
but
other
comorbidities.
Eight
analysed
data
from
females,
focused
on
male
data,
nine
mixed
female-male
data.
Most
small
sample
size,
used
voided
midstream
urine,
16S
rRNA
sequencing.
Conclusion
This
summarizes
trends
seen
throughout
published
available
first
baseline
its
microbiota,
decreased
richness
α-diversity
microbiota
individuals
compared
controls
evolution
independently
cause.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 15, 2024
Fecal
microbiota
transplantation
(FMT)
and
probiotics
therapies
represent
key
clinical
options,
yet
their
complex
effects
on
the
host
are
not
fully
understood.
We
evaluated
comprehensive
of
FMT
using
diarrheal
or
normal
feces,
as
well
probiotic
therapies,
multiple
anatomical
sites
in
healthy
cynomolgus
macaques
through
colonoscopy
surgery.
Our
research
revealed
that
led
to
a
partial
microbiome
without
exhibiting
donor’s
fecal
characteristics.
Notably,
increased
insulin
C-peptide
levels
each
animal
according
time
series,
regardless
conditions.
Immunologically,
reduction
neutrophil-to-lymphocyte
ratio
were
exclusively
observed
femoral
veins
group.
In
blood
chemistry
analyses,
reductions
aspartate
aminotransferase,
urea
nitrogen,
creatinine
veins,
while
elevated
alanine
aminotransferase
calcium
detected
portal
veins.
These
changes
Also,
short
chain
fatty
acids
significantly
higher
increase
rather
than
Transcriptome
analysis
liver
tissues
showed
metabolic
pathways
primarily
affected
by
both
therapies.
summary,
therapy
influenced
metabolic,
immunologic
transcriptomic
responses
macaque
models,
these
which
utilize
surgery
colonoscopy,
serve
human-like
preclinical
platform
for
evaluating
long-term
anatomically
specific
gut-targeted
interventions,
need
sacrifice.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 9, 2024
Nephrotic
syndrome
(NS)
represents
a
prevalent
among
various
chronic
kidney
disease
pathologies
and
is
known
for
its
higher
severity
worse
prognosis
compared
with
glomerulonephritis.
Understanding
pathogenesis
identifying
more
effective
treatment
modalities
have
long
been
concern
of
specialists.
With
the
introduction
gut-kidney
axis
concept
progress
in
omics
technologies,
alterations
gut
microbiota
observed
primary
secondary
NS.
This
link
has
extensively
researched
conditions
such
as
diabetic
nephropathy
immunoglobulin
A
(IgA)
nephropathy.
Thus,
dysbiosis
seen
crucial
contributing
factor
NS;
however,
there
lack
comprehensive
reviews
that
elucidate
changes
across
different
NS
describe
mechanistic
role
disease.
Moreover,
serving
an
innate
regulator
microbiota,
traditional
Chinese
medicine
(TCM)
potential
to
exert
profound
impact
on
expression
inflammation-promoting
agents,
decreasing
levels
endotoxins
uremic
toxins.
In
addition,
it
strengthens
stability
intestinal
barrier
while
controlling
metabolic
function
body
through
efficient
modulation
microbiota.
intricate
process
yields
far-reaching
consequences
BMC Nephrology,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Dec. 23, 2024
Post-transplant
diabetes
mellitus
(PTDM)
is
a
common
complication
following
renal
transplantation,
and
its
incidence
has
been
gradually
increasing
in
recent
years,
posing
significant
public
health
challenge.
Managing
PTDM
complex,
as
studies
suggest
that
it
involves
changes
the
microbial
flora
across
multiple
organs.
Recent
research
highlights
critical
role
of
gut
metabolism
development
among
post-renal
transplant
patients.
This
paper
reviews
alterations
observed
patients
explores
how
influences
PTDM.
These
findings
may
offer
new
perspectives
on
targeting
metabolites
for
prevention
treatment
