Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155481 - 155481
Published: July 22, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 814 - 814
Published: Jan. 19, 2025
Bisphenol A (BPA) is a prevalent environmental contaminant found in plastics and known for its endocrine-disrupting properties, posing risks to both human health the environment. Despite widespread presence, impact of BPA on papillary thyroid cancer (PTC) progression, especially under realistic conditions, not well understood. This study examined effects PTC using 3D tumor spheroid model, which better mimicked complex interactions within tissues compared traditional 2D models. Our findings demonstrated that BPA, at environmentally relevant concentrations, could induce significant changes cells, including decrease E-cadherin expression, an increase vimentin reduced thyroglobulin (TG) secretion. These suggest exposure may promote epithelial–mesenchymal transition (EMT), enhance invasiveness, reduce cell differentiation, potentially complicating treatment, by increasing resistance radioiodine therapy. research highlights BPA’s hazardous nature as emphasizes need advanced vitro models, like spheroids, assess posed such chemicals. It provides valuable insights into implications role enhancing our understanding
Language: Английский
Citations
1
MedComm, Journal Year: 2025, Volume and Issue: 6(3)
Published: Feb. 27, 2025
Abstract Liver metastasis is a leading cause of mortality from malignant tumors and significantly impairs the efficacy therapeutic interventions. In recent years, both preclinical clinical research have made significant progress in understanding molecular mechanisms strategies liver metastasis. Metastatic tumor cells different primary sites undergo highly similar biological processes, ultimately achieving ectopic colonization growth liver. this review, we begin by introducing inherent metastatic‐friendly features We then explore panorama conclude three continuous, yet distinct phases based on liver's response to This includes metastatic sensing stage, stress support stage. discuss intricate interactions between various resident recruited cells. addition, emphasize critical role spatial remodeling immune Finally, review advancements challenges faced management Future precise antimetastatic treatments should fully consider individual heterogeneity implement targeted interventions stages
Language: Английский
Citations
0
Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e34032 - e34032
Published: July 1, 2024
Thyroid cancer is the most common malignant tumor of endocrine system, and evidence suggests that post-translational modifications (PTMs) epigenetic alterations play an important role in its development. Recently, there has been increasing linking dysregulation ubiquitinating enzymes deubiquitinases with thyroid cancer. This review aims to summarize our current understanding ubiquitination-modifying cancer, including their regulation oncogenic pathways proteins. The development progression requires further study, which will provide new insights into prevention, treatment novel agents.
Language: Английский
Citations
2
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155481 - 155481
Published: July 22, 2024
Language: Английский
Citations
2