Extracellular Vesicles and Circulating Nucleic Acids, Journal Year: 2024, Volume and Issue: 5(3), P. 471 - 96

Published: July 23, 2024

Cancer cachexia is a complex metabolic syndrome characterized by unintentional loss of skeletal muscle and body fat. This frequently associated with different types cancer negatively affects the prognosis outcome these patients. It involves dynamic interplay between tumor cells adipose tissue, where tumor-derived extracellular vesicles (EVs) play crucial role in mediating intercellular communication. Tumor release EVs containing bioactive molecules such as hormones (adrenomedullin, PTHrP), pro-inflammatory cytokines (IL-6), miRNAs (miR-1304-3p, miR-204-5p, miR-155, miR-425-3p, miR-146b-5p, miR-92a-3p), which can trigger lipolysis induce browning white adipocytes contributing to phenotype. On other hand, adipocyte-derived reprogram metabolism transporting fatty acids enzymes involved acid oxidation, resulting growth progression. These also carry leptin key (miR-155-5p, miR-10a-3p, miR-30a-3p, miR-32a/b, miR-21), thereby supporting cell proliferation, metastasis formation, therapy resistance. Understanding intricate network underlying EV-mediated communication provide critical insights into mechanisms driving cachexia. review consolidates current knowledge on crosstalk tissue mediated offers valuable for future research. addresses controversial topics field possible therapeutic approaches manage ultimately improve patient outcomes quality life.

Language: Английский