Checkpoint kinase 1 as a promising target in colorectal cancer management DOI
Wenxue Ma, Natalia Baran

World Journal of Clinical Oncology, Journal Year: 2025, Volume and Issue: 16(4)

Published: March 26, 2025

This editorial provides insights into the pivotal role of checkpoint kinase 1 (CHEK1) as both a biomarker and therapeutic target in colorectal cancer (CRC), based on findings from recent study by Pang et al . Using single-cell RNA sequencing immunohistochemistry, demonstrates significant CHEK1 overexpression CRC tissues identifies nitidine chloride potent inhibitor that disrupts DNA damage repair pathways. These underscore potential inhibition highlight need for further research to address gaps treatment.

Language: Английский

RPRD1B’s direct interaction with phosphorylated RNA Polymerase II regulates polyadenylation of cell cycle genes and drives cancer progression DOI Creative Commons
Rosamaria Y. Moreno, Svetlana Panina, Yan Zhang

et al.

RSC Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

RNA polymerase II (Pol II) regulates eukaryotic gene expression through dynamic phosphorylation of its C-terminal domain (CTD).

Language: Английский

Citations

0
Checkpoint kinase 1 as a promising target in colorectal cancer management DOI
Wenxue Ma, Natalia Baran

World Journal of Clinical Oncology, Journal Year: 2025, Volume and Issue: 16(4)

Published: March 26, 2025

This editorial provides insights into the pivotal role of checkpoint kinase 1 (CHEK1) as both a biomarker and therapeutic target in colorectal cancer (CRC), based on findings from recent study by Pang et al . Using single-cell RNA sequencing immunohistochemistry, demonstrates significant CHEK1 overexpression CRC tissues identifies nitidine chloride potent inhibitor that disrupts DNA damage repair pathways. These underscore potential inhibition highlight need for further research to address gaps treatment.

Language: Английский

Citations

0