Biocomposite Polyvinyl Alcohol/Ferritin Hydrogels with Enhanced Stretchability and Conductivity for Flexible Strain Sensors

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 59 - 59

Published: Jan. 11, 2025

Protein-based hydrogels with stretchability and conductivity have potential applications in wearable electronic devices. However, the development of protein-based biocomposite is still limited. In this work, we used natural ferritin to develop a PVA/ferritin hydrogel by repetitive freeze–thaw method. hydrogel, ferritin, as nano spring, forms hydrogen bond PVA networks, which reduces crystallinity significantly improves hydrogel. The fracture strain 203%, stress 112.2 kPa. toughness enhanced 147.03 kJ/m3, more than 3 times that (39.17 kJ/m3). addition, free residues iron ions endow ionic (0.15 S/m). sensor constructed from shows good sensitivity (gauge factor = 1.7 at 150% strain), accurate real-time resistance response, long cyclic working stability when for joint motion monitoring. results indicate prepared facile method has flexible sensors. This work develops new preparation

Language: Английский

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Chitosan and hyaluronic acid in breast cancer treatment: Anticancer efficacy and nanoparticle and hydrogel development

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140144 - 140144

Published: Jan. 21, 2025

Language: Английский

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Chitosan-based hydrogels in cancer therapy: Drug and gene delivery, stimuli-responsive carriers, phototherapy and immunotherapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137047 - 137047

Published: Nov. 1, 2024

Language: Английский

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Polyacrylic Acid-Reinforced gelatin hydrogels with enhanced mechanical properties, temperature-responsiveness and antimicrobial activity for smart encryption and salmon freshness monitoring

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 725 - 741

Published: Nov. 9, 2024

Language: Английский

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Hydrogel-based bimodal sensors for high-sensitivity independent detection of temperature and strain

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 832 - 844

Published: Nov. 13, 2024

Language: Английский

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Polysaccharide-based ionic hydrogels: Comprehensive evaluation of conductivity, mechanical properties, and anti-freezing and anti-drying properties

Polymers from Renewable Resources, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

The use of conductive hydrogels in flexible electronics has gained significant attention recent years. However, the performance traditional is often hindered by dehydration at elevated temperatures and structural rigidity when frozen low temperatures. In this study, we developed a double-network hydrogel consisting ionically crosslinked pectin covalently polyacrylamide (PAAm) networks. Scanning Electron Microscopy (SEM) analysis revealed highly interconnected porous microstructure, which contributes to enhanced mechanical strength flexibility hydrogel. Through solvent exchange process, PAAm-pectin was transformed into an organo-gel immersing it binary system ethylene glycol water. incorporation significantly improved hydrogel’s temperature tolerance, imparting superior anti-freezing anti-drying properties. resulting organogel exhibited remarkable transparency, excellent flexibility, sustained ionic conductivity even as −40°C. These attributes highlight promising candidate for next-generation electronic devices, where stability under extreme conditions essential.

Language: Английский

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Nanotecnologia no tratamento personalizado do Câncer: inovação que redefine a precisão e eficiência na terapia oncológica

Cuadernos de Educación y Desarrollo, Journal Year: 2025, Volume and Issue: 17(2), P. e7578 - e7578

Published: Feb. 18, 2025

A nanotecnologia tem se destacado no tratamento do câncer, oferecendo vantagens como a melhoria da biodisponibilidade dos fármacos, redução de efeitos colaterais e tratamentos mais personalizados. O uso nanopartículas permite uma entrega precisa medicamentos, atingindo diretamente as células tumorais minimizando o impacto nas saudáveis. Essa abordagem aumenta eficácia das terapias, principalmente cânceres resistentes às terapias convencionais. liberação controlada fármacos por otimiza tratamento, possibilitando doses baixas ação terapêutica contínua. funcionalização nanopartículas, com ligantes específicos, direcionamento preciso para tumorais, reduzindo toxicidade convencionais, quimioterapia. Além disso, combinação diferentes modalidades terapêuticas, quimioterapia, imunoterapia radioterapia, em única plataforma mostrado ser eficaz na respostas terapêuticas combate à resistência tumoral. Apesar avanços, aplicação clínica enfrenta desafios, produção larga escala, garantia segurança estabilidade longo prazo. escalabilidade fabricação, qualidade biocompatibilidade ainda precisam aprimoradas que essas tornem acessíveis seguras. pesquisa contínua é essencial superar esses obstáculos permitir revolucione proporcionando eficazes menos colaterais.

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Nanotechnology in the perioperative treatment of head and neck cancer: application and outlook

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 27, 2025

Head and neck cancer (HNC) critically affects patient survival quality of life, highlighting the need for optimized perioperative interventions. While conventional therapies face limitations in specificity toxicity, nanotechnology has emerged as a revolutionary approach. Preoperative application tumor-targeting nanoprobes enables molecular-level lesion identification via biomarker-specific conjugation spatially resolved fluorescence quantification. Intraoperatively, fluorescent nanomaterials enhance surgical precision through selective tumor accumulation, delineating malignant margins real time. Postoperatively, engineered nanocarriers improve therapeutic outcomes by delivering drugs with spatial control, minimizing off-target effects, enabling multimodal synergies. These nanotechnology-driven strategies collectively address critical challenges HNC management, including diagnostic sensitivity, intraoperative visualization, postoperative recurrence. Their inherent advantages—precision targeting, reduced systemic multifunctional integration—establish them cornerstone tools modern oncology. Future advancements nanomaterial design biocompatibility are poised to further refine efficacy, rates, patient-centered outcomes.

Language: Английский

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Localized Cancer Treatment Using Thiol–Ene Hydrogels for Dual Drug Delivery

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% 33%). Rheological analysis confirmed enhanced viscoelasticity increasing (99Gel-33 > 99Gel-16 23Gel-33 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) carvacrol (CRV), exhibiting tumor-responsive degradation tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% PBS), while CRV showed an initial burst followed sustained promoted mesenchymal stem cell proliferation effectively inhibited triple-negative breast cells. injectable, offers promising platform minimally invasive, personalized therapy.

Language: Английский

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Advances in hydrogel research: a 25-year bibliometric overview

Journal of Materials Science Materials in Medicine, Journal Year: 2025, Volume and Issue: 36(1)

Published: May 14, 2025

Language: Английский

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