Alcohol exposure alters the diversity and composition of oral microbiome

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 7, 2025

Alcohol exposure has been shown to have complex, and sometimes paradoxical, associations with various serious diseases. Currently, there is no knowledge about the effects of alcohol on dynamics oral microbial communities. The study aims investigate chronic consumption diversity composition rat microbiota using 16S rRNA gene amplicon sequencing. In our study, were 2 groups, including a control group (C group) an (A group), 10 rats in every group. For ten weeks, A treated intragastrically day, whereas C got water. After serum levels alanine aminotransferase (ALT) aspartate (AST) measured. Oral swabs taken from both total DNA was extracted for high-throughput sequencing gene. According results obtained significant differences observed relative abundances Alpha measures statistically significantly higher (P < 0.05) compared At genus level, altered abundance several microbes, increased unidentified_Chloroplast, Acinetobacter, Vibrio, Romboutsia, Pseudoalteromonas, Aeromonas, Ralstonia, Turicibacter, Shewanella, Bacteroides. Conversely, Haemophilus Streptococcus less abundant associated microbiome. These findings contribute understanding potential role bacteria alcohol-related systemic diseases, providing foundational work future prevention intervention studies.

Language: Английский

The Burden of Esophageal Cancer in Five East Asian Countries From 1990 to 2021 and Its Prediction Until 2036: An Analysis of the Global Burden of Diseases Study 2021

Thoracic Cancer, Journal Year: 2025, Volume and Issue: 16(8)

Published: April 1, 2025

In 2022, esophageal cancer (EC) was the eleventh most frequently diagnosed and seventh leading cause of cancer-related deaths worldwide. Nonetheless, prevalence burden EC in Asian countries have been little studied. This study investigated prevalence, incidence, five East from 1990 to 2021. We retrieved data Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021 on mortality, years lived with disability (YLDs), life lost (YLLs), disability-adjusted (DALYs) associated The epidemiological characteristics were analyzed by joinpoint regression, age-period-cohort analysis, decomposition analysis. until 2036 estimated using autoregressive integrated moving average Bayesian models. Among these countries, China had highest mortality rates, YLLs, YLDs, DALYs Mongolia exhibited age-standardized incidence rate, YLDs YLLs rate 2036. age group ≥ 55 years. rates influenced aging higher than global average. high over past three decades, particularly among older adults. is a significant public health problem because large population base demographics.

Language: Английский